Geological and stratigraphic elements of the Proterozoic units of the Serro region, Mato Grosso Quadrangle, show the absence of the faciological transition between the Espinhaco Group and the Minas Supergroup. Occurs in this region is a lithostratigraphical sequence of four distinct units: the Crystalline Basement; the Volcano-Sedimentary Sequence of Serro; the Minas Supergroup. The ore potential of the region includes: quartz veins, within the Galho do Miguel Formation; diamond, within the Sopa conglomerates; gold, in alluvial deposits and remobilized in quartz veins of the Sopa-Brumadinho Formation; bauxite, in the metabasics; uranium in the metaconglomerates of Moeda Formation; iron, in Caue Formation; chromium, gold and base metals in the Volcano-Sedimentary Sequence of Serro. Emphasis is given to the characterization of the Volcano-Sedimentary Sequence of Serro and its mineralization that is characterized as a stratiform massif with important volcano-sedimentary contribution, possible, a greenstone belt, with high gold-bearing potential. (author).