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Clinical experience of photon counting breast tomosynthesis: comparison with traditional mammography

Abstract

Background: In two-dimensional mammography, a well-known problem is over- and underlying tissue which can either obstruct a lesion or create a false-positive result. Tomosynthesis, with an ability to layer the tissue in the image, has the potential to resolve these issues. Purpose: To compare the diagnostic quality, sensitivity and specificity of a single tomosynthesis mammography image and a traditional two-view set of two-dimensional mammograms and to assess the comfort of the two techniques. Material and Methods: One hundred and forty-four women, mainly chosen because of suspicious features on standard mammograms (76 malignant), had a single tomosynthesis image taken of one breast using a novel photon counting system. On average, the dose of the tomosynthesis images was 0.63 times that of the two-view images and the compression force during the procedure was halved. The resulting images were viewed by two radiologists and assessed both individually and comparing the two techniques. Results: In 56% of the cases the radiologists rated the diagnostic quality of the lesion details higher in the tomosynthesis images than in the conventional images (and in 91% equal or higher), which means there is a statistically significant preference for the tomosynthesis technique. This included the calcifications which were rated  More>>
Authors:
Svane, Gunilla; Azavedo, Edward; [1]  Lindman, Karin; Urech, Mattias; Nilsson, Jonas; Weber, Niclas; Lindqvist, Lars; Ullberg, Christer [2] 
  1. Dept. of Radiology, Karolinska Univ. Hospital and Dept. of Molecular Medicine and Surgery, Karolinska Institute Stockholm (Sweden)
  2. XCounter AB, Danderyd (Sweden)
Publication Date:
Feb 15, 2011
Product Type:
Journal Article
Resource Relation:
Journal Name: Acta Radiologica (online); Journal Volume: 52; Journal Issue: 2; Other Information: 27 refs., 7 figs., 2 tabs.; 10.1258/AR.2010.100262
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; TOMOGRAPHY; PHOTONS; MAMMARY GLANDS; CARCINOGEN SCREENING; RADIATION DOSES
OSTI ID:
1010786
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1600-0455; TRN: SE1108056
Availability:
Available from DOI: http://dx.doi.org/10.1258/ar.2010.100262
Submitting Site:
SWDN
Size:
page(s) 134-142
Announcement Date:
Apr 11, 2011

Citation Formats

Svane, Gunilla, Azavedo, Edward, Lindman, Karin, Urech, Mattias, Nilsson, Jonas, Weber, Niclas, Lindqvist, Lars, and Ullberg, Christer. Clinical experience of photon counting breast tomosynthesis: comparison with traditional mammography. Sweden: N. p., 2011. Web. doi:10.1258/AR.2010.100262.
Svane, Gunilla, Azavedo, Edward, Lindman, Karin, Urech, Mattias, Nilsson, Jonas, Weber, Niclas, Lindqvist, Lars, & Ullberg, Christer. Clinical experience of photon counting breast tomosynthesis: comparison with traditional mammography. Sweden. doi:10.1258/AR.2010.100262.
Svane, Gunilla, Azavedo, Edward, Lindman, Karin, Urech, Mattias, Nilsson, Jonas, Weber, Niclas, Lindqvist, Lars, and Ullberg, Christer. 2011. "Clinical experience of photon counting breast tomosynthesis: comparison with traditional mammography." Sweden. doi:10.1258/AR.2010.100262. https://www.osti.gov/servlets/purl/10.1258/AR.2010.100262.
@misc{etde_1010786,
title = {Clinical experience of photon counting breast tomosynthesis: comparison with traditional mammography}
author = {Svane, Gunilla, Azavedo, Edward, Lindman, Karin, Urech, Mattias, Nilsson, Jonas, Weber, Niclas, Lindqvist, Lars, and Ullberg, Christer}
abstractNote = {Background: In two-dimensional mammography, a well-known problem is over- and underlying tissue which can either obstruct a lesion or create a false-positive result. Tomosynthesis, with an ability to layer the tissue in the image, has the potential to resolve these issues. Purpose: To compare the diagnostic quality, sensitivity and specificity of a single tomosynthesis mammography image and a traditional two-view set of two-dimensional mammograms and to assess the comfort of the two techniques. Material and Methods: One hundred and forty-four women, mainly chosen because of suspicious features on standard mammograms (76 malignant), had a single tomosynthesis image taken of one breast using a novel photon counting system. On average, the dose of the tomosynthesis images was 0.63 times that of the two-view images and the compression force during the procedure was halved. The resulting images were viewed by two radiologists and assessed both individually and comparing the two techniques. Results: In 56% of the cases the radiologists rated the diagnostic quality of the lesion details higher in the tomosynthesis images than in the conventional images (and in 91% equal or higher), which means there is a statistically significant preference for the tomosynthesis technique. This included the calcifications which were rated as having better quality in 41% of the cases. While sensitivity was slightly higher for traditional mammography the specificity was higher for tomosynthesis. However, neither of these two differences was large enough to be statistically significant. Conclusion: The overall accuracy of the two techniques was virtually equal despite the radiologist's very limited experience with tomosynthesis images and vast experience with two-dimensional mammography. As the diagnostic quality of the lesion details in the tomosynthesis images was valued considerably higher this factor should improve with experience. The patients also favored the tomosynthesis examination, rating the comfort of the procedure as much higher than regular mammography which might affect screening attendance}
doi = {10.1258/AR.2010.100262}
journal = {Acta Radiologica (online)}
issue = {2}
volume = {52}
place = {Sweden}
year = {2011}
month = {Feb}
}