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Whole-body diffusion-weighted imaging compared with FDG-PET/CT in staging of lymphoma patients

Abstract

Background: Diffusion-weighted imaging (DWI) has become increasingly valuable in lymph node imaging, yet the clinical utility of this technique in the staging of lymphoma has not been established. Purpose: To compare whole-body DWI with FDG-PET/CT in the staging of lymphoma patients. Material and Methods: Thirty-one patients, eight with Hodgkin lymphoma (HL) and 23 with non-Hodgkin's lymphoma (18 aggressive and five indolent) underwent both whole-body DWI, whole-body MRI (T1W and T2W-STIR) and FDG-PET/CT. Lesions on whole-body DWI were only considered positive if they correlated with lesions on T1W and T2W-STIR images. The staging given by each technique was compared, according to the Ann Arbor staging system. Differences in staging were solved using biopsy results, and clinical and CT follow-ups as standard of reference. Results: The staging was the same for DWI and FDG-PET/CT in 28 (90.3%) patients and different in three (9.7%). Of the 28 patients with the same staging, 11 had stage IV in both techniques and 17 had stages 0-III. No HL or aggressive non-Hodgkin's lymphoma patients had different staging. Three indolent small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) lymphoma had higher staging with DWI when compared with FDG-PET/CT. One small subcutaneous breast lymphoma was not seen but all other  More>>
Authors:
Abdulqadhr, Goran; Johansson, Lars; Ahlstroem, Haakan; [1]  Molin, Daniel; Hagberg, Hans; [2]  Aastroem, Gunnar; [1]  Dept. of Oncology, Uppsala Univ. Hospital, Uppsala (Sweden)); Suurkuela, Madis [3] 
  1. Dept. of Radiology, Uppsala Univ. Hospital, Uppsala (Sweden)
  2. Dept. of Oncology, Uppsala Univ. Hospital, Uppsala (Sweden)
  3. Dept. of Nuclear Medicine, Uppsala Univ. Hospital, Uppsala (Sweden)
Publication Date:
Feb 15, 2011
Product Type:
Journal Article
Resource Relation:
Journal Name: Acta Radiologica (online); Journal Volume: 52; Journal Issue: 2; Other Information: 32 refs., 3 figs., 4 tabs.; 10.1258/AR.2010.100246
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; POSITRON COMPUTED TOMOGRAPHY; LYMPHOMAS; EVALUATION; FLUORODEOXYGLUCOSE
OSTI ID:
1010781
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 1600-0455; TRN: SE1108051
Availability:
Available from DOI: http://dx.doi.org/10.1258/ar.2010.100246
Submitting Site:
SWDN
Size:
page(s) 173-180
Announcement Date:
Apr 11, 2011

Citation Formats

Abdulqadhr, Goran, Johansson, Lars, Ahlstroem, Haakan, Molin, Daniel, Hagberg, Hans, Aastroem, Gunnar, Dept. of Oncology, Uppsala Univ. Hospital, Uppsala (Sweden)), and Suurkuela, Madis. Whole-body diffusion-weighted imaging compared with FDG-PET/CT in staging of lymphoma patients. Sweden: N. p., 2011. Web. doi:10.1258/AR.2010.100246.
Abdulqadhr, Goran, Johansson, Lars, Ahlstroem, Haakan, Molin, Daniel, Hagberg, Hans, Aastroem, Gunnar, Dept. of Oncology, Uppsala Univ. Hospital, Uppsala (Sweden)), & Suurkuela, Madis. Whole-body diffusion-weighted imaging compared with FDG-PET/CT in staging of lymphoma patients. Sweden. doi:10.1258/AR.2010.100246.
Abdulqadhr, Goran, Johansson, Lars, Ahlstroem, Haakan, Molin, Daniel, Hagberg, Hans, Aastroem, Gunnar, Dept. of Oncology, Uppsala Univ. Hospital, Uppsala (Sweden)), and Suurkuela, Madis. 2011. "Whole-body diffusion-weighted imaging compared with FDG-PET/CT in staging of lymphoma patients." Sweden. doi:10.1258/AR.2010.100246. https://www.osti.gov/servlets/purl/10.1258/AR.2010.100246.
@misc{etde_1010781,
title = {Whole-body diffusion-weighted imaging compared with FDG-PET/CT in staging of lymphoma patients}
author = {Abdulqadhr, Goran, Johansson, Lars, Ahlstroem, Haakan, Molin, Daniel, Hagberg, Hans, Aastroem, Gunnar, Dept. of Oncology, Uppsala Univ. Hospital, Uppsala (Sweden)), and Suurkuela, Madis}
abstractNote = {Background: Diffusion-weighted imaging (DWI) has become increasingly valuable in lymph node imaging, yet the clinical utility of this technique in the staging of lymphoma has not been established. Purpose: To compare whole-body DWI with FDG-PET/CT in the staging of lymphoma patients. Material and Methods: Thirty-one patients, eight with Hodgkin lymphoma (HL) and 23 with non-Hodgkin's lymphoma (18 aggressive and five indolent) underwent both whole-body DWI, whole-body MRI (T1W and T2W-STIR) and FDG-PET/CT. Lesions on whole-body DWI were only considered positive if they correlated with lesions on T1W and T2W-STIR images. The staging given by each technique was compared, according to the Ann Arbor staging system. Differences in staging were solved using biopsy results, and clinical and CT follow-ups as standard of reference. Results: The staging was the same for DWI and FDG-PET/CT in 28 (90.3%) patients and different in three (9.7%). Of the 28 patients with the same staging, 11 had stage IV in both techniques and 17 had stages 0-III. No HL or aggressive non-Hodgkin's lymphoma patients had different staging. Three indolent small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) lymphoma had higher staging with DWI when compared with FDG-PET/CT. One small subcutaneous breast lymphoma was not seen but all other extranodal sites were detected by both techniques. Conclusion: Whole-body DWI is a promising technique for staging of both (aggressive and indolent) non- Hodgkin's lymphoma and HL}
doi = {10.1258/AR.2010.100246}
journal = {Acta Radiologica (online)}
issue = {2}
volume = {52}
place = {Sweden}
year = {2011}
month = {Feb}
}