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Modeling the systemic retention of beryllium in rat. Extrapolation to human; Modelizacion de la retencion sistemica del Berilio en la rata. Extrapolacion al hombre

Technical Report:

Abstract

In this work, we analyzed different approaches, assayed in order to numerically describe the systemic behaviour of Beryllium. The experimental results used in this work, were previously obtained by Furchner et al. (1973), using Sprague-Dawley rats, and other animal species. Furchner`s work includes the obtained model for whole body retention in rats but not for each target organ. In this work we present the results obtained by modeling the kinetic behaviour of Beryllium in several target organs. The results of this kind of models were used in order to establish correlations among the estimated kinetic constants. The parameters of the model were extrapolated to humans and, finally, compared with other previously published.
Publication Date:
Dec 31, 1994
Product Type:
Technical Report
Report Number:
CIEMAT-747
Reference Number:
SCA: 560160; PA: SPN-94:0B0826; EDB-95:017400; SN: 95001297676
Resource Relation:
Other Information: PBD: [1994]
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BERYLLIUM; MICE; RADIONUCLIDE KINETICS; CONCENTRATION RATIO; BIOLOGICAL MODELS; 560160; RADIONUCLIDE EFFECTS, KINETICS, AND TOXICOLOGY
OSTI ID:
10104735
Research Organizations:
Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas (CIEMAT), Madrid (Spain)
Country of Origin:
Spain
Language:
Spanish
Other Identifying Numbers:
Other: ON: DE95722441; TRN: ES94B0826
Availability:
OSTI; NTIS; INIS
Submitting Site:
INIS
Size:
36 p.
Announcement Date:
Jun 30, 2005

Technical Report:

Citation Formats

Montero Prieto, M, and Vidania Muoz, R de. Modeling the systemic retention of beryllium in rat. Extrapolation to human; Modelizacion de la retencion sistemica del Berilio en la rata. Extrapolacion al hombre. Spain: N. p., 1994. Web.
Montero Prieto, M, & Vidania Muoz, R de. Modeling the systemic retention of beryllium in rat. Extrapolation to human; Modelizacion de la retencion sistemica del Berilio en la rata. Extrapolacion al hombre. Spain.
Montero Prieto, M, and Vidania Muoz, R de. 1994. "Modeling the systemic retention of beryllium in rat. Extrapolation to human; Modelizacion de la retencion sistemica del Berilio en la rata. Extrapolacion al hombre." Spain.
@misc{etde_10104735,
title = {Modeling the systemic retention of beryllium in rat. Extrapolation to human; Modelizacion de la retencion sistemica del Berilio en la rata. Extrapolacion al hombre}
author = {Montero Prieto, M, and Vidania Muoz, R de}
abstractNote = {In this work, we analyzed different approaches, assayed in order to numerically describe the systemic behaviour of Beryllium. The experimental results used in this work, were previously obtained by Furchner et al. (1973), using Sprague-Dawley rats, and other animal species. Furchner`s work includes the obtained model for whole body retention in rats but not for each target organ. In this work we present the results obtained by modeling the kinetic behaviour of Beryllium in several target organs. The results of this kind of models were used in order to establish correlations among the estimated kinetic constants. The parameters of the model were extrapolated to humans and, finally, compared with other previously published.}
place = {Spain}
year = {1994}
month = {Dec}
}