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Studies of labelling of melphalan with technetium-99m; Badania nad znakowaniem melfalanu technetem-99m

Abstract

Melphalan is an alkylating agent widely used in the treatment of neoplastic diseases. However, being an {alpha}-amino acid it cannot be labeled with Tc-99m by the use of SnCl{sub 2} for pertechnetate reduction. The N-carboxy methyl - derivative of melphalan was obtained and its complexing by technetium-99m was examined. A procedure for labelling of melphalan derivative with Tc-99m has been developed. (author). 18 refs, 8 figs, 8 tabs.
Authors:
Nowak, M [1] 
  1. Institute of Atomic Energy, Otwock-Swierk (Poland)
Publication Date:
Dec 31, 1991
Product Type:
Technical Report
Report Number:
IAE-2110/OBRI/B/B
Reference Number:
SCA: 400703; PA: AIX-26:004864; EDB-95:009162; SN: 95001298739
Resource Relation:
Other Information: PBD: 1991
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; AMINO ACIDS; LABELLING; TECHNETIUM 99; LABELLED COMPOUNDS; RADIOPHARMACEUTICALS; 400703; RADIOISOTOPE PRODUCTION
OSTI ID:
10102706
Research Organizations:
Institute of Atomic Energy, Otwock-Swierk (Poland)
Country of Origin:
Poland
Language:
Polish
Other Identifying Numbers:
Other: ON: DE95609603; TRN: PL9400589004864
Availability:
OSTI; NTIS; INIS
Submitting Site:
PLN
Size:
24 p.
Announcement Date:
Jun 30, 2005

Citation Formats

Nowak, M. Studies of labelling of melphalan with technetium-99m; Badania nad znakowaniem melfalanu technetem-99m. Poland: N. p., 1991. Web.
Nowak, M. Studies of labelling of melphalan with technetium-99m; Badania nad znakowaniem melfalanu technetem-99m. Poland.
Nowak, M. 1991. "Studies of labelling of melphalan with technetium-99m; Badania nad znakowaniem melfalanu technetem-99m." Poland.
@misc{etde_10102706,
title = {Studies of labelling of melphalan with technetium-99m; Badania nad znakowaniem melfalanu technetem-99m}
author = {Nowak, M}
abstractNote = {Melphalan is an alkylating agent widely used in the treatment of neoplastic diseases. However, being an {alpha}-amino acid it cannot be labeled with Tc-99m by the use of SnCl{sub 2} for pertechnetate reduction. The N-carboxy methyl - derivative of melphalan was obtained and its complexing by technetium-99m was examined. A procedure for labelling of melphalan derivative with Tc-99m has been developed. (author). 18 refs, 8 figs, 8 tabs.}
place = {Poland}
year = {1991}
month = {Dec}
}