Abstract
2-Methoxyisobutylisonitrile (MIBI) is a key starting material in the preparation of technetium-99m hexakis (2-methoxyisobutylisonitrile). This cationic complex has been reported to be clinically useful as myocardial perfusion agent. In this work, we designed an improved synthetic method to prepare 2-methoxyisobutylisonitrile in a two step synthesis with an overall yield of 52.9 % , on the basis of 2-methoxyisobutylamine is a primary amine which, when is heated with a mixture of chloroform and alcoholic potash, produces an isonitrile. Its spectroscopic properties as well as the preparation of its copper and technetium-99m complexes are also presented. (Author).
Citation Formats
Ramirez G, L.
Synthesis of Cu[MIBI]{sub 4}Cl to prepare {sup 99m} Tc [MIBI]{sup 6+} as a myocardial perfusion agent; Sintesis del complejo Cu [MIBI]{sub 4} Cl como precursor del radiofarmaco {sup 99m} Tc [MIBI]{sup 6+} para evaluacion cardiaca..
Mexico: N. p.,
1994.
Web.
Ramirez G, L.
Synthesis of Cu[MIBI]{sub 4}Cl to prepare {sup 99m} Tc [MIBI]{sup 6+} as a myocardial perfusion agent; Sintesis del complejo Cu [MIBI]{sub 4} Cl como precursor del radiofarmaco {sup 99m} Tc [MIBI]{sup 6+} para evaluacion cardiaca..
Mexico.
Ramirez G, L.
1994.
"Synthesis of Cu[MIBI]{sub 4}Cl to prepare {sup 99m} Tc [MIBI]{sup 6+} as a myocardial perfusion agent; Sintesis del complejo Cu [MIBI]{sub 4} Cl como precursor del radiofarmaco {sup 99m} Tc [MIBI]{sup 6+} para evaluacion cardiaca."
Mexico.
@misc{etde_10102686,
title = {Synthesis of Cu[MIBI]{sub 4}Cl to prepare {sup 99m} Tc [MIBI]{sup 6+} as a myocardial perfusion agent; Sintesis del complejo Cu [MIBI]{sub 4} Cl como precursor del radiofarmaco {sup 99m} Tc [MIBI]{sup 6+} para evaluacion cardiaca.}
author = {Ramirez G, L}
abstractNote = {2-Methoxyisobutylisonitrile (MIBI) is a key starting material in the preparation of technetium-99m hexakis (2-methoxyisobutylisonitrile). This cationic complex has been reported to be clinically useful as myocardial perfusion agent. In this work, we designed an improved synthetic method to prepare 2-methoxyisobutylisonitrile in a two step synthesis with an overall yield of 52.9 % , on the basis of 2-methoxyisobutylamine is a primary amine which, when is heated with a mixture of chloroform and alcoholic potash, produces an isonitrile. Its spectroscopic properties as well as the preparation of its copper and technetium-99m complexes are also presented. (Author).}
place = {Mexico}
year = {1994}
month = {Dec}
}
title = {Synthesis of Cu[MIBI]{sub 4}Cl to prepare {sup 99m} Tc [MIBI]{sup 6+} as a myocardial perfusion agent; Sintesis del complejo Cu [MIBI]{sub 4} Cl como precursor del radiofarmaco {sup 99m} Tc [MIBI]{sup 6+} para evaluacion cardiaca.}
author = {Ramirez G, L}
abstractNote = {2-Methoxyisobutylisonitrile (MIBI) is a key starting material in the preparation of technetium-99m hexakis (2-methoxyisobutylisonitrile). This cationic complex has been reported to be clinically useful as myocardial perfusion agent. In this work, we designed an improved synthetic method to prepare 2-methoxyisobutylisonitrile in a two step synthesis with an overall yield of 52.9 % , on the basis of 2-methoxyisobutylamine is a primary amine which, when is heated with a mixture of chloroform and alcoholic potash, produces an isonitrile. Its spectroscopic properties as well as the preparation of its copper and technetium-99m complexes are also presented. (Author).}
place = {Mexico}
year = {1994}
month = {Dec}
}