"TITLE","AUTHORS","SUBJECT","SUBJECT_RELATED","DESCRIPTION","PUBLISHER","AVAILABILITY","RESEARCH_ORG","SPONSORING_ORG","PUBLICATION_COUNTRY","PUBLICATION_DATE","CONTRIBUTING_ORGS","LANGUAGE","RESOURCE_TYPE","TYPE_QUALIFIER","JOURNAL_ISSUE","JOURNAL_VOLUME","RELATION","COVERAGE","FORMAT","IDENTIFIER","REPORT_NUMBER","DOE_CONTRACT_NUMBER","OTHER_IDENTIFIER","DOI","RIGHTS","ENTRY_DATE","OSTI_IDENTIFIER","PURL_URL" "Calcium-antagonists and islet function. V. Effect of R33711","Malaisse, W J; Sener, A; Devis, G; Somers, G [Brussels Univ. (Belgium). Lab. of Experimental Medicine]","59 BASIC BIOLOGICAL SCIENCES; CALCIUM 45; METABOLISM; CHEMICAL REACTIONS; DIAGNOSIS; INSULIN; PANCREAS; RATS; THEOPHYLLINE; THERAPY; TRACER TECHNIQUES; UREA; ALKALINE EARTH ISOTOPES; AMIDES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CALCIUM ISOTOPES; CARBONIC ACID DERIVATIVES; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DIURETICS; DRUGS; ENDOCRINE GLANDS; EVEN-ODD NUCLEI; GLANDS; HETEROCYCLIC COMPOUNDS; HORMONES; INTERMEDIATE MASS NUCLEI; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; PEPTIDE HORMONES; PURINES; RADIOISOTOPES; RODENTS; VERTEBRATES; XANTHINES; 550501* - Metabolism- Tracer Techniques","","R33711, a new drug with presumed potent calcium-antagonistic property, was found to suppress the insulinotropic action of glucose und gliclazide but not that of theophylline. A 0.2 ..mu..M concentration of R33711 was sufficient to abolish glucose-induced insulin release. At this concentration, R33711 inhibited the net uptake of /sup 45/Ca/sup 2 +/ by isolated islets, whether in the absence or presence of either glucose or sulfonylurea. In the isolated islets, R33711 failed to affect the glucose-stimulated production of lactate, the rate of /sup 45/Ca/sup 2 +/ efflux, the inhibitory action of glucose upon such an efflux and its increase in response to theophylline. These data are compatible with the view that R33711 inhibits entry of Ca/sup 2 +/ into the B-cell and that integrity of such an inward cationic movement usually plays a permissive role in the maintenance of the Ca/sup 2 +/-dependent insulin secretory process.","","","","","Germany","1976-11-01","","English","Journal Article","","","8:6","Journal Name: Horm. Metab. Res.; (Germany, Federal Republic of); Journal Volume: 8:6; Other Information: 4 figs.; 3 tabs.; 19 refs","","Medium: X; Size: Pages: 434-438","","","","Journal ID: CODEN: HMMRA","https://doi.org/","","2010-12-30","7212884",""