TY - JOUR TI - Parenteral administration of GM1 ganglioside to presenile Alzheimer patients AB - The pharmacokinetic parameters of GM1 ganglioside were examined in 16 patients (mean age 64 {plus minus} 5 years) with Alzheimer's disease. The ganglioside was given intramuscularly and subcutaneously. The maximum GM1 blood level was reached after 48-72 h, the subcutaneous route leading to the highest blood levels, but the individual variability was relatively large. When 100 mg GM1 ganglioside was given daily for a week, maximum serum values of 15 to 20 {sup m}u{sup m}ol/l were found in 3 patients. The elimination half-life from serum was 60-75 h. (author). AU - "Svennerholm, L" AU - "Gottfries, C G" AU - "Blennow, K" AU - "Fredman, P" AU - "Karlsson, I" AU - "Maansson, J -E [Department of Psychiatry and Neurochemistry, Gothenburg University (Sweden)]" AU - "Toffano, G" AU - "Wallin, A [Fidia Research Laboratories, Abano Terme (Italy)]" KW - "63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT." KW - "38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY" KW - "ELDERLY PEOPLE" KW - "MENTAL DISORDERS" KW - "GANGLIOSIDES" KW - "BRAIN" KW - "BOROHYDRIDES" KW - "INTRAMUSCULAR INJECTION" KW - "LABELLING" KW - "TRITIUM COMPOUNDS" KW - "AGE GROUPS" KW - "AGED ADULTS" KW - "BODY" KW - "BORON COMPOUNDS" KW - "CARBOHYDRATES" KW - "CENTRAL NERVOUS SYSTEM" KW - "GLYCOLIPIDS" KW - "HUMAN POPULATIONS" KW - "HYDROGEN COMPOUNDS" KW - "INJECTION" KW - "INTAKE" KW - "LIPIDS" KW - "MINORITY GROUPS" KW - "NERVOUS SYSTEM" KW - "ORGANIC COMPOUNDS" KW - "ORGANS" KW - "POPULATIONS" KW - "SACCHARIDES" KW - "560161* - Radionuclide Effects, Kinetics, & Toxicology- Man" KW - "400703 - Radiochemistry & Nuclear Chemistry- Radioisotope Production" DO - https://doi.org/ UR - PB - CY - Denmark PY - 1990 DA - 1990-01-01 LA - English J2 - [] VL - 81 C1 - C2 - C3 - C4 - C5 - L3 - Journal Name: Acta Neurologica Scandinavica; (Denmark); Journal Volume: 81 ER -