TY - JOUR TI - Use and limitations of radiolabelled anti-CEA antibodies and their fragments for photoscanning detection of human colorectal carcinomas AB - Fifty-three patients with histologically proven carcinoma were injected with highly purified (/sup 131/I)-labelled goat antibodies or fragments of antibodies against carcinoembryonic antigen (CEA). Each patient was tested by external photoscanning 4, 24, 36, 48h after injection. In 22 patients (16 of 38 injected with intact antibodies, 5 of 13 with F(ab')/sub 2/ fragments and 1 of 2 with Fab' fragments), an increased concentration of /sup 131/I radioactivity corresponding to the previously known tumor location was detected by photoscanning 36-48 h after injection. Blood pool and secreted radioactivity was determined in all patients by injecting 15 min after scanning, (sup(99m)Tc)-labeled normal serum albumin and free sup(99m)TcO/sub 4//sup -/. The computerized subtraction of sup(99m)Tc from /sup 131/I radioactivity enhanced the definition of tumor localization in the 22 positive patients. However, in spite of the computerized subtraction, interpretation of the scans remained doubtful for 12 patients and was entirely negative for 19 additional patients. AU - "Mach, J P" AU - "Forni, M" AU - "Ritschard, J" AU - "Buchegger, F" AU - "Carrel, S" AU - "Widgren, S" AU - "Donath, A" AU - "Alberto, P [Lausanne Univ. (Switzerland)]" KW - "62 RADIOLOGY AND NUCLEAR MEDICINE" KW - "ANTIBODIES" KW - "BIOLOGICAL LOCALIZATION" KW - "CARCINOMAS" KW - "RADIOISOTOPE SCANNING" KW - "DIAGNOSTIC TECHNIQUES" KW - "IODINE 131" KW - "LABELLED COMPOUNDS" KW - "MAN" KW - "SPECIFICITY" KW - "TECHNETIUM 99" KW - "ANIMALS" KW - "BETA DECAY RADIOISOTOPES" KW - "BETA-MINUS DECAY RADIOISOTOPES" KW - "COUNTING TECHNIQUES" KW - "DAYS LIVING RADIOISOTOPES" KW - "DISEASES" KW - "HOURS LIVING RADIOISOTOPES" KW - "INTERMEDIATE MASS NUCLEI" KW - "IODINE ISOTOPES" KW - "ISOMERIC TRANSITION ISOTOPES" KW - "ISOTOPES" KW - "MAMMALS" KW - "NEOPLASMS" KW - "NUCLEI" KW - "ODD-EVEN NUCLEI" KW - "PRIMATES" KW - "RADIOISOTOPES" KW - "TECHNETIUM ISOTOPES" KW - "VERTEBRATES" KW - "YEARS LIVING RADIOISOTOPES" KW - "550601* - Medicine- Unsealed Radionuclides in Diagnostics" DO - https://doi.org/ UR - PB - CY - Netherlands PY - 1980 DA - 1980-08-01 LA - English J2 - [] VL - 1:1 C1 - C2 - C3 - C4 - C5 - L3 - Journal Name: Oncodev. Biol. Med.; (Netherlands); Journal Volume: 1:1 ER -