%A"Ishikawa, Masatsune" %A"Kikuchi, Haruhiko" %A"Taki, Waro" %A"Kobayashi, Akira" %A"Nishizawa, Sadahiko" %A"Yonekura, Yoshiharu" %A"Konishi, Junji [Kyoto Univ. (Japan). Faculty of Medicine]" %D1989 %I; %2 %J[] %K62 RADIOLOGY AND NUCLEAR MEDICINE, BRAIN, POSITRON COMPUTED TOMOGRAPHY, OXYGEN 15, BLOOD FLOW, HEMORRHAGE, INHALATION, METABOLISM, NERVOUS SYSTEM DISEASES, OXYGEN, REFERENCE MAN, BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, BODY, CENTRAL NERVOUS SYSTEM, COMPUTERIZED TOMOGRAPHY, DIAGNOSTIC TECHNIQUES, DISEASES, ELEMENTS, EMISSION COMPUTED TOMOGRAPHY, EVEN-ODD NUCLEI, INTAKE, ISOTOPES, LIGHT NUCLEI, MINUTES LIVING RADIOISOTOPES, NERVOUS SYSTEM, NONMETALS, NUCLEI, ORGANS, OXYGEN ISOTOPES, PATHOLOGICAL CHANGES, RADIOISOTOPES, SYMPTOMS, TOMOGRAPHY, 550601* - Medicine- Unsealed Radionuclides in Diagnostics %PMedium: X; Size: Pages: 382-388 %TRegional cerebral blood flow and oxygen metabolism in normal pressure hydrocephalus after subarachnoid hemorrhage %XTo clarify the pathophysiology of normal pressure hydrocephalus (NPH) after subarachnoid hemorrhage, the authors measured cerebral blood flow (CBF), cerebral oxygen metabolic rates (CMRO{sub 2}), the cerebral oxygen extraction fraction (OEF), and cerebral blood volume (CBV) in eight normal volunteers, six SAH patients with NPH, and seven patients without NPH by {sup 15}O-labeled gas and positron emission tomography (PET). In the NPH group, PET revealed a decrease in CBF in the lower regions of the cerebral cortex and a diffuse decrease in CMRO{sub 2}. The decrease in CBF in the lower frontal, temporal, and occipital cortices was significantly greater in the NPH than in the non-NPH group. Reduction of CMRO{sub 2} was also more extensive in the NPH group, and both CBF and CMRO{sub 2} were more markedly decreased in the lower frontal region. OEF was increased in all areas in both of the patient groups, but the increase was not significant in most areas. CBF, CMRO{sub 2} and OEF did not significantly differ between the non-NPH group and the normal volunteers. There was no significant difference in CBV among the three groups. These results indicate that NPH involves impairment of cerebral oxygen metabolism in the lower regions of the cerebral cortex, particularly in the lower frontal region. (author). %0Journal Article %N;Journal ID: ISSN 0387-2572; CODEN: NMCHB %1 %CJapan %Rhttps://doi.org/ Journal ID: ISSN 0387-2572; CODEN: NMCHB JPN %GEnglish