TY - JOUR TI - Studies on brain blood-flow with N-isopropyl-(I-123)p-iodoamphetamine in dementia AB - A differentiation between patients with senile dementia of Alzheimer type (SDAT) and patients with multi-infarct dementia (MID) was attempted in this paper. Twenty normal subjects, 20 SDAT and 20 MID patients were studied with single photon emission computed tomography (SPECT) using N-isopropyl-(I-123)p-iodoamphetamine ({sup 123}I-IMP). SPECT was started 10 minutes after the injection of 3.0 mCi {sup 123}I-IMP. Eight anatomical regions (region of interest, ROI) were examined at the level of the basal ganglia and ten at the level of the centrum semiovale. The count ratio of each ROI to the average was calculated and tested with Student's t-test of mean differences. The ratios of right inferior frontal region and superior frontal region were significantly lower in the SDAT patients than in the normal subjects. The left superior frontal region showed lower mean ratios in SDAT patients, but the difference was not statistically significant. This study supports the suggestion that there is frontal region hypofunction in SDAT patients. SPECT with {sup 123}I-IMP is a useful method in the non-invasive assessment of cerebral pathophysiology in dementia. (author). AU - "Shin, Akinori [Osaka Medical Coll., Takatsuki (Japan)]" KW - "62 RADIOLOGY AND NUCLEAR MEDICINE" KW - "BRAIN" KW - "SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY" KW - "IODINE 123" KW - "BENZEDRINE" KW - "BLOOD FLOW" KW - "CAT SCANNING" KW - "ELDERLY PEOPLE" KW - "MENTAL DISORDERS" KW - "PATIENTS" KW - "REFERENCE MAN" KW - "AGE GROUPS" KW - "AGED ADULTS" KW - "AMINES" KW - "AUTONOMIC NERVOUS SYSTEM AGENTS" KW - "BETA DECAY RADIOISOTOPES" KW - "BODY" KW - "CENTRAL NERVOUS SYSTEM" KW - "COMPUTERIZED TOMOGRAPHY" KW - "DIAGNOSTIC TECHNIQUES" KW - "DRUGS" KW - "ELECTRON CAPTURE RADIOISOTOPES" KW - "EMISSION COMPUTED TOMOGRAPHY" KW - "HOURS LIVING RADIOISOTOPES" KW - "HUMAN POPULATIONS" KW - "INTERMEDIATE MASS NUCLEI" KW - "IODINE ISOTOPES" KW - "ISOTOPES" KW - "MINORITY GROUPS" KW - "NERVOUS SYSTEM" KW - "NUCLEI" KW - "ODD-EVEN NUCLEI" KW - "ORGANIC COMPOUNDS" KW - "ORGANS" KW - "POPULATIONS" KW - "RADIOISOTOPES" KW - "SYMPATHOMIMETICS" KW - "TOMOGRAPHY" KW - "550601* - Medicine- Unsealed Radionuclides in Diagnostics" DO - https://doi.org/ UR - PB - CY - Japan PY - 1989 DA - 1989-06-01 LA - Japanese J2 - [] VL - 48:1 C1 - C2 - C3 - C4 - C5 - L3 - Journal Name: Osaka Ika Daigaku Zasshi; (Japan); Journal Volume: 48:1 ER -