"TITLE","AUTHORS","SUBJECT","SUBJECT_RELATED","DESCRIPTION","PUBLISHER","AVAILABILITY","RESEARCH_ORG","SPONSORING_ORG","PUBLICATION_COUNTRY","PUBLICATION_DATE","CONTRIBUTING_ORGS","LANGUAGE","RESOURCE_TYPE","TYPE_QUALIFIER","JOURNAL_ISSUE","JOURNAL_VOLUME","RELATION","COVERAGE","FORMAT","IDENTIFIER","REPORT_NUMBER","DOE_CONTRACT_NUMBER","OTHER_IDENTIFIER","DOI","RIGHTS","ENTRY_DATE","OSTI_IDENTIFIER","PURL_URL" "Decrease of glucose-induced insulin secretion of pancreatic rat islets after irradiation in vitro","Heinzmann, D; Nadrowitz, R; Besch, W; Schmidt, W; Hahn, H J","63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; PANCREAS; BIOLOGICAL RADIATION EFFECTS; GLUCOSE; HORMONES; IMMUNOSUPPRESSION; IN VITRO; INSULIN; RATS; TISSUE CULTURES; TRANSPLANTS; ALDEHYDES; ANIMALS; BIOLOGICAL EFFECTS; BODY; CARBOHYDRATES; DIGESTIVE SYSTEM; ENDOCRINE GLANDS; GLANDS; HEXOSES; MAMMALS; MONOSACCHARIDES; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; RADIATION EFFECTS; RODENTS; SACCHARIDES; VERTEBRATES; 560121* - Radiation Effects on Cells- External Source- (-1987)","","Irradiation of pancreatic rat islets up to a dose of 2.5 Gy did neither alter glucose-nor IBMX-induced insulin secretion studied in vitro. The insulin as well as glucagon content of irradiated islets were similar as in the control tissue. This was also true in islets irradiated with 25 Gy which were characterized by a decreased insulin secretion in the presence of glucose and IBMX, respectively. Since we did not find indications of an enhanced hormone output in the radiation medium, we want to suggest that higher irradiation doses affect insulin release of pancreatic islets in vitro. This observation has to be taken into account for application of radioimmunosuppression for transplantation.","","","Central Institute of Diabetes, Research and Treatment, Karlsburg, GDR","","Germany","1983-01-01","","English","Journal Article","","","81:1","Journal Name: Exp. Clin. Endocrinol.; (German Democratic Republic); Journal Volume: 81:1","","Medium: X; Size: Pages: 94-97","","","","Journal ID: CODEN: EXCED","https://doi.org/10.1055/s-0029-1210213","","2010-05-03","5272297",""