TY - JOUR TI - Tumor-specific binding of radiolabeled G-22 monoclonal antibody in glioma patients AB - Iodine-131-labeled G-22 monoclonal antibody F(ab'){sub 2} fragment reacting specifically with a glioma-associated surface glycoprotein was administered to 12 glioma patients to investigate its use in radioimaging of intracranial gliomas. No immediate or delayed side effects were attributable to antibody injection. Nine patients received the radiolabeled complex intravenously. The images of low-grade gliomas were generally poor and disappeared within 4 days. High-contrast images were obtained beyond the 7th day in high-grade gliomas except one case in the pineal region. Three patients received intraventricular or intratumoral administration. Clear images of all tumors were demonstrated from the 2nd until later than the 7th day. One patient with cerebrospinal fluid (CSF) dissemination of brainstem glioma demonstrated negative CSF cytology after intraventricular administration. (author). AU - "Yoshida, Jun" AU - "Wakabayashi, Toshihiko" AU - "Mizuno, Masaaki" AU - "Sugita, Kenichiro" AU - "Oshima, Motoo" AU - "Tadokoro, Masanori" AU - "Sakuma, Sadayuki [Nagoya Univ. (Japan). Faculty of Medicine]" AU - "Seo, Hisao" KW - "62 RADIOLOGY AND NUCLEAR MEDICINE" KW - "BRAIN" KW - "RADIOIMMUNODETECTION" KW - "IODINE 131" KW - "MONOCLONAL ANTIBODIES" KW - "AFFINITY" KW - "CEREBROSPINAL FLUID" KW - "GLIOMAS" KW - "GLYCOPROTEINS" KW - "LABELLING" KW - "UPTAKE" KW - "ANTIBODIES" KW - "BETA DECAY RADIOISOTOPES" KW - "BETA-MINUS DECAY RADIOISOTOPES" KW - "BIOLOGICAL MATERIALS" KW - "BODY" KW - "BODY FLUIDS" KW - "CENTRAL NERVOUS SYSTEM" KW - "DAYS LIVING RADIOISOTOPES" KW - "DIAGNOSTIC TECHNIQUES" KW - "DISEASES" KW - "INTERMEDIATE MASS NUCLEI" KW - "IODINE ISOTOPES" KW - "ISOTOPE APPLICATIONS" KW - "ISOTOPES" KW - "MATERIALS" KW - "NEOPLASMS" KW - "NERVOUS SYSTEM" KW - "NUCLEI" KW - "ODD-EVEN NUCLEI" KW - "ORGANIC COMPOUNDS" KW - "ORGANS" KW - "PROTEINS" KW - "RADIOISOTOPES" KW - "TRACER TECHNIQUES" KW - "550601* - Medicine- Unsealed Radionuclides in Diagnostics" DO - https://doi.org/ UR - PB - CY - Japan PY - 1992 DA - 1992-03-01 LA - English J2 - [] VL - 32:3 C1 - C2 - C3 - C4 - C5 - L3 - Journal Name: Neurologia Medico-Chirurgica; (Japan); Journal Volume: 32:3 ER -