TY - JOUR TI - Stroke acute management with urgent risk-factor assessment and improvement (SAMURAI) rt-PA registry. General results and subanalyses AB - Stroke Acute Management with Urgent Risk-factor Assessment and Improvement [SAMURAI] rt-PA Registry is a multicenter retrospective observational study from 10 Japanese stroke centers. A total of 600 patients (223 women, 72{+-}12 years old) treated with intravenous alteplase (0.6 mg/kg) were studied. Symptomatic intracerebral hemorrhage within 36 hours with {>=}4 point-increase from the baseline National Institutes of Health (NIH) Stroke Scale score developed in 8 patients (1.3%, 95% confidence interval (CI) 0.7-2.6%). At 3 months, 199 patients (33.2%, 29.5-37.0%) had a modified Rankin Scale (mRS) score {<=}1. Analysis of 399 patients with a premorbid mRS score {<=}1 who met the criteria of the European license ({<=}80 years old, an initial NIHSS score {<=}24, etc.) showed that 40.6% (35.9-45.5%) had a 3-month mRS {<=}1. In the subanalyses from this registry, early ischemic change on diffusion-weighted imaging assessed by the Alberta Stroke Programme Early CT Score, as well as reduced estimated glomerular filtration rate, was associated with early intracerebral hemorrhage and 3-month outcomes of patients. (author) AU - "Toyoda, Kazunori" AU - "Koga, Masatoshi [National Cerebral and Cardiovascular Center, Suita, Osaka (Japan)]" AU - "Shiokawa, Yoshiaki [Kyorin Univ., School of Medicine, Mitaka, Tokyo (Japan)]" KW - "62 RADIOLOGY AND NUCLEAR MEDICINE" KW - "CAROTID ARTERIES" KW - "CAT SCANNING" KW - "CEREBRAL ARTERIES" KW - "CLINICAL TRIALS" KW - "DIFFUSION" KW - "HEMORRHAGE" KW - "ISCHEMIA" KW - "MULTIVARIATE ANALYSIS" KW - "NMR IMAGING" KW - "PATIENTS" KW - "ANEMIAS" KW - "ARTERIES" KW - "BLOOD VESSELS" KW - "BODY" KW - "CARDIOVASCULAR DISEASES" KW - "CARDIOVASCULAR SYSTEM" KW - "COMPUTERIZED TOMOGRAPHY" KW - "DIAGNOSTIC TECHNIQUES" KW - "DISEASES" KW - "HEMIC DISEASES" KW - "MATHEMATICS" KW - "ORGANS" KW - "PATHOLOGICAL CHANGES" KW - "STATISTICS" KW - "SYMPTOMS" KW - "TESTING" KW - "TOMOGRAPHY" KW - "VASCULAR DISEASES" DO - https://doi.org/10.3995/jstroke.32.756 UR - PB - CY - Japan PY - 2010 DA - 2010-11-15 LA - Japanese J2 - [] VL - 32 C1 - C2 - C3 - C4 - C5 - L3 - Journal Name: No Sotchu; Journal Volume: 32; Journal Issue: 6 ER -