"TITLE","AUTHORS","SUBJECT","SUBJECT_RELATED","DESCRIPTION","PUBLISHER","AVAILABILITY","RESEARCH_ORG","SPONSORING_ORG","PUBLICATION_COUNTRY","PUBLICATION_DATE","CONTRIBUTING_ORGS","LANGUAGE","RESOURCE_TYPE","TYPE_QUALIFIER","JOURNAL_ISSUE","JOURNAL_VOLUME","RELATION","COVERAGE","FORMAT","IDENTIFIER","REPORT_NUMBER","DOE_CONTRACT_NUMBER","OTHER_IDENTIFIER","DOI","RIGHTS","ENTRY_DATE","OSTI_IDENTIFIER","PURL_URL" "Stroke acute management with urgent risk-factor assessment and improvement (SAMURAI) rt-PA registry. General results and subanalyses","Toyoda, Kazunori; Koga, Masatoshi [National Cerebral and Cardiovascular Center, Suita, Osaka (Japan)]; Shiokawa, Yoshiaki [Kyorin Univ., School of Medicine, Mitaka, Tokyo (Japan)]","62 RADIOLOGY AND NUCLEAR MEDICINE; CAROTID ARTERIES; CAT SCANNING; CEREBRAL ARTERIES; CLINICAL TRIALS; DIFFUSION; HEMORRHAGE; ISCHEMIA; MULTIVARIATE ANALYSIS; NMR IMAGING; PATIENTS; ANEMIAS; ARTERIES; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; HEMIC DISEASES; MATHEMATICS; ORGANS; PATHOLOGICAL CHANGES; STATISTICS; SYMPTOMS; TESTING; TOMOGRAPHY; VASCULAR DISEASES","ANEMIAS; ARTERIES; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; HEMIC DISEASES; MATHEMATICS; ORGANS; PATHOLOGICAL CHANGES; STATISTICS; SYMPTOMS; TESTING; TOMOGRAPHY; VASCULAR DISEASES","Stroke Acute Management with Urgent Risk-factor Assessment and Improvement [SAMURAI] rt-PA Registry is a multicenter retrospective observational study from 10 Japanese stroke centers. A total of 600 patients (223 women, 72{+-}12 years old) treated with intravenous alteplase (0.6 mg/kg) were studied. Symptomatic intracerebral hemorrhage within 36 hours with {>=}4 point-increase from the baseline National Institutes of Health (NIH) Stroke Scale score developed in 8 patients (1.3%, 95% confidence interval (CI) 0.7-2.6%). At 3 months, 199 patients (33.2%, 29.5-37.0%) had a modified Rankin Scale (mRS) score {<=}1. Analysis of 399 patients with a premorbid mRS score {<=}1 who met the criteria of the European license ({<=}80 years old, an initial NIHSS score {<=}24, etc.) showed that 40.6% (35.9-45.5%) had a 3-month mRS {<=}1. In the subanalyses from this registry, early ischemic change on diffusion-weighted imaging assessed by the Alberta Stroke Programme Early CT Score, as well as reduced estimated glomerular filtration rate, was associated with early intracerebral hemorrhage and 3-month outcomes of patients. (author)","","","","","Japan","2010-11-15","","Japanese","Journal Article","","6","32","Journal Name: No Sotchu; Journal Volume: 32; Journal Issue: 6","","Medium: X; Size: page(s) 756-761","","","","Journal ID: ISSN 0912-0726; TRN: JP1102029063162","https://doi.org/10.3995/jstroke.32.756","","2012-12-22","21469910",""