"TITLE","AUTHORS","SUBJECT","SUBJECT_RELATED","DESCRIPTION","PUBLISHER","AVAILABILITY","RESEARCH_ORG","SPONSORING_ORG","PUBLICATION_COUNTRY","PUBLICATION_DATE","CONTRIBUTING_ORGS","LANGUAGE","RESOURCE_TYPE","TYPE_QUALIFIER","JOURNAL_ISSUE","JOURNAL_VOLUME","RELATION","COVERAGE","FORMAT","IDENTIFIER","REPORT_NUMBER","DOE_CONTRACT_NUMBER","OTHER_IDENTIFIER","DOI","RIGHTS","ENTRY_DATE","OSTI_IDENTIFIER","PURL_URL" "Possible Outcome of Fenugreek Seeds Powder Administration on the Fertility of Female and Male Albino Rat","Ibrahim, M F; El-Tawill, G.A., E-mail: gkyrillos@hotmail.co [Radiation Biology Department, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo (Egypt)]","60 APPLIED LIFE SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BLOOD SERUM; CHOLESTEROL; ERYTHROCYTES; FEMALES; FERTILITY; FSH; HORMONES; INFLAMMATION; INSULIN; LEGUMINOSAE; MALES; OVARIES; RADIOIMMUNOASSAY; RATS; SEEDS; TESTES; TESTOSTERONE; ANDROGENS; ANDROSTANES; ANIMALS; BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BLOOD PLASMA; BODY; BODY FLUIDS; DIAGNOSTIC TECHNIQUES; FEMALE GENITALS; GONADOTROPINS; GONADS; HYDROXY COMPOUNDS; IMMUNOASSAY; ISOTOPE APPLICATIONS; KETONES; MAGNOLIOPHYTA; MAGNOLIOPSIDA; MALE GENITALS; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PEPTIDE HORMONES; PITUITARY HORMONES; PLANTS; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; RODENTS; STEROID HORMONES; STEROIDS; STEROLS; SYMPTOMS; TRACER TECHNIQUES; VERTEBRATES","ANDROGENS; ANDROSTANES; ANIMALS; BIOASSAY; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BLOOD PLASMA; BODY; BODY FLUIDS; DIAGNOSTIC TECHNIQUES; FEMALE GENITALS; GONADOTROPINS; GONADS; HORMONES; HYDROXY COMPOUNDS; IMMUNOASSAY; ISOTOPE APPLICATIONS; KETONES; MAGNOLIOPHYTA; MAGNOLIOPSIDA; MALE GENITALS; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PEPTIDE HORMONES; PITUITARY HORMONES; PLANTS; PROTEINS; RADIOASSAY; RADIOIMMUNODETECTION; RODENTS; STEROID HORMONES; STEROIDS; STEROLS; SYMPTOMS; TRACER TECHNIQUES; VERTEBRATES","Fenugreek (Trigonella foenum-graecum) is an annual plant from the family of Papilionaceae-Leguminosae that has been credited with many medicinal properties. The current study aims to evaluate the possible fertility activity of fenugreek seeds powder on female and male albino rats. To achieve the theme, fenugreek seeds powder (200 mg/rat) were daily administered orally to both female and male Wistar rats for 15 and 30 consecutive days, after which the rats were sacrificed for both biochemical and histopathological observations. Fenugreek treatment significantly decreased the serum cholesterol levels in both female and male rats with a marked increase in the ovary and testis cholesterol levels following 30 days of consecutive administration. The circulating serum female hormones showed an initial elevation at the end of 15 days of fenugreek intake followed by a significant drop in the group of rats that continued to receive the daily fenugreek dose for 30 days. These observations were supported by the notable decline in the ovarian weights further validated by their ovarian histological sections revealing remarkable dissolution of some follicles and prominent abundance of inflammatory cells. In the 30 days interval treated males, the serum testosterone hormone concentrations significantly declined and the testis weights were reduced with evident damage to the seminiferous tubules and interstitial tissues as shown by the histopathological picture of testis tissue sections. Accordingly, it can be deduced that fenugreek seeds powder exert a significant antifertility adverse effect on the female and male rats when supplemented at a considerable dose for an extended time interval","","","","","Egypt","2010-07-01","","English","Journal Article","","2A","3","Journal Name: Journal of Radiation Research and Applied Sciences; Journal Volume: 3; Journal Issue: 2A","","Medium: X; Size: page(s) 357-372","","","","Journal ID: ISSN 1687-8507; TRN: EG1100328050636","https://doi.org/","","2012-12-22","21455545",""