%A"Mauderly, J L" %A"Madron, E de" %A"Harkema, J R" %D1988 %I; Inhalation Toxicology Research Institute, Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (United States) %2Office of Health and Environmental Research, U.S. Department of Energy (United States) %J[] %K60 APPLIED LIFE SCIENCES, BIOLOGICAL EFFECTS, BRONCHOPNEUMONIA, INFLAMMATION, LUNGS, OZONE, PATHOLOGY, PHENOBARBITAL, RATS, TOXICITY %PMedium: ED; Size: page(s) 439-447 %TLung structure-respiratory function relationships in experimentally-induced bronchiolitis, bronchopneumonia and interstitial pneumonia in rats %XHistopathology and respiratory function of rats with three different types and distributions of lower lung inflammation were compared to better understand lung structure-function relationships. Rats were exposed 21 h/day for 7 days to 0.8 ppm ozone (O{sub 3}), sham-exposed as controls, or given 5 mg/kg bacterial endotoxin either intratracheally (ITE) or intraperitoneally (IPE). Respiratory function was measured 24 h after the end of treatment, than the rats were sacrificed and the distribution of inflammation was evaluated morphometrically. Chronic centriacinar inflammation with formation of new respiratory bronchioles caused an obstructive functional impairment in the O{sub 3} rats, which was clearly distinguished from the restrictive impairments resulting from acute inflammation in ITE and IPE rats. Only the magnitudes of changes related to the distribution of inflammation differentiated the ITE and IPE groups. Flow parameters previously thought sensitive to large airway resistance were changed in the O{sub 3} rats. Alveolar luminal inflammatory exudate affected quasistatic compliance more than septal inflammation in ITE and IPE rats. Quasistatic chord compliance was the most sensitive of three indices of pressure-volume relationships. The findings in this study improve the basis for interpreting respiratory function changes of rats. (author) %0Technical Report %NLMF-121; INIS-XA-N-170;Other: Contract DE-AC04-76EV01013; TRN: XA04N1401003665 %1 %CIAEA %Rhttps://doi.org/ Other: Contract DE-AC04-76EV01013; TRN: XA04N1401003665 INIS %GEnglish