{
  "date" : "2003-08-01",
  "identifier_doecontract" : "",
  "subject" : "62 RADIOLOGY AND NUCLEAR MEDICINE; DIAGNOSIS; PATIENTS; BRAIN; FLUORINE 18; FLUORODEOXYGLUCOSE; UPTAKE; RADIOPHARMACEUTICALS; POSITRON COMPUTED TOMOGRAPHY; METABOLISM; NERVOUS SYSTEM DISEASES; GLUCOSE",
  "description" : "A high percentage of patients with mild cognitive impairment (MCI) develop clinical dementia of the Alzheimer type (AD) within 1 year. The aim of this longitudinal study was to identify characteristic patterns of cerebral metabolism at baseline in patients converting from MCI to AD, and to evaluate the changes in these patterns over time. Baseline and follow-up examinations after 1 year were performed in 22 MCI patients (12 males, 10 females, aged 69.8{+-}5.8 years); these examinations included neuropsychological testing, structural cranial magnetic resonance imaging and fluorine-18 fluorodeoxyglucose positron emission tomography (PET) evaluation of relative cerebral glucose metabolic rate (rCMRglc). Individual PET scans were stereotactically normalised with NEUROSTAT software (Univ. of Michigan, Ann Arbor, USA). Subsequently, statistical comparison of PET data with an age-matched healthy control population and between patient subgroups was performed using SPM 99 (Wellcome Dept. of Neuroimaging Sciences, London, UK). After 1 year, eight patients (36%) had developed probable AD (referred to as MCI{sub AD}), whereas 12 (55%) were still classified as having stable MCI (referred to as MCI{sub MCI}). Compared with the healthy control group, a reduced rCMRglc in AD-typical regions, including the temporoparietal and posterior cingulate cortex, was detected at baseline in patients with MCI{sub AD}. Abnormalities in the posterior cingulate cortex reached significance even in comparison with the MCI{sub MCI} group. After 1 year, MCI{sub AD} patients demonstrated an additional bilateral reduction of rCMRglc in prefrontal areas, along with a further progression of the abnormalities in the parietal and posterior cingulate cortex. No such changes were observed in the MCI{sub MCI} group. In patients with MCI, characteristic cerebral metabolic differences can be delineated at the time of initial presentation, which helps to define prognostic subgroups. A newly emerging reduction of rCMRglc in prefrontal cortical areas is associated with the transition from MCI to AD. (orig.)",
  "language" : "English",
  "identifier_report" : "",
  "publisher_sponsor" : "",
  "publisher_country" : "Germany",
  "source" : "DEN",
  "purl" : "",
  "title" : "Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study",
  "type" : "Journal Article",
  "subject_related" : "",
  "relation" : "Journal Name: European Journal of Nuclear Medicine and Molecular Imaging; Journal Volume: 30; Journal Issue: 8; Other Information: PBD: Aug 2003",
  "entry_date" : "2010-12-31",
  "subject_list" : [ "62 RADIOLOGY AND NUCLEAR MEDICINE", "DIAGNOSIS", "PATIENTS", "BRAIN", "FLUORINE 18", "FLUORODEOXYGLUCOSE", "UPTAKE", "RADIOPHARMACEUTICALS", "POSITRON COMPUTED TOMOGRAPHY", "METABOLISM", "NERVOUS SYSTEM DISEASES", "GLUCOSE" ],
  "publisher_availability" : "Available from: http://dx.doi.org/10.1007/s00259-003-1194-1",
  "rights" : "",
  "announced_date" : "2003-12-12",
  "type_qualifier" : "",
  "has_fulltext" : false,
  "coverage" : "",
  "identifier" : "",
  "journal_volume" : "30",
  "creator" : "Drzezga, Alexander; Willoch, Frode; Schwaiger, Markus [Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitaet Muenchen, Ismaninger Strasse 22, 81675, Muenchen (Germany)]; Lautenschlager, Nicola; Riemenschneider, Matthias; Kurz, Alexander [Department of Psychiatry and Psychotherapy, Technische Universitaet Muenchen, Muenchen (Germany)]; Siebner, Hartwig [Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London (United Kingdom)]; Minoshima, Satoshi [Department of Radiology, University of Washington, Seattle, WA (United States)]",
  "site_ownership_code" : "DEN",
  "osti_id" : "20407218",
  "journal_issue" : "8",
  "resource_type" : "JOUR",
  "format" : "Medium: X; Size: page(s) 1104-1113",
  "journal_name" : [ ],
  "contributing_organizations" : "",
  "citation_location" : "https://www.osti.gov/etdeweb/biblio/20407218",
  "publication_year" : 2003,
  "subject_list_commas" : "62 RADIOLOGY AND NUCLEAR MEDICINE, DIAGNOSIS, PATIENTS, BRAIN, FLUORINE 18, FLUORODEOXYGLUCOSE, UPTAKE, RADIOPHARMACEUTICALS, POSITRON COMPUTED TOMOGRAPHY, METABOLISM, NERVOUS SYSTEM DISEASES, GLUCOSE",
  "publisher" : "",
  "identifier_other" : "Journal ID: ISSN 1619-7070; TRN: DE03FD764",
  "publisher_research" : "",
  "creators_list" : [ "Drzezga, Alexander", "Willoch, Frode", "Schwaiger, Markus [Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitaet Muenchen, Ismaninger Strasse 22, 81675, Muenchen (Germany)]", "Lautenschlager, Nicola", "Riemenschneider, Matthias", "Kurz, Alexander [Department of Psychiatry and Psychotherapy, Technische Universitaet Muenchen, Muenchen (Germany)]", "Siebner, Hartwig [Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London (United Kingdom)]", "Minoshima, Satoshi [Department of Radiology, University of Washington, Seattle, WA (United States)]" ],
  "doi" : "https://doi.org/10.1007/s00259-003-1194-1"
}