"TITLE","AUTHORS","SUBJECT","SUBJECT_RELATED","DESCRIPTION","PUBLISHER","AVAILABILITY","RESEARCH_ORG","SPONSORING_ORG","PUBLICATION_COUNTRY","PUBLICATION_DATE","CONTRIBUTING_ORGS","LANGUAGE","RESOURCE_TYPE","TYPE_QUALIFIER","JOURNAL_ISSUE","JOURNAL_VOLUME","RELATION","COVERAGE","FORMAT","IDENTIFIER","REPORT_NUMBER","DOE_CONTRACT_NUMBER","OTHER_IDENTIFIER","DOI","RIGHTS","ENTRY_DATE","OSTI_IDENTIFIER","PURL_URL" "Effects of radiation on erythropoiesis","Harriss, E B","63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; BLOOD FORMATION; BONE MARROW; HEMATOPOIETIC SYSTEM; IONIZATION; IRRADIATION; LET; MORTALITY; RADIATION SYNDROME; WHOLE-BODY IRRADIATION","","Since the pioneer work of Heineke (1903; 1905) many workers have studied the effect of radiation on haemopoiesis. Their work has been reviewed by Bloom (1948), by Jacobson (1954) and more recently by Bond et al. (1965). The subject continues to stimulate much interest but is now more concerned with the effects of radiation on the multipotential stem cell pool than on radiation damage to the erythropoietic cells themselves. Death from haemopoietic failure following an LD{sub 50/30} dose of radiation is probably not attributable to failure of erythropoiesis; while damage to the erythropoietic system certainly plays a part in the syndrome, it is not a major factor contributing to the death of the animal. Although the severity and time course of the response vary with the species studied, the general effects of radiation on erythropoiesis are similar in all mammalian bone marrow studied to date. Likewise, though the severity of the reaction varies somewhat with the energy of the radiation and has been used to compare the relative biological effectiveness of different types of radiation (Sinclair et al., 1962; Sztanyik, 1967), the response is different only in degree and not in its fundamental pattern. The initial syndrome of depression and recovery will therefore be described largely by reference to work performed on the response of the rat to single acute exposures of either whole-body or partial-body irradiation with conventional X-rays.","IAEA, Vienna (Austria)","","International Atomic Energy Agency, Vienna (Austria); World Health Organization, Geneva (Switzerland)","","IAEA","1971-04-01","","English","Miscellaneous","","","","Other Information: 7 figs; PBD: Apr 1971; Related Information: In: Manual on radiation haematology, Technical reports seriesno. 123, 441 pages.","","Medium: X; Size: page(s) 99-107","","STI/DOC-10/123","","TRN: XA0302295066372","https://doi.org/","","2008-02-08","20386444",""