TY - JOUR TI - Regional magnetic resonance spectroscopy of the brain in autistic individuals AB - We studied the variations in the concentration of metabolites with brain region and age in autistic individuals and normal controls using multiple analysis of covariance. We examined 55 autistic individuals (2-21 years old, 47 male and eight female) and 51 normal children (3 months-15 years old, 26 boys and 25 girls). Single volumes of interest were placed in the frontal, parietal and temporal region on both sides, the brain stem and cingulate gyrus. The concentration of each metabolite was quantified by the water reference method. The concentration of N-acetylaspartate in the temporal regions (Brodmann's areas 41 and 42) in the autistic individuals were significantly lower than those in the controls (P < 0.05), but concentrations in other regions were not significantly different between the autistic individuals and controls. This suggests low density or dysfunction of neurones in Brodmann's areas 41 and 42 in autistic individual, which might be related to the disturbances of the sensory speech centre (Wernicke's area) in autism. (orig.) AU - "Hisaoka, S" AU - "Harada, M" AU - "Nishitani, H [Dept. of Radiology, School of Medicine, University of Tokushima (Japan)]" AU - "Mori, K [Dept. of Paediatrics, School of Medicine, University of Tokushima (Japan)]" KW - "62 RADIOLOGY AND NUCLEAR MEDICINE" KW - "NMR IMAGING" KW - "BRAIN" KW - "MENTAL DISORDERS" KW - "METABOLITES" KW - "STATISTICS" KW - "NERVES" DO - https://doi.org/10.1007/s002340000520 UR - PB - CY - Germany PY - 2001 DA - 2001-06-01 LA - English J2 - [] VL - 43 C1 - C2 - C3 - C4 - C5 - L3 - Journal Name: Neuroradiology; Journal Volume: 43; Journal Issue: 6; Other Information: With 3 figs., 2 tabs., 5 refs.; PBD: Jun 2001 ER -