"TITLE","AUTHORS","SUBJECT","SUBJECT_RELATED","DESCRIPTION","PUBLISHER","AVAILABILITY","RESEARCH_ORG","SPONSORING_ORG","PUBLICATION_COUNTRY","PUBLICATION_DATE","CONTRIBUTING_ORGS","LANGUAGE","RESOURCE_TYPE","TYPE_QUALIFIER","JOURNAL_ISSUE","JOURNAL_VOLUME","RELATION","COVERAGE","FORMAT","IDENTIFIER","REPORT_NUMBER","DOE_CONTRACT_NUMBER","OTHER_IDENTIFIER","DOI","RIGHTS","ENTRY_DATE","OSTI_IDENTIFIER","PURL_URL" "Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging of bone marrow in healthy individuals","Hillengass, Jens [Dept. of Radiology, German Cancer Research Center, Heidelberg (Germany)]; Dept. of Hematology, Oncology and Rheumatology, Univ. of Heidelberg (Germany)), e-mail: j.hillengass@dkfz.de; Stieltjes, Bram [Dept. of Radiology, German Cancer Research Center, Heidelberg (Germany)]; Baeuerle, Tobias [Dept. of Medical Physics in Radiology, German Cancer Research Center, Heidelberg (Germany); and others]","62 RADIOLOGY AND NUCLEAR MEDICINE; BONE MARROW; DIFFUSION; NMR IMAGING; VERTEBRAE; CONTRAST MEDIA","","Background: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) displays microcirculation and permeability by application of contrast-media and diffusion-weighted imaging (DWI) is a tool for quantification of cellularity in the investigated area. Recently published examples cover breast cancer, CNS tumors, head and neck cancer, gastrointestinal cancer, prostate cancer as well as hematologic malignancies. Purpose: To investigated the influence of age, sex, and localization of the investigated region on findings of DCE-MRI and DWI. Material and Methods: DCE-MRI-parameters amplitude A and exchange rate constant kep as well as the DWI-parameter ADC of the bone marrow of the lumbar vertebral column of 30 healthy individuals covering the typical range of age of tumor patients were evaluated. ADC was calculated using b=0 and a maximal b value of either 400 or 750 s/mm2. Results: Amplitude A of DCE-MRI decreased with age (P = 0.01) and amplitude A, exchange rate constant kep as well as ADC based on b = 400 s/mm2 and b = 750 s/mm2, respectively, decreased significantly from the first to the fifth lumbar vertebra with P = 0.02, P = 0.05, P = 0.003, and P = 0.002, respectively. Conclusion: Quantitative parameters of functional imaging techniques in bone marrow are influenced by the age of the examined individual and the anatomical location of the investigated region","","Available from DOI: http://dx.doi.org/10.1258/ar.2010.100366","","","Sweden","2011-04-15","","English","Journal Article","","3","52","Journal Name: Acta Radiologica (online); Journal Volume: 52; Journal Issue: 3; Other Information: refs., figs., tabs.; 10.1258/AR.2010.100366","","Medium: X; Size: page(s) 324-330","","","","Journal ID: ISSN 1600-0455; TRN: SE1108065","https://doi.org/10.1258/AR.2010.100366","","2012-12-20","1011577",""