Title: Methods of treating parkinson's disease using viral vectors

Abstract

Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.

Inventors:

Bankiewicz, Krys ^[1]; Cunningham, Janet ^[2]

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+ Show Inventor Affiliations

1. Garrett Park, MD
2. Alameda, CA

Issue Date:

Tue May 19 00:00:00 EDT 2009

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

988144

Patent Number(s):

7534613

Application Number:

11/102,521

Assignee:

Genzyme Corporation (Cambridge, MA); The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A61K31/198 - Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61K35/761 - Adenovirus
A61K38/45 - Transferases
A61K38/51 - Lyases
A61K45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K47/6901 - {Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors}
A61K48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases
A61K48/0025 - {wherein the non-active part clearly interacts with the delivered nucleic acid}
A61K48/0075 - {characterised by an aspect of the delivery route, e.g. oral, subcutaneous}
A61K51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo
A61K51/0402 - {carboxylic acid carriers, fatty acids
A61K9/5184 - {Virus capsids or envelopes enclosing drugs

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

A61P25/16 - Anti-Parkinson drugs

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C12N15/63 - Introduction of foreign genetic material using vectors
C12N15/86 - Viral vectors
C12N2750/14142 - virus or viral particle as vehicle, e.g. encapsulating small organic molecule
C12N2750/14143 - viral genome or elements thereof as genetic vector
C12N7/00 - Viruses

C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES

C12Y401/01028 - Aromatic-L-amino-acid decarboxylase

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DOE Contract Number:  

AC02-05CH11231

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

60 APPLIED LIFE SCIENCES