Method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation in conjunction with mass spectrometric analysis

Laskin, Julia; Futrell, Jean H

Advanced Search OptionsAdvanced Search queries use a traditional Term Search. For more info, see our FAQ.

All Fields:

Patent Title:

Abstract:

Assignee:

Inventor(s):

Patent Number:

Patent Classification (CPC):

All Classifications
A - human necessities
A01 - agriculture
A21 - baking
A22 - butchering
A23 - foods or foodstuffs
A24 - tobacco
A41 - wearing apparel
A42 - headwear
A43 - footwear
A44 - haberdashery
A45 - hand or travelling articles
A46 - brushware
A47 - furniture
A61 - medical or veterinary science
A62 - life-saving
A63 - sports
A99 - subject matter not otherwise provided for in this section
B - performing operations
B01 - physical or chemical processes or apparatus in general
B02 - crushing, pulverising, or disintegrating
B03 - separation of solid materials using liquids or using pneumatic tables or jigs
B04 - centrifugal apparatus or machines for carrying-out physical or chemical processes
B05 - spraying or atomising in general
B06 - generating or transmitting mechanical vibrations in general
B07 - separating solids from solids
B08 - cleaning
B09 - disposal of solid waste
B21 - mechanical metal-working without essentially removing material
B22 - casting
B23 - machine tools
B24 - grinding
B25 - hand tools
B26 - hand cutting tools
B27 - working or preserving wood or similar material
B28 - working cement, clay, or stone
B29 - working of plastics
B30 - presses
B31 - making articles of paper, cardboard or material worked in a manner analogous to paper
B32 - layered products
B33 - additive manufacturing technology
B41 - printing
B42 - bookbinding
B43 - writing or drawing implements
B44 - decorative arts
B60 - vehicles in general
B61 - railways
B62 - land vehicles for travelling otherwise than on rails
B63 - ships or other waterborne vessels
B64 - aircraft
B65 - conveying
B66 - hoisting
B67 - opening, closing {or cleaning} bottles, jars or similar containers
B68 - saddlery
B81 - microstructural technology
B82 - nanotechnology
B99 - subject matter not otherwise provided for in this section
C - chemistry
C01 - inorganic chemistry
C02 - treatment of water, waste water, sewage, or sludge
C03 - glass
C04 - cements
C05 - fertilisers
C06 - explosives
C07 - organic chemistry
C08 - organic macromolecular compounds
C09 - dyes
C10 - petroleum, gas or coke industries
C11 - animal or vegetable oils, fats, fatty substances or waxes
C12 - biochemistry
C13 - sugar industry
C14 - skins
C21 - metallurgy of iron
C22 - metallurgy
C23 - coating metallic material
C25 - electrolytic or electrophoretic processes
C30 - crystal growth
C40 - combinatorial technology
C99 - subject matter not otherwise provided for in this section
D - textiles
D01 - natural or man-made threads or fibres
D02 - yarns
D03 - weaving
D04 - braiding
D05 - sewing
D06 - treatment of textiles or the like
D07 - ropes
D10 - indexing scheme associated with sublasses of section d, relating to textiles
D21 - paper-making
D99 - subject matter not otherwise provided for in this section
E - fixed constructions
E01 - construction of roads, railways, or bridges
E02 - hydraulic engineering
E03 - water supply
E04 - building
E05 - locks
E06 - doors, windows, shutters, or roller blinds in general
E21 - earth drilling
E99 - subject matter not otherwise provided for in this section
F - mechanical engineering
F01 - machines or engines in general
F02 - combustion engines
F03 - machines or engines for liquids
F04 - positive - displacement machines for liquids
F05 - indexing schemes relating to engines or pumps in various subclasses of classes f01-f04
F15 - fluid-pressure actuators
F16 - engineering elements and units
F17 - storing or distributing gases or liquids
F21 - lighting
F22 - steam generation
F23 - combustion apparatus
F24 - heating
F25 - refrigeration or cooling
F26 - drying
F27 - furnaces
F28 - heat exchange in general
F41 - weapons
F42 - ammunition
F99 - subject matter not otherwise provided for in this section
G - physics
G01 - measuring
G02 - optics
G03 - photography
G04 - horology
G05 - controlling
G06 - computing
G07 - checking-devices
G08 - signalling
G09 - education
G10 - musical instruments
G11 - information storage
G12 - instrument details
G16 - information and communication technology [ict] specially adapted for specific application fields
G21 - nuclear physics
G99 - subject matter not otherwise provided for in this section
H - electricity
H01 - basic electric elements
H02 - generation
H03 - basic electronic circuitry
H04 - electric communication technique
H05 - electric techniques not otherwise provided for
H99 - subject matter not otherwise provided for in this section
Y - new / cross sectional technologies
Y02 - technologies or applications for mitigation or adaptation against climate change
Y04 - information or communication technologies having an impact on other technology areas
Y10 - technical subjects covered by former uspc

More Options ...

Title: Method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation in conjunction with mass spectrometric analysis

Abstract

The invention relates to a method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation (SID) in conjunction with mass spectrometric analysis. Results demonstrate formation of a wide distribution of structure-specific fragments having wide sequence coverage useful for sequencing and identifying the complex molecules.

Inventors:

Laskin, Julia ^[1]; Futrell, Jean H ^[1]

Richland, WA

Issue Date:: Tue Apr 29 00:00:00 EDT 2008

Research Org.:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 985154

Patent Number(s):: 7365312

Application Number:: 11/605,881

Assignee:: Battelle Memorial Institute (Richland, WA)

Patent Classifications (CPCs):: H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

Show more

H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/0068 - {by collision with a surface, e.g. surface induced dissociation}

Show less

DOE Contract Number:: AC06-76RL01830

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Laskin, Julia, and Futrell, Jean H. Method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation in conjunction with mass spectrometric analysis.  United States: N. p., 2008. 
        Web.

Copy to clipboard


                    Laskin, Julia, & Futrell, Jean H. Method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation in conjunction with mass spectrometric analysis.  United States.

Copy to clipboard


                    Laskin, Julia, and Futrell, Jean H. Tue .  
        "Method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation in conjunction with mass spectrometric analysis".  United States.  https://www.osti.gov/servlets/purl/985154.

Copy to clipboard


                    
@article{osti_985154,

  title        = {Method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation in conjunction with mass spectrometric analysis},

  author       = {Laskin, Julia and Futrell, Jean H},

  abstractNote = {The invention relates to a method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation (SID) in conjunction with mass spectrometric analysis. Results demonstrate formation of a wide distribution of structure-specific fragments having wide sequence coverage useful for sequencing and identifying the complex molecules.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Apr 29 00:00:00 EDT 2008},

  month        = {Tue Apr 29 00:00:00 EDT 2008}

}

Copy to clipboard

Patent:

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Proposal for an analytical form of the collisional energy deposition probability
journal, February 1987

Lee, S. H.; Kim, M. S.; Beynon, J. H.
International Journal of Mass Spectrometry and Ion Processes, Vol. 75, Issue 1
https://doi.org/10.1016/0168-1176(87)83065-3

Intra-ionic interactions in electrosprayed peptide ions
journal, March 1997

Summerfield, Scott G.; Whiting, Andrew; Gaskell, Simon J.
International Journal of Mass Spectrometry and Ion Processes, Vol. 162, Issue 1-3
https://doi.org/10.1016/S0168-1176(96)04512-0

Dissociative and Reactive Hyperthermal Ion−Surface Collisions with Langmuir−Blodgett Films Terminated by CF ₃ (CH ₂ ) _n −, n -Perfluoroalkyl, or n -Alkyl Groups
journal, November 1999

Gu, Chungang; Wysocki, Vicki H.; Harada, Atsuhiro
Journal of the American Chemical Society, Vol. 121, Issue 45
https://doi.org/10.1021/ja990719a

Matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry with pulsed in-source collision gas and in-source ion accumulation
journal, January 2000

Baykut, G.; Jertz, Roland; Witt, Matthias
Rapid Communications in Mass Spectrometry, Vol. 14, Issue 14, p. 1238-1247
URL: 10.1002/1097-0231(20000730)14:14<1238::AID-RCM17>3.0.CO;2-H

A High-performance Modular Data System for Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
journal, November 1996

Senko, Michael W.; Canterbury, Jesse D.; Guan, Shenheng
Rapid Communications in Mass Spectrometry, Vol. 10, Issue 14, p. 1839-1844
URL: 10.1002/(SICI)1097-0231(199611)10:14<1839::AID-RCM718>3.0.CO;2-V

Shattering of Peptide Ions on Self-Assembled Monolayer Surfaces
journal, February 2003

Laskin, Julia; Bailey, Thomas H.; Futrell, Jean H.
Journal of the American Chemical Society, Vol. 125, Issue 6
https://doi.org/10.1021/ja027915t

Dynamics of Energy Transfer in Peptide−Surface Collisions
journal, February 2002

Meroueh, Oussama; Hase, William L.
Journal of the American Chemical Society, Vol. 124, Issue 7
https://doi.org/10.1021/ja011987n

Collisional activation of peptide ions in FT-ICR mass spectrometry
journal, January 2003

Laskin, Julia; Futrell, Jean H.
Mass Spectrometry Reviews, Vol. 22, Issue 3
https://doi.org/10.1002/mas.10041

High pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry for minimization of ganglioside fragmentation
journal, April 2002

O’Connor, Peter B.; Mirgorodskaya, Ekaterina; Costello, Catherine E.
Journal of the American Society for Mass Spectrometry, Vol. 13, Issue 4
https://doi.org/10.1016/S1044-0305(02)00351-3

A novel ion funnel for focusing ions at elevated pressure using electrospray ionization mass spectrometry
journal, October 1997

Schaffer, Scott A.; Tang, Keqi; Anderson, Gordon A.
Rapid Communications in Mass Spectrometry, Vol. 11, Issue 16, p. 1813-1817
URL: 10.1002/(SICI)1097-0231(19971030)11:16<1813::AID-RCM87>3.0.CO;2-D

Low energy collision induced dissociation: phase-shifting excitation control of ion kinetic energy in ion cyclotron resonance spectrometry
journal, September 1992

Boering, Kristie A.; Rolfe, Joseph; Brauman, John I.
International Journal of Mass Spectrometry and Ion Processes, Vol. 117
https://doi.org/10.1016/0168-1176(92)80103-8

Dissociative scattering of polyatomic ions from a liquid surface: CF3+ on a perfluoropolyether film
journal, December 1997

Koppers, Wim R.; Beijersbergen, Jaap H. M.; Weeding, Tina L.
The Journal of Chemical Physics, Vol. 107, Issue 24
https://doi.org/10.1063/1.474189

Surface-Induced Dissociation of Multiply-Protonated Proteins
journal, March 1995

Chorush, Russell A.; Little, Daniel P.; Beu, Steven C.
Analytical Chemistry, Vol. 67, Issue 6
https://doi.org/10.1021/ac00102a004

Surface impact induced shattering of C6. Detection of small Cm fragments by negative surface ionization
journal, August 1996

Beck, Rainer D.; Warth, Carmen; May, Klaus
Chemical Physics Letters, Vol. 257, Issue 5-6
https://doi.org/10.1016/0009-2614(96)00587-8

Preferential Fragmentation of Protonated Gas-Phase Peptide Ions Adjacent to Acidic Amino Acid Residues
journal, May 1995

Qin, Jun; Chait, Brian T.
Journal of the American Chemical Society, Vol. 117, Issue 19
https://doi.org/10.1021/ja00124a045

Reactions of ions with organic surfaces
journal, November 1994

Cooks, R. G.; Ast, T.; Pradeep, T.
Accounts of Chemical Research, Vol. 27, Issue 11
https://doi.org/10.1021/ar00047a001

“Linearizing” an ion cyclotron resonance cell
journal, December 2002

Barlow, S. E.; Tinkle, Mark D.
Review of Scientific Instruments, Vol. 73, Issue 12
https://doi.org/10.1063/1.1518787

Identification of the facile gas-phase cleavage of the Asp-Pro and Asp-Xxx peptide bonds in matrix-assisted laser desorption time-of-flight mass spectrometry
journal, November 1993

Yu, Wen.; Vath, James E.; Huberty, Michael C.
Analytical Chemistry, Vol. 65, Issue 21
https://doi.org/10.1021/ac00069a014

Surface-Induced Dissociation in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: Instrument Design and Evaluation
journal, July 2002

Laskin, Julia; Denisov, Eduard V.; Shukla, Anil K.
Analytical Chemistry, Vol. 74, Issue 14
https://doi.org/10.1021/ac025514q

A high pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry ion source for thermal stabilization of labile biomolecules
journal, January 2001

O'Connor, Peter B.; Costello, Catherine E.
Rapid Communications in Mass Spectrometry, Vol. 15, Issue 19
https://doi.org/10.1002/rcm.447

Energy transfer in collisions of peptide ions with surfaces
journal, August 2003

Laskin, Julia; Futrell, Jean H.
The Journal of Chemical Physics, Vol. 119, Issue 6
https://doi.org/10.1063/1.1589739

Surface-induced Dissociation: An Effective Tool to Probe Structure, Energetics and Fragmentation Mechanisms of Protonated Peptides
journal, April 1996

Dongré, Ashok R.; Somogyi, Árpád; Wysocki, Vicki H.
Journal of Mass Spectrometry, Vol. 31, Issue 4, p. 339-350
URL: 10.1002/(SICI)1096-9888(199604)31:4<339::AID-JMS322>3.0.CO;2-L

Similar Records in DOE Patents and OSTI.GOV collections:

Focused analyte spray emission apparatus and process for mass spectrometric analysis

Patent Roach, Patrick J [Kennewick, WA]; Laskin, Julia [Richland, WA]; Laskin, Alexander [Richland, WA]

An apparatus and process are disclosed that deliver an analyte deposited on a substrate to a mass spectrometer that provides for trace analysis of complex organic analytes. Analytes are probed using a small droplet of solvent that is formed at the junction between two capillaries. A supply capillary maintains the droplet of solvent on the substrate; a collection capillary collects analyte desorbed from the surface and emits analyte ions as a focused spray to the inlet of a mass spectrometer for analysis. The invention enables efficient separation of desorption and ionization events, providing enhanced control over transport and ionization ofmore » the analyte. « less
Full Text Available
Apparatus and method to control atmospheric water vapor composition and concentration during dynamic cooling of biological tissues in conjunction with laser irradiations

Patent Nelson, J Stuart [Laguna Niguel, CA]; Anvari, Bahman [Houston, TX]; Tanenbaum, B Samuel [Irvine, CA]; ...

Cryogen spray cooling of skin surface with millisecond cryogen spurts is an effective method for establishing a controlled temperature distribution in tissue and protecting the epidermis from nonspecific thermal injury during laser mediated dermatological procedures. Control of humidity level, spraying distance and cryogen boiling point is material to the resulting surface temperature. Decreasing the ambient humidity level results in less ice formation on the skin surface without altering the surface temperature during the cryogen spurt. For a particular delivery nozzle, increasing the spraying distance to 85 millimeters lowers the surface temperature. The methodology comprises establishing a controlled humidity level inmore » « less
Full Text Available
Method and apparatus of surface-incident, plasmon-enhanced multiple quantum well modulators and optical coupling thereon

Patent Liu, Jifeng; Wang, Xiaoxin; Hu, Juejun; ...

An optical interconnect system has first and second waveguides each with wedge-shaped cross-section at a first end, disposed over an optical modulator. The optical modulator is a surface-plasmon multi quantum well (SP-MQW) modulator, the first waveguide an input waveguide and the second waveguide configured an output waveguide. In embodiments the SP-MQW modulator has multiple semiconductor layers disposed atop a lower metal layer between 10 and 300 nanometers thick and configured such that incident light is reflected at the lower metal layer unless a voltage is applied to the semiconductor layers, when incident light is coupled into a surface plasmon modemore » in the lower metal layer. « less
Full Text Available
High resolution mass spectrometry method and system for analysis of whole proteins and other large molecules

Patent Reilly, Peter T. A. [Knoxville, TN]; Harris, William A [Naperville, IL]

A matrix assisted laser desorption/ionization (MALDI) method and related system for analyzing high molecular weight analytes includes the steps of providing at least one matrix-containing particle inside an ion trap, wherein at least one high molecular weight analyte molecule is provided within the matrix-containing particle, and MALDI on the high molecular weight particle while within the ion trap. A laser power used for ionization is sufficient to completely vaporize the particle and form at least one high molecular weight analyte ion, but is low enough to avoid fragmenting the high molecular weight analyte ion. The high molecular weight analyte ionmore » « less
Full Text Available
Method and apparatus for enhanced evanescent fluorescence and color filtering using a high refractive index thin film coating

Patent Kao, Hung Pin [2124 Promontory Cir., San Ramon, CA 94583]; Schoeniger, Joseph [126 Echo Ave., Oakland, CA 94611]; Yang, Nancy [72 Bacon Ct., Lafayette, CA 94549]

A technique for increasing the excitation and collection of evanescent fluorescence radiation emanating from a fiber optic sensor having a high refractive index (n.sub.r), dielectric thin film coating has been disclosed and described. The invention comprises a clad optical fiber core whose cladding is removed on a distal end, the distal end coated with a thin, non-porous, titanium dioxide sol-gel coating. It has been shown that such a fiber will exhibit increased fluorescence coupling due in part by 1) increasing the intensity of the evanescent field at the fiber core surface by a constructive interference effect on the propagating light,more » « less
Full Text Available

Similar Records

Title: Method and apparatus for enhanced sequencing of complex molecules using surface-induced dissociation in conjunction with mass spectrometric analysis

Abstract

Citation Formats

Proposal for an analytical form of the collisional energy deposition probability journal, February 1987

Intra-ionic interactions in electrosprayed peptide ions journal, March 1997

Dissociative and Reactive Hyperthermal Ion−Surface Collisions with Langmuir−Blodgett Films Terminated by CF 3 (CH 2 ) n −, n -Perfluoroalkyl, or n -Alkyl Groups journal, November 1999

Matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry with pulsed in-source collision gas and in-source ion accumulation journal, January 2000

A High-performance Modular Data System for Fourier Transform Ion Cyclotron Resonance Mass Spectrometry journal, November 1996

Shattering of Peptide Ions on Self-Assembled Monolayer Surfaces journal, February 2003

Dynamics of Energy Transfer in Peptide−Surface Collisions journal, February 2002

Collisional activation of peptide ions in FT-ICR mass spectrometry journal, January 2003

High pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry for minimization of ganglioside fragmentation journal, April 2002

A novel ion funnel for focusing ions at elevated pressure using electrospray ionization mass spectrometry journal, October 1997

Low energy collision induced dissociation: phase-shifting excitation control of ion kinetic energy in ion cyclotron resonance spectrometry journal, September 1992

Dissociative scattering of polyatomic ions from a liquid surface: CF3+ on a perfluoropolyether film journal, December 1997

Surface-Induced Dissociation of Multiply-Protonated Proteins journal, March 1995

Surface impact induced shattering of C6. Detection of small Cm fragments by negative surface ionization journal, August 1996

Preferential Fragmentation of Protonated Gas-Phase Peptide Ions Adjacent to Acidic Amino Acid Residues journal, May 1995

Reactions of ions with organic surfaces journal, November 1994

“Linearizing” an ion cyclotron resonance cell journal, December 2002

Identification of the facile gas-phase cleavage of the Asp-Pro and Asp-Xxx peptide bonds in matrix-assisted laser desorption time-of-flight mass spectrometry journal, November 1993

Surface-Induced Dissociation in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: Instrument Design and Evaluation journal, July 2002

A high pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry ion source for thermal stabilization of labile biomolecules journal, January 2001

Energy transfer in collisions of peptide ions with surfaces journal, August 2003

Surface-induced Dissociation: An Effective Tool to Probe Structure, Energetics and Fragmentation Mechanisms of Protonated Peptides journal, April 1996

Proposal for an analytical form of the collisional energy deposition probability
journal, February 1987

Intra-ionic interactions in electrosprayed peptide ions
journal, March 1997

Dissociative and Reactive Hyperthermal Ion−Surface Collisions with Langmuir−Blodgett Films Terminated by CF ₃ (CH ₂ ) _n −, n -Perfluoroalkyl, or n -Alkyl Groups
journal, November 1999

Matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry with pulsed in-source collision gas and in-source ion accumulation
journal, January 2000

A High-performance Modular Data System for Fourier Transform Ion Cyclotron Resonance Mass Spectrometry
journal, November 1996

Shattering of Peptide Ions on Self-Assembled Monolayer Surfaces
journal, February 2003

Dynamics of Energy Transfer in Peptide−Surface Collisions
journal, February 2002

Collisional activation of peptide ions in FT-ICR mass spectrometry
journal, January 2003

High pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry for minimization of ganglioside fragmentation
journal, April 2002

A novel ion funnel for focusing ions at elevated pressure using electrospray ionization mass spectrometry
journal, October 1997

Low energy collision induced dissociation: phase-shifting excitation control of ion kinetic energy in ion cyclotron resonance spectrometry
journal, September 1992

Dissociative scattering of polyatomic ions from a liquid surface: CF3+ on a perfluoropolyether film
journal, December 1997

Surface-Induced Dissociation of Multiply-Protonated Proteins
journal, March 1995

Surface impact induced shattering of C6. Detection of small Cm fragments by negative surface ionization
journal, August 1996

Preferential Fragmentation of Protonated Gas-Phase Peptide Ions Adjacent to Acidic Amino Acid Residues
journal, May 1995

Reactions of ions with organic surfaces
journal, November 1994

“Linearizing” an ion cyclotron resonance cell
journal, December 2002

Identification of the facile gas-phase cleavage of the Asp-Pro and Asp-Xxx peptide bonds in matrix-assisted laser desorption time-of-flight mass spectrometry
journal, November 1993

Surface-Induced Dissociation in a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: Instrument Design and Evaluation
journal, July 2002

A high pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry ion source for thermal stabilization of labile biomolecules
journal, January 2001

Energy transfer in collisions of peptide ions with surfaces
journal, August 2003

Surface-induced Dissociation: An Effective Tool to Probe Structure, Energetics and Fragmentation Mechanisms of Protonated Peptides
journal, April 1996