Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis

Pines, Alexander; Budinger, Thomas; Navon, Gil; Song, Yi-Qiao; Appelt, Stephan; Bifone, Angelo; Taylor, Rebecca; Goodson, Boyd; Seydoux, Roberto; Room, Toomas; Pietrass, Tanja

Title: Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis

Abstract

The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.

Inventors:

Pines, Alexander ^[1]; Budinger, Thomas ^[1]; Navon, Gil ^[2]; Song, Yi-Qiao ^[1]; Appelt, Stephan ^[3]; Bifone, Angelo ^[4]; Taylor, Rebecca ^[1]; Goodson, Boyd ^[1]; Seydoux, Roberto ^[1]; Room, Toomas ^[5]; Pietrass, Tanja ^[6]

Berkeley, CA
Ramat Gan, IL
Waiblingen, DE
Rome, IT
Albany, CA
Socorro, NM

Issue Date:: Tue Jun 10 00:00:00 EDT 2008

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 983068

Patent Number(s):: 7385395

Application Number:: 10/940,297

Assignee:: University of California

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K49/1815 - {compo-inhalant, e.g. breath tests}

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/282 - {Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent}
G01R33/5601 - {involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent}
G01R33/62 - using double resonance

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/24 - Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

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DOE Contract Number:: AC03-76SF00098

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

Citation Formats


                    Pines, Alexander, Budinger, Thomas, Navon, Gil, Song, Yi-Qiao, Appelt, Stephan, Bifone, Angelo, Taylor, Rebecca, Goodson, Boyd, Seydoux, Roberto, Room, Toomas, and Pietrass, Tanja. Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis.  United States: N. p., 2008. 
        Web.

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                    Pines, Alexander, Budinger, Thomas, Navon, Gil, Song, Yi-Qiao, Appelt, Stephan, Bifone, Angelo, Taylor, Rebecca, Goodson, Boyd, Seydoux, Roberto, Room, Toomas, & Pietrass, Tanja. Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis.  United States.

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                    Pines, Alexander, Budinger, Thomas, Navon, Gil, Song, Yi-Qiao, Appelt, Stephan, Bifone, Angelo, Taylor, Rebecca, Goodson, Boyd, Seydoux, Roberto, Room, Toomas, and Pietrass, Tanja. Tue .  
        "Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis".  United States.  https://www.osti.gov/servlets/purl/983068.

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@article{osti_983068,

  title        = {Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis},

  author       = {Pines, Alexander and Budinger, Thomas and Navon, Gil and Song, Yi-Qiao and Appelt, Stephan and Bifone, Angelo and Taylor, Rebecca and Goodson, Boyd and Seydoux, Roberto and Room, Toomas and Pietrass, Tanja},

  abstractNote = {The present invention relates generally to nuclear magnetic resonance (NMR) techniques for both spectroscopy and imaging. More particularly, the present invention relates to methods in which hyperpolarized noble gases (e.g., Xe and He) are used to enhance and improve NMR and MRI. Additionally, the hyperpolarized gas solutions of the invention are useful both in vitro and in vivo to study the dynamics or structure of a system. When used with biological systems, either in vivo or in vitro, it is within the scope of the invention to target the hyperpolarized gas and deliver it to specific regions within the system.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jun 10 00:00:00 EDT 2008},

  month        = {Tue Jun 10 00:00:00 EDT 2008}

}

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Hall, Jason A.; Gehring, Kalle; Nikaido, Hiroshi
Journal of Biological Chemistry, Vol. 272, Issue 28
https://doi.org/10.1074/jbc.272.28.17605

Multi-planar image formation using NMR spin echoes
journal, February 1977

Mansfield, P.
Journal of Physics C: Solid State Physics, Vol. 10, Issue 3
https://doi.org/10.1088/0022-3719/10/3/004

Novel NMR apparatus for investigating an external sample
journal, May 1992

Kleinberg, R. L.; Sezginer, A.; Griffin, D. D.
Journal of Magnetic Resonance (1969), Vol. 97, Issue 3
https://doi.org/10.1016/0022-2364(92)90028-6

Thermophilic Aminopeptidases from Bacillus Stearothermophilus. i. Isolation, Specificity, and General Properties of the Thermostable Aminopeptidase i *
journal, December 1969

Roncari, G.; Zuber, H.
International Journal of Protein Research, Vol. 1, Issue 1-4
https://doi.org/10.1111/j.1399-3011.1969.tb01625.x

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Title: Apparatus for preparing a solution of a hyperpolarized noble gas for NMR and MRI analysis

Abstract

Citation Formats

Optical Pumping journal, August 1963

Two new abnormal pathways in the para-Claisen rearrangement of 2(allyloxy)- and 2-(crotyloxy)-3-hydroxybenzaldehyde journal, March 1991

Enhancement of Solution NMR and MRI with Laser-Polarized Xenon journal, March 1996

Discovering High-Affinity Ligands for Proteins: SAR by NMR journal, November 1996

The NMR-mouse: construction, excitation, and applications journal, June 1998

Spin-polarized xenon-129 NMR study of a polymer surface journal, February 1993

Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin journal, August 1997

129 Xe NMR Spectroscopy of Deuterium-Labeled Cryptophane-A Xenon Complexes: Investigation of Host−Guest Complexation Dynamics journal, February 2000

Polarization of Nuclei in Metals journal, October 1953

Low field magnetic resonance images of polarized noble gases obtained with a dc superconducting quantum interference device journal, April 1998

Nuclear Magnetic Resonance Spectroscopy in the Earth Sciences: Structure and Dynamics journal, July 1989

Spin-lattice relaxation of laser-polarized xenon in human blood journal, March 1999

Isolation and characterization of a thermostable aminopeptidase(aminopeptidase T) from Thermus aquaticus YT-1, an extremely thermophilic bacterium. journal, January 1988

In SituNMR Analysis of Fluids Contained in Sedimentary Rock journal, August 1998

Approach to High-Resolution ex Situ NMR Spectroscopy journal, July 2001

Voltage-sensitive magnetic gels as magnetic resonance monitoring agents journal, May 1993

NMR of laser-polarized xenon in human blood journal, November 1996

Evidence of nonspecific surface interactions between laser-polarized xenon and myoglobin in solution journal, August 2000

Fluorescence polarization — a new tool for cell and molecular biology journal, May 1995

Selective Enhancement of NMR Signals forα-Cyclodextrin with Laser-Polarized Xenon journal, November 1997

Temperature-dependent molecular motions of cholesterol esters: a carbon-13 nuclear magnetic resonance study journal, December 1982

Binding of Xenon to Sperm Whale Myoglobin journal, July 1965

Nuclear magnetic resonance studies of xenon-129 with myoglobin and hemoglobin journal, December 1982

Hyperpolarized129Xe NMR as a probe for blood oxygenation journal, April 2000

Exploring Surfaces and Cavities in Lipoxygenase and Other Proteins by Hyperpolarized Xenon-129 NMR journal, September 1999

High-field NMR of adsorbed xenon polarized by laser pumping journal, February 1991

Introduction book, January 1971

Xenon NMR: chemical shifts of a general anesthetic in common solvents, proteins, and membranes. journal, August 1981

Spin Dynamics of Carr–Purcell–Meiboom–Gill-like Sequences in Grossly Inhomogeneous B0 and B1 Fields and Application to NMR Well Logging journal, March 2000

In vivo magnetic resonance vascular imaging using laser-polarized 3He microbubbles journal, September 1998

Study of Xenon Binding in Cryptophane-A Using Laser-Induced NMR Polarization Enhancement journal, April 1999

Measurement of high-resolution NMR spectra in an inhomogeneous magnetic field journal, November 1987

Biospecific interaction analysis using biosensor technology journal, January 1993

Nuclear magnetic relaxation of Xenon-129 dissolved in organic solvents journal, December 1991

Magnetization transfer from laser-polarized xenon to protons located in the hydrophobic cavity of the wheat nonspecific lipid transfer protein journal, April 2001

High-resolution NMR spectra in inhomogeneous magnetic fields: application of total spin coherence transfer echoes journal, June 1981

High-field cross polarization NMR from laser-polarized xenon to a polymer surface journal, September 1993

Some Developments in Nuclear Magnetic Resonance of Solids journal, October 1989

Relaxation Processes in a System of Two Spins journal, July 1955

Spin-Polarized 129Xe Gas Imaging of Materials journal, July 1995

Spin-exchange optical pumping of noble-gas nuclei journal, April 1997

MR Imaging with Hyperpolarized3He Gas journal, February 1995

Maltose Transport in Escherichia coli K12. A Comparison of Transport Kinetics in Wild-Type and lamba-Resistant Mutants with the Dissociation Constants of the Maltose-Binding Protein as Measured by Fluorescence Quenching journal, May 1976

Production of Thermostable Alkaline Proteases by Thermophilic Streptomyces journal, January 1969

Polarization of the nuclear spins of noble-gas atoms by spin exchange with optically pumped alkali-metal atoms journal, June 1984

NMR of optically pumped xenon thin films journal, April 1992

In vivo visualization of gene expression using magnetic resonance imaging journal, March 2000

patent,

Nuclear Magnetic Resonance Spectra from a Crystal rotated at High Speed journal, December 1958

Diffusion Measurements with the Aid of Nutation Spin Echoes Appearing after Two Inhomogeneous Radiofrequency Pulses in Inhomogeneous Magnetic Fields journal, February 2001

Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis journal, November 1992

129 Xe and 1 H NMR Study of the Reversible Trapping of Xenon by Cryptophane-A in Organic Solution journal, February 1998

Detection of a Conformational Change in Maltose Binding Protein by 129 Xe NMR Spectroscopy journal, September 2001

Nuclear magnetic relaxation of the 129 Xe and 131 Xe isotopes of xenon gas dissolved in isotropic and anisotropic liquids journal, July 1990

Imaging with intermolecular multiple-quantum coherences in solution nuclear magnetic resonance journal, February 1995

Mapping of metabolites in whole animals by 31P NMR using surface coils journal, January 1980

Biological magnetic resonance imaging using laser-polarized 129Xe journal, July 1994

Multiple echoes initiated by a single radio frequency pulse in NMR journal, November 1998

Structural origins of high-affinity biotin binding to streptavidin journal, January 1989

Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme journal, September 2000

Hyperpolarized Gases Set NMR World Spinning: Chemical applications of laser polarization include improved NMR sensitivity journal, December 1996

Possibilities for high-resolution nuclear magnetic resonance spectra of crystals journal, January 1962

129 Xe NMR Spectroscopy of Metal Carbonyl Clusters and Metal Clusters in Zeolite NaY journal, August 1999

Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides: DETERMINANTS OF SPECIFICITY AND UTILITY IN ASSAYS OF RECEPTOR FUNCTION journal, April 2000

Evidence of xenon transport through the gramicidin channel: a 129Xe-NMR study journal, July 1994

Cross polarization from laser-polarized solid xenon to 13CO2 by low-field thermal mixing journal, April 1993

High-resolution NMR in inhomogeneous fields journal, October 1997

Spin transfer between laser-polarized 129Xe nuclei and surface protons journal, December 1993

Conformational Changes of Three Periplasmic Receptors for Bacterial Chemotaxis and Transport: The Maltose-, Glucose/Galactose- and Ribose-binding Proteins. journal, November 1996

Cyclotriveratrylenes and cryptophanes journal, January 1987

Synthesis and exciton optical activity of D3-cryptophanes journal, October 1987

Intracellular calcium measurements by 19F NMR of fluorine-labeled chelators. journal, December 1983

The Nutation Spin Echo and Its Use for Localized NMR journal, September 2000

Surface Relaxation Mechanisms of Laser-Polarized 129 Xe journal, June 1995

Cavities in proteins: structure of a metmyoglobin xenon complex solved to 1.9 .ANG. journal, June 1984

An NMR study of ligand binding by maltodextrin binding protein journal, May 1998

[3] Applications of avidin-biotin technology: Literature survey book, January 1990

Optical Pumping
journal, August 1963

Two new abnormal pathways in the para-Claisen rearrangement of 2(allyloxy)- and 2-(crotyloxy)-3-hydroxybenzaldehyde
journal, March 1991

Enhancement of Solution NMR and MRI with Laser-Polarized Xenon
journal, March 1996

Discovering High-Affinity Ligands for Proteins: SAR by NMR
journal, November 1996

The NMR-mouse: construction, excitation, and applications
journal, June 1998

Spin-polarized xenon-129 NMR study of a polymer surface
journal, February 1993

Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
journal, August 1997

¹²⁹ Xe NMR Spectroscopy of Deuterium-Labeled Cryptophane-A Xenon Complexes: Investigation of Host−Guest Complexation Dynamics
journal, February 2000

Polarization of Nuclei in Metals
journal, October 1953

Low field magnetic resonance images of polarized noble gases obtained with a dc superconducting quantum interference device
journal, April 1998

Nuclear Magnetic Resonance Spectroscopy in the Earth Sciences: Structure and Dynamics
journal, July 1989

Spin-lattice relaxation of laser-polarized xenon in human blood
journal, March 1999

Isolation and characterization of a thermostable aminopeptidase(aminopeptidase T) from Thermus aquaticus YT-1, an extremely thermophilic bacterium.
journal, January 1988

In SituNMR Analysis of Fluids Contained in Sedimentary Rock
journal, August 1998

Approach to High-Resolution ex Situ NMR Spectroscopy
journal, July 2001

Voltage-sensitive magnetic gels as magnetic resonance monitoring agents
journal, May 1993

NMR of laser-polarized xenon in human blood
journal, November 1996

Evidence of nonspecific surface interactions between laser-polarized xenon and myoglobin in solution
journal, August 2000

Fluorescence polarization — a new tool for cell and molecular biology
journal, May 1995

Selective Enhancement of NMR Signals forα-Cyclodextrin with Laser-Polarized Xenon
journal, November 1997

Temperature-dependent molecular motions of cholesterol esters: a carbon-13 nuclear magnetic resonance study
journal, December 1982

Binding of Xenon to Sperm Whale Myoglobin
journal, July 1965

Nuclear magnetic resonance studies of xenon-129 with myoglobin and hemoglobin
journal, December 1982

Hyperpolarized129Xe NMR as a probe for blood oxygenation
journal, April 2000

Exploring Surfaces and Cavities in Lipoxygenase and Other Proteins by Hyperpolarized Xenon-129 NMR
journal, September 1999

High-field NMR of adsorbed xenon polarized by laser pumping
journal, February 1991

Introduction
book, January 1971

Xenon NMR: chemical shifts of a general anesthetic in common solvents, proteins, and membranes.
journal, August 1981

Spin Dynamics of Carr–Purcell–Meiboom–Gill-like Sequences in Grossly Inhomogeneous B0 and B1 Fields and Application to NMR Well Logging
journal, March 2000

In vivo magnetic resonance vascular imaging using laser-polarized 3He microbubbles
journal, September 1998

Study of Xenon Binding in Cryptophane-A Using Laser-Induced NMR Polarization Enhancement
journal, April 1999

Measurement of high-resolution NMR spectra in an inhomogeneous magnetic field
journal, November 1987

Biospecific interaction analysis using biosensor technology
journal, January 1993

Nuclear magnetic relaxation of Xenon-129 dissolved in organic solvents
journal, December 1991

Magnetization transfer from laser-polarized xenon to protons located in the hydrophobic cavity of the wheat nonspecific lipid transfer protein
journal, April 2001

High-resolution NMR spectra in inhomogeneous magnetic fields: application of total spin coherence transfer echoes
journal, June 1981

High-field cross polarization NMR from laser-polarized xenon to a polymer surface
journal, September 1993

Some Developments in Nuclear Magnetic Resonance of Solids
journal, October 1989

Relaxation Processes in a System of Two Spins
journal, July 1955

Spin-Polarized 129Xe Gas Imaging of Materials
journal, July 1995

Spin-exchange optical pumping of noble-gas nuclei
journal, April 1997

MR Imaging with Hyperpolarized3He Gas
journal, February 1995

Maltose Transport in Escherichia coli K12. A Comparison of Transport Kinetics in Wild-Type and lamba-Resistant Mutants with the Dissociation Constants of the Maltose-Binding Protein as Measured by Fluorescence Quenching
journal, May 1976

Production of Thermostable Alkaline Proteases by Thermophilic Streptomyces
journal, January 1969

Polarization of the nuclear spins of noble-gas atoms by spin exchange with optically pumped alkali-metal atoms
journal, June 1984

NMR of optically pumped xenon thin films
journal, April 1992

In vivo visualization of gene expression using magnetic resonance imaging
journal, March 2000

Nuclear Magnetic Resonance Spectra from a Crystal rotated at High Speed
journal, December 1958

Diffusion Measurements with the Aid of Nutation Spin Echoes Appearing after Two Inhomogeneous Radiofrequency Pulses in Inhomogeneous Magnetic Fields
journal, February 2001

Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis
journal, November 1992

129 Xe and 1 H NMR Study of the Reversible Trapping of Xenon by Cryptophane-A in Organic Solution
journal, February 1998

Detection of a Conformational Change in Maltose Binding Protein by ¹²⁹ Xe NMR Spectroscopy
journal, September 2001

Nuclear magnetic relaxation of the 129 Xe and 131 Xe isotopes of xenon gas dissolved in isotropic and anisotropic liquids
journal, July 1990

Imaging with intermolecular multiple-quantum coherences in solution nuclear magnetic resonance
journal, February 1995

Mapping of metabolites in whole animals by 31P NMR using surface coils
journal, January 1980

Biological magnetic resonance imaging using laser-polarized 129Xe
journal, July 1994

Multiple echoes initiated by a single radio frequency pulse in NMR
journal, November 1998

Structural origins of high-affinity biotin binding to streptavidin
journal, January 1989

Size versus polarizability in protein-ligand interactions: binding of noble gases within engineered cavities in phage T4 lysozyme
journal, September 2000

Hyperpolarized Gases Set NMR World Spinning: Chemical applications of laser polarization include improved NMR sensitivity
journal, December 1996

Possibilities for high-resolution nuclear magnetic resonance spectra of crystals
journal, January 1962

¹²⁹ Xe NMR Spectroscopy of Metal Carbonyl Clusters and Metal Clusters in Zeolite NaY
journal, August 1999

Structure-Function Analysis of Protease-activated Receptor 4 Tethered Ligand Peptides: DETERMINANTS OF SPECIFICITY AND UTILITY IN ASSAYS OF RECEPTOR FUNCTION
journal, April 2000

Evidence of xenon transport through the gramicidin channel: a 129Xe-NMR study
journal, July 1994

Cross polarization from laser-polarized solid xenon to 13CO2 by low-field thermal mixing
journal, April 1993

High-resolution NMR in inhomogeneous fields
journal, October 1997

Spin transfer between laser-polarized 129Xe nuclei and surface protons
journal, December 1993

Conformational Changes of Three Periplasmic Receptors for Bacterial Chemotaxis and Transport: The Maltose-, Glucose/Galactose- and Ribose-binding Proteins.
journal, November 1996

Cyclotriveratrylenes and cryptophanes
journal, January 1987

Synthesis and exciton optical activity of D3-cryptophanes
journal, October 1987

Intracellular calcium measurements by 19F NMR of fluorine-labeled chelators.
journal, December 1983

The Nutation Spin Echo and Its Use for Localized NMR
journal, September 2000

Surface Relaxation Mechanisms of Laser-Polarized $^{129} Xe$
journal, June 1995

Cavities in proteins: structure of a metmyoglobin xenon complex solved to 1.9 .ANG.
journal, June 1984

An NMR study of ligand binding by maltodextrin binding protein
journal, May 1998

[3] Applications of avidin-biotin technology: Literature survey
book, January 1990

FLASH imaging. Rapid NMR imaging using low flip-angle pulses
journal, April 1986

Experimental Verification of the Overhauser Nuclear Polarization Effect
journal, May 1956

Chemistry: "Amplifying" the Fine Details of Molecular Structure Is a Gas
journal, March 1996

Measurement of 129Xe T1 in Blood to Explore the Feasibility of Hyperpolarized 129Xe MRI
journal, January 1995