Targeted polypeptide degradation
Abstract
This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.
- Inventors:
-
- Brookline, MA
- Issue Date:
- Research Org.:
- Harvard University
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 983006
- Patent Number(s):
- 7371539
- Application Number:
- 11/003,103
- Assignee:
- President and Fellows of Harvard College (Cambridge, MA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- FG02-87ER60565
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Church, George M, and Janse, Daniel M. Targeted polypeptide degradation. United States: N. p., 2008.
Web.
Church, George M, & Janse, Daniel M. Targeted polypeptide degradation. United States.
Church, George M, and Janse, Daniel M. Tue .
"Targeted polypeptide degradation". United States. https://www.osti.gov/servlets/purl/983006.
@article{osti_983006,
title = {Targeted polypeptide degradation},
author = {Church, George M and Janse, Daniel M},
abstractNote = {This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or activity of a polypeptide by targeting these polypeptides for degradation, as well as methods for targeting therapeutic polypeptides for degradation and/or activating therapeutic polypeptides by degradation are provided. The invention provides methods for identifying compounds that mediate proteasome localization and/or polypeptide degradation. The invention also provides research tools for the study of protein function.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 13 00:00:00 EDT 2008},
month = {Tue May 13 00:00:00 EDT 2008}
}
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