Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides
Abstract
A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): wherein A is an organic moiety, n is at least 1, and each X is independently selected from the group consisting of --NRCOCONu, --NHCOCR.sub.2 CR.sub.2 CONu, --NHCOCR.dbd.CRCONu, and --NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile, or a salt of the compound.
- Inventors:
-
- Germantown, MD
- Montgomery Village, MD
- Issue Date:
- Research Org.:
- Fidelity Systems, Inc. (Gaithersburg, MD)
- OSTI Identifier:
- 880175
- Patent Number(s):
- 6548251
- Application Number:
- 10/655804
- Assignee:
- Fidelity Systems, Inc. (Gaithersburg, MD)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- FG02-98ER82577
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Kozyavkin, Sergei A, Malykh, Andrei G, Polouchine, Nikolai N, and Slesarev, Alexei I. Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides. United States: N. p., 2003.
Web.
Kozyavkin, Sergei A, Malykh, Andrei G, Polouchine, Nikolai N, & Slesarev, Alexei I. Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides. United States.
Kozyavkin, Sergei A, Malykh, Andrei G, Polouchine, Nikolai N, and Slesarev, Alexei I. Tue .
"Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides". United States. https://www.osti.gov/servlets/purl/880175.
@article{osti_880175,
title = {Inhibition Of Molecular And Biological Processes Using Modified Oligonucleotides},
author = {Kozyavkin, Sergei A and Malykh, Andrei G and Polouchine, Nikolai N and Slesarev, Alexei I},
abstractNote = {A method of inhibiting at least one molecular process in a sample, comprising administering to the sample an oligonucleotide or polynucleotide containing at least one monomeric unit having formula (I): wherein A is an organic moiety, n is at least 1, and each X is independently selected from the group consisting of --NRCOCONu, --NHCOCR.sub.2 CR.sub.2 CONu, --NHCOCR.dbd.CRCONu, and --NHCOSSCONu, wherein each R independently represents H or a substituted or unsubstituted alkyl group, and Nu represents a nucleophile, or a salt of the compound.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Apr 15 00:00:00 EDT 2003},
month = {Tue Apr 15 00:00:00 EDT 2003}
}
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