Antithrombogenic Polymer Coating.
Abstract
An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A).sub.3 P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin.
- Inventors:
-
- San Ramon, CA
- Utica, OH
- Flint, MI
- Ann Arbor, MI
- Issue Date:
- OSTI Identifier:
- 879678
- Patent Number(s):
- 6509104
- Application Number:
- 09/730098
- Assignee:
- Michigan Biotechnology Institute (Lansing, MI)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- DOE Contract Number:
- XXE-9-29058-01
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Huang, Zhi Heng, McDonald, William F, Wright, Stacy C, and Taylor, Andrew C. Antithrombogenic Polymer Coating.. United States: N. p., 2003.
Web.
Huang, Zhi Heng, McDonald, William F, Wright, Stacy C, & Taylor, Andrew C. Antithrombogenic Polymer Coating.. United States.
Huang, Zhi Heng, McDonald, William F, Wright, Stacy C, and Taylor, Andrew C. Tue .
"Antithrombogenic Polymer Coating.". United States. https://www.osti.gov/servlets/purl/879678.
@article{osti_879678,
title = {Antithrombogenic Polymer Coating.},
author = {Huang, Zhi Heng and McDonald, William F and Wright, Stacy C and Taylor, Andrew C},
abstractNote = {An article having a non-thrombogenic surface and a process for making the article are disclosed. The article is formed by (i) coating a polymeric substrate with a crosslinked chemical combination of a polymer having at least two amino substituted side chains, a crosslinking agent containing at least two crosslinking functional groups which react with amino groups on the polymer, and a linking agent containing a first functional group which reacts with a third functional group of the crosslinking agent, and (ii) contacting the coating on the substrate with an antithrombogenic agent which covalently bonds to a second functional group of the linking agent. In one example embodiment, the polymer is a polyamide having amino substituted alkyl chains on one side of the polyamide backbone, the crosslinking agent is a phosphine having the general formula (A).sub.3 P wherein A is hydroxyalkyl, the linking agent is a polyhydrazide and the antithrombogenic agent is heparin.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 21 00:00:00 EST 2003},
month = {Tue Jan 21 00:00:00 EST 2003}
}
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