4-fluoroalkyl-3-halophenyl nortropanes
Abstract
A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes family are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high affinity and selectivity. The invention provides methods of synthesis which incorporate radioisotopic halogens at a last step which permit high radiochemical yield and maximum usable product life. The radiolabeled compounds of the invention are useful as imaging agents for visualizing the location and density of serotonin transporter by PET and SPECT imaging.
- Inventors:
-
- Atlanta, GA
- Indianapolis, IN
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- OSTI Identifier:
- 874483
- Patent Number(s):
- 6399042
- Application Number:
- 10/558916
- Assignee:
- Emory University (Atlanta, GA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- FG02-97ER62367
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 4-fluoroalkyl-3-halophenyl; nortropanes; series; compounds; family; described; diagnostic; therapeutic; agents; diseases; associated; serotonin; transporter; dysfunction; bind; protein; affinity; selectivity; provides; methods; synthesis; incorporate; radioisotopic; halogens; step; permit; radiochemical; yield; maximum; usable; product; life; radiolabeled; useful; imaging; visualizing; location; density; pet; provides methods; therapeutic agent; /424/999/
Citation Formats
Goodman, Mark M, and Chen, Ping. 4-fluoroalkyl-3-halophenyl nortropanes. United States: N. p., 2002.
Web.
Goodman, Mark M, & Chen, Ping. 4-fluoroalkyl-3-halophenyl nortropanes. United States.
Goodman, Mark M, and Chen, Ping. Tue .
"4-fluoroalkyl-3-halophenyl nortropanes". United States. https://www.osti.gov/servlets/purl/874483.
@article{osti_874483,
title = {4-fluoroalkyl-3-halophenyl nortropanes},
author = {Goodman, Mark M and Chen, Ping},
abstractNote = {A series of compounds in the 4-fluoroalkyl-3-halophenyl nortropanes family are described as diagnostic and therapeutic agents for diseases associated with serotonin transporter dysfunction. These compounds bind to serotonin transporter protein with high affinity and selectivity. The invention provides methods of synthesis which incorporate radioisotopic halogens at a last step which permit high radiochemical yield and maximum usable product life. The radiolabeled compounds of the invention are useful as imaging agents for visualizing the location and density of serotonin transporter by PET and SPECT imaging.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 2002},
month = {Tue Jan 01 00:00:00 EST 2002}
}
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