Fluoralkenyl nortropanes
Abstract
Provided are compounds of the following formula: ##STR1## wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopamine transporter with high affinity and selectivity and are thus useful as diagnostic and therapeutic agents for diseases associated with dopamine transporter dysfunction. The radiolabeled compounds are useful as imaging agents for visualizing the location and density of dopamine transporter by PET imaging.
- Inventors:
-
- Atlanta, GA
- Indianapolis, IN
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- OSTI Identifier:
- 874224
- Patent Number(s):
- 6344179
- Application Number:
- 09/553795
- Assignee:
- Emory University (Atlanta, GA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- FG02-97ER62367
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- fluoralkenyl; nortropanes; provided; compounds; following; formula; str1; c2-c6; mono-; multi-unsaturated; hydrocarbon; ethylene; acetylene; allene; 18; 19; halogen; bind; dopamine; transporter; affinity; selectivity; useful; diagnostic; therapeutic; agents; diseases; associated; dysfunction; radiolabeled; imaging; visualizing; location; density; pet; pet imaging; saturated hydrocarbon; unsaturated hydrocarbon; /424/999/
Citation Formats
Goodman, Mark M, and Chen, Ping. Fluoralkenyl nortropanes. United States: N. p., 2002.
Web.
Goodman, Mark M, & Chen, Ping. Fluoralkenyl nortropanes. United States.
Goodman, Mark M, and Chen, Ping. Tue .
"Fluoralkenyl nortropanes". United States. https://www.osti.gov/servlets/purl/874224.
@article{osti_874224,
title = {Fluoralkenyl nortropanes},
author = {Goodman, Mark M and Chen, Ping},
abstractNote = {Provided are compounds of the following formula: ##STR1## wherein R is C2-C6 mono- or multi-unsaturated hydrocarbon having one or more ethylene, acetylene or allene groups, A is 18 or 19, and X is H or halogen. The compounds of the invention bind to dopamine transporter with high affinity and selectivity and are thus useful as diagnostic and therapeutic agents for diseases associated with dopamine transporter dysfunction. The radiolabeled compounds are useful as imaging agents for visualizing the location and density of dopamine transporter by PET imaging.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 01 00:00:00 EST 2002},
month = {Tue Jan 01 00:00:00 EST 2002}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
The Dopamine Transporter Is Absent in Parkinsonian Putamen and Reduced in the Caudate Nucleus
journal, January 1991
- Niznik, Hyman B.; Fogel, Evan F.; Fassos, Frank F.
- Journal of Neurochemistry, Vol. 56, Issue 1
IPT: A novel iodinated ligand for the CNS dopamine transporter
journal, August 1995
- Kung, Mei-Ping; Essman, William D.; Frederick, Dana
- Synapse, Vol. 20, Issue 4
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
journal, February 1996
- Giros, Bruno; Jaber, Mohamed; Jones, Sara R.
- Nature, Vol. 379, Issue 6566
Synthesis and Characterization of Radioiodinated N-(3-Iodopropen-1-yl)-2.beta.-carbomethoxy-3.beta.-(4-chlorophenyl)tropanes: Potential Dopamine Reuptake Site Imaging Agents
journal, May 1994
- Goodman, Mark M.; Kung, Mei-Ping; Kabalka, George W.
- Journal of Medicinal Chemistry, Vol. 37, Issue 10