Detection of biological molecules using chemical amplification and optical sensors
Abstract
Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal. Specifically, the analyte transducer immobilized in a polymeric matrix can be a boronic acid moiety.
- Inventors:
-
- Valencia, CA
- Los Angeles, CA
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- OSTI Identifier:
- 874129
- Patent Number(s):
- 6319540
- Assignee:
- MiniMed Inc. (Northridge, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- W-7405-ENG-48
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- detection; biological; molecules; chemical; amplification; optical; sensors; methods; provided; determination; concentration; levels; polyhydroxylated; compounds; glucose; utilize; analyte; transducer; immobilized; polymeric; matrix; implantable; biocompatible; interrogation; produces; signal; capable; external; patient; quantitation; achieved; measurement; emitted; specifically; boronic; acid; moiety; optical sensor; biological molecules; methods utilize; /427/428/
Citation Formats
Van Antwerp, William Peter, and Mastrototaro, John Joseph. Detection of biological molecules using chemical amplification and optical sensors. United States: N. p., 2001.
Web.
Van Antwerp, William Peter, & Mastrototaro, John Joseph. Detection of biological molecules using chemical amplification and optical sensors. United States.
Van Antwerp, William Peter, and Mastrototaro, John Joseph. Mon .
"Detection of biological molecules using chemical amplification and optical sensors". United States. https://www.osti.gov/servlets/purl/874129.
@article{osti_874129,
title = {Detection of biological molecules using chemical amplification and optical sensors},
author = {Van Antwerp, William Peter and Mastrototaro, John Joseph},
abstractNote = {Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal. Specifically, the analyte transducer immobilized in a polymeric matrix can be a boronic acid moiety.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2001},
month = {Mon Jan 01 00:00:00 EST 2001}
}
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