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Title: Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use

Abstract

Radiopharmaceutical compositions including .sup.117m Sn labeled stannic (Sn.sup.4+) chelates are provided. The chelates are preferably polyhydroxycarboxylate, such as oxalates, tartrates, citrates, malonates, gluconates, glucoheptonates and the like. Methods of making .sup.117m Sn-labeled (Sn.sup.4+) polyhydroxycarboxylic chelates are also provided. The foregoing pharmaceutical compositions can be used in methods of preparing bone for scintigraphical analysis, for radiopharmaceutical skeletal imaging, treatment of pain resulting from metastatic bone involvement, treatment of primary bone cancer, treatment of cancer resulting from metastatic spread to bone from other primary cancers, treatment of pain resulting from rheumatoid arthritis, treatment of bone/joint disorders and to monitor radioactively the skeletal system.

Inventors:
 [1];  [2]
  1. Setauket, NY
  2. Middle Island, NY
Issue Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
OSTI Identifier:
873731
Patent Number(s):
6231832
Assignee:
Brookhaven Science Associates (Upton, NY)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
radiopharmaceutical; stannic; sn-117m; chelate; compositions; methods; including; 117m; labeled; chelates; provided; preferably; polyhydroxycarboxylate; oxalates; tartrates; citrates; malonates; gluconates; glucoheptonates; sn-labeled; polyhydroxycarboxylic; foregoing; pharmaceutical; preparing; bone; scintigraphical; analysis; skeletal; imaging; treatment; pain; resulting; metastatic; involvement; primary; cancer; spread; cancers; rheumatoid; arthritis; joint; disorders; monitor; radioactively; compositions including; pharmaceutical compositions; radiopharmaceutical composition; pharmaceutical composition; rheumatoid arthritis; sn-117m chelate; bone cancer; /424/999/

Citation Formats

Srivastava, Suresh C, and Meinken, George E. Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use. United States: N. p., 2001. Web.
Srivastava, Suresh C, & Meinken, George E. Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use. United States.
Srivastava, Suresh C, and Meinken, George E. Mon . "Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use". United States. https://www.osti.gov/servlets/purl/873731.
@article{osti_873731,
title = {Radiopharmaceutical stannic Sn-117m chelate compositions and methods of use},
author = {Srivastava, Suresh C and Meinken, George E},
abstractNote = {Radiopharmaceutical compositions including .sup.117m Sn labeled stannic (Sn.sup.4+) chelates are provided. The chelates are preferably polyhydroxycarboxylate, such as oxalates, tartrates, citrates, malonates, gluconates, glucoheptonates and the like. Methods of making .sup.117m Sn-labeled (Sn.sup.4+) polyhydroxycarboxylic chelates are also provided. The foregoing pharmaceutical compositions can be used in methods of preparing bone for scintigraphical analysis, for radiopharmaceutical skeletal imaging, treatment of pain resulting from metastatic bone involvement, treatment of primary bone cancer, treatment of cancer resulting from metastatic spread to bone from other primary cancers, treatment of pain resulting from rheumatoid arthritis, treatment of bone/joint disorders and to monitor radioactively the skeletal system.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2001},
month = {Mon Jan 01 00:00:00 EST 2001}
}

Works referenced in this record:

Biodistribution of Sn-117m(4+)DTPA for palliative therapy of painful osseous metastases.
journal, January 1993


Tin-117m: Production, chemistry and evaluation as a bone-scanning agent
journal, June 1973


The development and in-vivo behavior of tin containing radiopharmaceuticals—I. Chemistry, preparation, and biodistribution in small animals
journal, January 1985