Microfluidic circuit designs for performing fluidic manipulations that reduce the number of pumping sources and fluid reservoirs
Abstract
A microfabricated device and method for proportioning and mixing biological or chemical materials by pressure- or vacuum-driven flow is disclosed. The microfabricated device mixes a plurality of materials in volumetric proportions controlled by the flow resistances of tributary reagent channels through which the materials are transported. The microchip includes two or more tributary reagent channels combining at one or more junctions to form one or more mixing channels. By varying the geometries of the channels (length, cross section, etc.), a plurality of reagent materials can be mixed at a junction such that the proportions of the reagent materials in the mixing channel depend on a ratio of the channel geometries and material properties. Such an approach facilitates flow division on the microchip without relying on techniques external to the microchip. Microchannel designs that provide the necessary flow division to accomplish valving operations using a minimum of pressure or vacuum sources are also described. In addition, microchannel designs that accomplish fluidic operation utilizing a minimal number of fluidic reservoirs are disclosed.
- Inventors:
-
- Knoxville, TN
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 873655
- Patent Number(s):
- 6213151
- Application Number:
- 09/557,435
- Assignee:
- UT-Battelle, LLC (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC05-00OR22725
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- microfluidic; circuit; designs; performing; fluidic; manipulations; reduce; pumping; sources; fluid; reservoirs; microfabricated; device; method; proportioning; mixing; biological; chemical; materials; pressure-; vacuum-driven; flow; disclosed; mixes; plurality; volumetric; proportions; controlled; resistances; tributary; reagent; channels; transported; microchip; combining; junctions; form; varying; geometries; length; section; etc; mixed; junction; channel; depend; ratio; material; properties; approach; facilitates; division; relying; techniques; external; microchannel; provide; accomplish; valving; operations; minimum; pressure; vacuum; described; addition; operation; utilizing; minimal; microfabricated device; material properties; vacuum source; fluid reservoir; pumping source; chemical materials; chemical material; circuit designs; microfluidic circuit; flow resistance; fluid reservoirs; fluidic manipulations; channel design; /137/
Citation Formats
Jacobson, Stephen C, and Ramsey, J Michael. Microfluidic circuit designs for performing fluidic manipulations that reduce the number of pumping sources and fluid reservoirs. United States: N. p., 2001.
Web.
Jacobson, Stephen C, & Ramsey, J Michael. Microfluidic circuit designs for performing fluidic manipulations that reduce the number of pumping sources and fluid reservoirs. United States.
Jacobson, Stephen C, and Ramsey, J Michael. Mon .
"Microfluidic circuit designs for performing fluidic manipulations that reduce the number of pumping sources and fluid reservoirs". United States. https://www.osti.gov/servlets/purl/873655.
@article{osti_873655,
title = {Microfluidic circuit designs for performing fluidic manipulations that reduce the number of pumping sources and fluid reservoirs},
author = {Jacobson, Stephen C and Ramsey, J Michael},
abstractNote = {A microfabricated device and method for proportioning and mixing biological or chemical materials by pressure- or vacuum-driven flow is disclosed. The microfabricated device mixes a plurality of materials in volumetric proportions controlled by the flow resistances of tributary reagent channels through which the materials are transported. The microchip includes two or more tributary reagent channels combining at one or more junctions to form one or more mixing channels. By varying the geometries of the channels (length, cross section, etc.), a plurality of reagent materials can be mixed at a junction such that the proportions of the reagent materials in the mixing channel depend on a ratio of the channel geometries and material properties. Such an approach facilitates flow division on the microchip without relying on techniques external to the microchip. Microchannel designs that provide the necessary flow division to accomplish valving operations using a minimum of pressure or vacuum sources are also described. In addition, microchannel designs that accomplish fluidic operation utilizing a minimal number of fluidic reservoirs are disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 2001},
month = {Mon Jan 01 00:00:00 EST 2001}
}