Treatment of addiction and addiction-related behavior

Dewey, Stephen L; Brodie, Jonathan D

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Title: Treatment of addiction and addiction-related behavior

Abstract

The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a primate suffering from substance addiction. The method includes administering to a primate an effective amount of a pharmaceutical composition including gamma vinylGABA. The present invention also provides a method of treatment of nicotine addiction by treating a patient with an effective amount of a composition including gamma vinylGABA.

Inventors:

Dewey, Stephen L ^[1]; Brodie, Jonathan D ^[2]; Ashby, Jr., Charles R. ^[3]

Manorville, NY
Cos Cob, CT
(Miller Place, NY)

Issue Date:: Sat Jan 01 00:00:00 EST 2000

Research Org.:: BROOKHAVEN SCIENCE ASSOC LLC

OSTI Identifier:: 872977

Patent Number(s):: 6057368

Assignee:: Brookhaven Science Associates LLC (Upton, NY)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/00 - Medicinal preparations containing organic active ingredients
A61K31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine {or methadone}
A61K31/16 - Amides, e.g. hydroxamic acids
A61K31/165 - having aromatic rings, e.g. colchicine, atenolol, progabide
A61K31/19 - Carboxylic acids, e.g. valproic acid
A61K31/195 - having an amino group
A61K31/197 - the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
A61K31/221 - with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
A61K31/35 - having six-membered rings with one oxygen as the only ring hetero atom
A61K31/4535 - containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen

Show less

DOE Contract Number:: AC02-98CH10886

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: treatment; addiction; addiction-related; behavior; provides; highly; efficient; method; treating; substance; changing; primate; suffering; administering; effective; amount; pharmaceutical; composition; including; gamma; vinylgaba; nicotine; patient; efficient method; effective amount; highly efficient; composition including; pharmaceutical composition; substance addiction; addiction-related behavior; /514/

Citation Formats


                    Dewey, Stephen L, Brodie, Jonathan D, and Ashby, Jr., Charles R. Treatment of addiction and addiction-related behavior.  United States: N. p., 2000. 
        Web.

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                    Dewey, Stephen L, Brodie, Jonathan D, & Ashby, Jr., Charles R. Treatment of addiction and addiction-related behavior.  United States.

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                    Dewey, Stephen L, Brodie, Jonathan D, and Ashby, Jr., Charles R. Sat .  
        "Treatment of addiction and addiction-related behavior".  United States.  https://www.osti.gov/servlets/purl/872977.

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@article{osti_872977,

  title        = {Treatment of addiction and addiction-related behavior},

  author       = {Dewey, Stephen L and Brodie, Jonathan D and Ashby, Jr., Charles R.},

  abstractNote = {The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a primate suffering from substance addiction. The method includes administering to a primate an effective amount of a pharmaceutical composition including gamma vinylGABA. The present invention also provides a method of treatment of nicotine addiction by treating a patient with an effective amount of a composition including gamma vinylGABA.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Sat Jan 01 00:00:00 EST 2000},

  month        = {Sat Jan 01 00:00:00 EST 2000}

}

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Works referenced in this record:

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GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography
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Similar Records

Title: Treatment of addiction and addiction-related behavior

Abstract

Citation Formats

Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure journal, June 1997

Conditioned place preference induced by Δ9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward journal, May 1995

Striatal binding of the PET ligand11C-raclopride is altered by drugs that modify synaptic dopamine levels journal, April 1993

Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects. journal, December 1993

Pharmacologic characterization of nicotine-induced conditioned place preference journal, February 1985

Vigabatrin: A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Potential in Epilepsy and Disorders of Motor Control journal, January 1991

Nicotine Dependence, Midbrain Dopamine Systems and Psychiatric Disorders journal, March 1995

Self-administration in rats allowed unlimited access to nicotine journal, October 1997

Infusion of Nicotine in the Ventral Tegmental Area or the Nucleus Accumbens of the Rat Differentially Affects Accumbal Dopamine Release journal, December 1994

Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice journal, June 1998

Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens journal, September 1989

Apparent absence of nicotine-induced conditioned place preference in rats journal, May 1987

Control of behavior by intravenous nicotine injections in human subjects journal, December 1983

Place Conditioning: A Simple and Effective Method for Assessing the Motivational Properties of Drugs book, January 1987

Presynaptic Nicotinic Modulation of Dopamine Release in the Three Ascending Pathways Studied by In Vivo Microdialysis: Comparison of Naive and Chronic Nicotine-Treated Rats journal, April 1997

Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area journal, January 1994

Imaging endogenous dopamine competition with [11C]raclopride in the human brain journal, April 1994

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs journal, July 1996

?-VINYL GABA (4-amino-hex-5-enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA-T: EFFECTS ON BRAIN GABA METABOLISM IN MICE journal, November 1977

On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones. journal, July 1988

Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis journal, June 1984

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. journal, July 1988

Basic aspects of GABA-transmission in alcoholism, with particular reference to GABA-transaminase journal, February 1997

Amphetamine and vigabatrin down regulate aromatic l-amino acid decarboxylase mRNA levels journal, January 1996

Cigarette smokers self-administer intravenous nicotine journal, November 1983

GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography journal, October 1992

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [ N - 11 C-Methyl]-(−)-Cocaine PET Studies in Human Subjects journal, September 1990

Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds journal, October 1997

Pharmacological treatment of tobacco dependence journal, May 1988

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats journal, December 1986

Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: Comparison with caudate-putamen journal, December 1990

A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation journal, October 1997

Activation of ventral tegmental GABAB receptors inhibits morphine-induced place preference in rats journal, October 1996

Baclofen Attenuates the Reinforcing Effects of Cocaine in Rats journal, October 1996

Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure
journal, June 1997

Conditioned place preference induced by Δ9-tetrahydrocannabinol: comparison with cocaine, morphine, and food reward
journal, May 1995

Striatal binding of the PET ligand11C-raclopride is altered by drugs that modify synaptic dopamine levels
journal, April 1993

Effects of central cholinergic blockade on striatal dopamine release measured with positron emission tomography in normal human subjects.
journal, December 1993

Pharmacologic characterization of nicotine-induced conditioned place preference
journal, February 1985

Vigabatrin: A Review of its Pharmacodynamic and Pharmacokinetic Properties, and Therapeutic Potential in Epilepsy and Disorders of Motor Control
journal, January 1991

Nicotine Dependence, Midbrain Dopamine Systems and Psychiatric Disorders
journal, March 1995

Self-administration in rats allowed unlimited access to nicotine
journal, October 1997

Infusion of Nicotine in the Ventral Tegmental Area or the Nucleus Accumbens of the Rat Differentially Affects Accumbal Dopamine Release
journal, December 1994

Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice
journal, June 1998

Lack of tolerance to nicotine-induced dopamine release in the nucleus accumbens
journal, September 1989

Apparent absence of nicotine-induced conditioned place preference in rats
journal, May 1987

Control of behavior by intravenous nicotine injections in human subjects
journal, December 1983

Place Conditioning: A Simple and Effective Method for Assessing the Motivational Properties of Drugs
book, January 1987

Presynaptic Nicotinic Modulation of Dopamine Release in the Three Ascending Pathways Studied by In Vivo Microdialysis: Comparison of Naive and Chronic Nicotine-Treated Rats
journal, April 1997

Systemic nicotine-induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area
journal, January 1994

Imaging endogenous dopamine competition with [11C]raclopride in the human brain
journal, April 1994

Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs
journal, July 1996

?-VINYL GABA (4-amino-hex-5-enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA-T: EFFECTS ON BRAIN GABA METABOLISM IN MICE
journal, November 1977

On the potassium conductance increase activated by GABAB and dopamine D2 receptors in rat substantia nigra neurones.
journal, July 1988

Presynaptic regulation of neurotransmitter release in the brain: Facts and hypothesis
journal, June 1984

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
journal, July 1988

Basic aspects of GABA-transmission in alcoholism, with particular reference to GABA-transaminase
journal, February 1997

Amphetamine and vigabatrin down regulate aromatic l-amino acid decarboxylase mRNA levels
journal, January 1996

Cigarette smokers self-administer intravenous nicotine
journal, November 1983

GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography
journal, October 1992

Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [ N - ¹¹ C-Methyl]-(−)-Cocaine PET Studies in Human Subjects
journal, September 1990

Gamma-vinyl GABA attenuates cocaine-induced lowering of brain stimulation reward thresholds
journal, October 1997

Pharmacological treatment of tobacco dependence
journal, May 1988

Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats
journal, December 1986

Acute administration of nicotine increases the in vivo extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid and ascorbic acid preferentially in the nucleus accumbens of the rat: Comparison with caudate-putamen
journal, December 1990

A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation
journal, October 1997

Activation of ventral tegmental GABAB receptors inhibits morphine-induced place preference in rats
journal, October 1996

Baclofen Attenuates the Reinforcing Effects of Cocaine in Rats
journal, October 1996