Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters
Abstract
A process of preparing an acid addition salt of delta-aminolevulinic acid comprising: dissolving a lower alkyl 5-bromolevulinate and an alkali metal diformylamide in an organic solvent selected from the group consisting of acetonitrile, methanol, tetrahydrofuran, 2-methyltetrahydrofuran and methylformate or mixtures thereof to form a suspension of an alkyl 5-(N,N-diformylamino) levulinate ester; and hydrolyzing said alkyl 5-(N,N-diformylamino) levulinate with an inorganic acid to form an acid addition salt of delta-amino levulinic acid.
- Inventors:
-
- Lakewood, CO
- Issue Date:
- Research Org.:
- Midwest Research Institute, Kansas City, MO (United States)
- OSTI Identifier:
- 872302
- Patent Number(s):
- 5907058
- Assignee:
- Midwest Research Institute (Kansas City, MO)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
- DOE Contract Number:
- AC36-83CH10093
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- synthesis; acid; addition; salt; delta-aminolevulinic; 5-bromo; levulinic; esters; process; preparing; comprising; dissolving; alkyl; 5-bromolevulinate; alkali; metal; diformylamide; organic; solvent; selected; consisting; acetonitrile; methanol; tetrahydrofuran; 2-methyltetrahydrofuran; methylformate; mixtures; form; suspension; 5-; n-diformylamino; levulinate; ester; hydrolyzing; inorganic; delta-amino; acid ester; organic solvent; alkali metal; inorganic acid; organic acid; acid esters; acid comprising; acid addition; levulinic acid; addition salt; solvent selected; delta-aminolevulinic acid; /999/
Citation Formats
Moens, Luc. Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters. United States: N. p., 1999.
Web.
Moens, Luc. Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters. United States.
Moens, Luc. Fri .
"Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters". United States. https://www.osti.gov/servlets/purl/872302.
@article{osti_872302,
title = {Synthesis of an acid addition salt of delta-aminolevulinic acid from 5-bromo levulinic acid esters},
author = {Moens, Luc},
abstractNote = {A process of preparing an acid addition salt of delta-aminolevulinic acid comprising: dissolving a lower alkyl 5-bromolevulinate and an alkali metal diformylamide in an organic solvent selected from the group consisting of acetonitrile, methanol, tetrahydrofuran, 2-methyltetrahydrofuran and methylformate or mixtures thereof to form a suspension of an alkyl 5-(N,N-diformylamino) levulinate ester; and hydrolyzing said alkyl 5-(N,N-diformylamino) levulinate with an inorganic acid to form an acid addition salt of delta-amino levulinic acid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1999},
month = {Fri Jan 01 00:00:00 EST 1999}
}
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