Method for protection against genotoxic mutagenesis
Abstract
A method and pharmaceutical for protecting against genotoxic damage in irradiated cells. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides.
- Inventors:
-
- Naperville, IL
- Issue Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- OSTI Identifier:
- 870278
- Patent Number(s):
- 5488042
- Assignee:
- Arch Development Corporation (Chicago, IL)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
- DOE Contract Number:
- W-31109-ENG-38
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- method; protection; genotoxic; mutagenesis; pharmaceutical; protecting; damage; irradiated; cells; reduction; mutations; hypoxanthine-guanine; phosphoribosyl; transferase; locus; accomplished; administering; effective; dose; compound; protected; sulfhydryl; metabolize; vivo; produce; free; disulfides; genotoxic mutagenesis; /514/
Citation Formats
Grdina, David J. Method for protection against genotoxic mutagenesis. United States: N. p., 1996.
Web.
Grdina, David J. Method for protection against genotoxic mutagenesis. United States.
Grdina, David J. Mon .
"Method for protection against genotoxic mutagenesis". United States. https://www.osti.gov/servlets/purl/870278.
@article{osti_870278,
title = {Method for protection against genotoxic mutagenesis},
author = {Grdina, David J},
abstractNote = {A method and pharmaceutical for protecting against genotoxic damage in irradiated cells. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound having protected sulfhydryl groups which metabolize in vivo to produce both free sulfhydryl groups and disulfides.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1996},
month = {Mon Jan 01 00:00:00 EST 1996}
}
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