Reliable noninvasive measurement of blood gases
Abstract
Methods and apparatus for, preferably, determining noninvasively and in vivo at least two of the five blood gas parameters (i.e., pH, PCO.sub.2, [HCO.sub.3.sup.- ], PO.sub.2, and O.sub.2 sat.) in a human. The non-invasive method includes the steps of: generating light at three or more different wavelengths in the range of 500 nm to 2500 nm; irradiating blood containing tissue; measuring the intensities of the wavelengths emerging from the blood containing tissue to obtain a set of at least three spectral intensities v. wavelengths; and determining the unknown values of at least two of pH, [HCO.sub.3.sup.- ], PCO.sub.2 and a measure of oxygen concentration. The determined values are within the physiological ranges observed in blood containing tissue. The method also includes the steps of providing calibration samples, determining if the spectral intensities v. wavelengths from the tissue represents an outlier, and determining if any of the calibration samples represents an outlier. The determination of the unknown values is performed by at least one multivariate algorithm using two or more variables and at least one calibration model. Preferably, there is a separate calibration for each blood gas parameter being determined. The method can be utilized in a pulse mode and can alsomore »
- Inventors:
-
- Albuquerque, NM
- Issue Date:
- Research Org.:
- Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
- OSTI Identifier:
- 869557
- Patent Number(s):
- 5355880
- Assignee:
- Sandia Corporation (Albuquerque, NM)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- DOE Contract Number:
- AC04-76
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- reliable; noninvasive; measurement; blood; gases; methods; apparatus; preferably; determining; noninvasively; vivo; five; gas; parameters; ph; pco; hco; sat; human; non-invasive; method; steps; generating; light; wavelengths; range; 500; nm; 2500; irradiating; containing; tissue; measuring; intensities; emerging; obtain; set; spectral; values; measure; oxygen; concentration; determined; physiological; ranges; observed; providing; calibration; samples; represents; outlier; determination; performed; multivariate; algorithm; variables; model; separate; parameter; utilized; pulse; mode; invasively; positioning; device; source; detector; electronics; microprocessor; memory; indicating; blood containing; containing tissue; oxygen concentration; positioning device; noninvasive measurement; multivariate algorithm; generating light; blood gas; reliable noninvasive; pulse mode; non-invasive method; determining noninvasively; determined values; gas parameters; five blood; calibration mode; blood gases; /600/128/
Citation Formats
Thomas, Edward V, Robinson, Mark R, Haaland, David M, and Alam, Mary K. Reliable noninvasive measurement of blood gases. United States: N. p., 1994.
Web.
Thomas, Edward V, Robinson, Mark R, Haaland, David M, & Alam, Mary K. Reliable noninvasive measurement of blood gases. United States.
Thomas, Edward V, Robinson, Mark R, Haaland, David M, and Alam, Mary K. Sat .
"Reliable noninvasive measurement of blood gases". United States. https://www.osti.gov/servlets/purl/869557.
@article{osti_869557,
title = {Reliable noninvasive measurement of blood gases},
author = {Thomas, Edward V and Robinson, Mark R and Haaland, David M and Alam, Mary K},
abstractNote = {Methods and apparatus for, preferably, determining noninvasively and in vivo at least two of the five blood gas parameters (i.e., pH, PCO.sub.2, [HCO.sub.3.sup.- ], PO.sub.2, and O.sub.2 sat.) in a human. The non-invasive method includes the steps of: generating light at three or more different wavelengths in the range of 500 nm to 2500 nm; irradiating blood containing tissue; measuring the intensities of the wavelengths emerging from the blood containing tissue to obtain a set of at least three spectral intensities v. wavelengths; and determining the unknown values of at least two of pH, [HCO.sub.3.sup.- ], PCO.sub.2 and a measure of oxygen concentration. The determined values are within the physiological ranges observed in blood containing tissue. The method also includes the steps of providing calibration samples, determining if the spectral intensities v. wavelengths from the tissue represents an outlier, and determining if any of the calibration samples represents an outlier. The determination of the unknown values is performed by at least one multivariate algorithm using two or more variables and at least one calibration model. Preferably, there is a separate calibration for each blood gas parameter being determined. The method can be utilized in a pulse mode and can also be used invasively. The apparatus includes a tissue positioning device, a source, at least one detector, electronics, a microprocessor, memory, and apparatus for indicating the determined values.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 1994},
month = {Sat Jan 01 00:00:00 EST 1994}
}
Works referenced in this record:
Comparison of Linear Statistical Methods for Calibration of NIR Instruments
journal, January 1986
- Naes, T.; Irgens, C.; Martens, H.
- Applied Statistics, Vol. 35, Issue 2