Stable radiometal antibody immunoconjugates
Abstract
The present invention relates to new rigid chelating structures, to methods for preparing these materials, and to their use in preparing radiometal labeled immunoconjugates. These new chelates include cyclohexyl EDTA monohydride, the trans forms of cyclohexyl DTPA and TTHA, and derivatives of these cyclohexyl polyaminocarboxylate materials.
- Inventors:
-
- Coram, NY
- Setauket, NY
- Oudon, FR
- Issue Date:
- Research Org.:
- Associated Universities, Inc., Upton, NY (United States)
- OSTI Identifier:
- 869422
- Patent Number(s):
- 5334729
- Assignee:
- Associated Universities, Inc. (Washington, DC)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- stable; radiometal; antibody; immunoconjugates; relates; rigid; chelating; structures; methods; preparing; materials; labeled; chelates; cyclohexyl; edta; monohydride; trans; forms; dtpa; ttha; derivatives; polyaminocarboxylate; stable radiometal; radiometal antibody; radiometal labeled; rigid chelating; polyaminocarboxylate materials; preparing radiometal; chelating structures; cyclohexyl edta; antibody immunoconjugates; labeled immunoconjugates; cyclohexyl dtpa; edta monohydride; cyclohexyl polyaminocarboxylate; /999/
Citation Formats
Mease, Ronnie C, Srivastava, Suresh C, and Gestin, Jean-Francois. Stable radiometal antibody immunoconjugates. United States: N. p., 1994.
Web.
Mease, Ronnie C, Srivastava, Suresh C, & Gestin, Jean-Francois. Stable radiometal antibody immunoconjugates. United States.
Mease, Ronnie C, Srivastava, Suresh C, and Gestin, Jean-Francois. Sat .
"Stable radiometal antibody immunoconjugates". United States. https://www.osti.gov/servlets/purl/869422.
@article{osti_869422,
title = {Stable radiometal antibody immunoconjugates},
author = {Mease, Ronnie C and Srivastava, Suresh C and Gestin, Jean-Francois},
abstractNote = {The present invention relates to new rigid chelating structures, to methods for preparing these materials, and to their use in preparing radiometal labeled immunoconjugates. These new chelates include cyclohexyl EDTA monohydride, the trans forms of cyclohexyl DTPA and TTHA, and derivatives of these cyclohexyl polyaminocarboxylate materials.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Jan 01 00:00:00 EST 1994},
month = {Sat Jan 01 00:00:00 EST 1994}
}
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