Boronated porphyrin compounds
Abstract
A compound is described having the structure ##STR1## where R preferably is ##STR2## and most preferably R.sup.3 is a closo-carborane and R.sup.2 is --H, an alkyl or aryl having 1 to about 7 carbon atoms, This invention was made with Government support under NIH Grant No. CA-37961 awarded by the Department of Health and Human Services and under the Associated Universities Inc. Contract No. De-AC02-76CH00016 with the U.S. Department of Energy. The Government has rights in this invention.
- Inventors:
-
- Portola Valley, CA
- San Francisco, CA
- Issue Date:
- Research Org.:
- Associated Universities, Inc., Upton, NY (United States)
- OSTI Identifier:
- 868475
- Patent Number(s):
- 5149801
- Assignee:
- Regents of University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- boronated; porphyrin; compounds; compound; described; structure; str1; preferably; str2; closo-carborane; -h; alkyl; aryl; carbon; atoms; government; support; nih; grant; ca-37961; awarded; department; health; human; services; associated; universities; contract; de-ac02-76ch00016; energy; rights; carbon atoms; carbon atom; government support; associated universities; human services; porphyrin compounds; /999/514/
Citation Formats
Kahl, Stephen B, and Koo, Myoung-Seo. Boronated porphyrin compounds. United States: N. p., 1992.
Web.
Kahl, Stephen B, & Koo, Myoung-Seo. Boronated porphyrin compounds. United States.
Kahl, Stephen B, and Koo, Myoung-Seo. Wed .
"Boronated porphyrin compounds". United States. https://www.osti.gov/servlets/purl/868475.
@article{osti_868475,
title = {Boronated porphyrin compounds},
author = {Kahl, Stephen B and Koo, Myoung-Seo},
abstractNote = {A compound is described having the structure ##STR1## where R preferably is ##STR2## and most preferably R.sup.3 is a closo-carborane and R.sup.2 is --H, an alkyl or aryl having 1 to about 7 carbon atoms, This invention was made with Government support under NIH Grant No. CA-37961 awarded by the Department of Health and Human Services and under the Associated Universities Inc. Contract No. De-AC02-76CH00016 with the U.S. Department of Energy. The Government has rights in this invention.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 1992},
month = {Wed Jan 01 00:00:00 EST 1992}
}
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Works referenced in this record:
Boron Neutron Capture Therapy for Cancer
journal, October 1990
- Barth, Rolf F.; Soloway, Albert H.; Fairchild, Ralph G.
- Scientific American, Vol. 263, Issue 4
Protein-binding polyhedral boranes. 1
journal, August 1974
- Sneath, R. L.; Soloway, A. H.; Dey, A. S.
- Journal of Medicinal Chemistry, Vol. 17, Issue 8
Optimization of Boron and Neutron Delivery for Neutron Capture Therapy
journal, July 1989
- Fairchild, R. G.; Slatkin, D. N.; Coderre, J. A.
- Pigment Cell Research, Vol. 2, Issue 4
Boron hydride derivatives for neutron capture therapy. Antibody approach
journal, August 1974
- Wong, Hou S.; Tolpin, Eugene I.; Lipscomb, William N.
- Journal of Medicinal Chemistry, Vol. 17, Issue 8
Preparation of carboranyl porphyrins for boron neutron capture therapy
journal, January 1990
- Miura, Michiko; Gabel, Detlef; Oenbrink, Georg
- Tetrahedron Letters, Vol. 31, Issue 16
Treatment of Malignant Melanoma by Single Thermal Neutron Capture Therapy with Melanoma-Seeking 10b-Compound
journal, August 1989
- Mishima, Yutaka; Honda, Chihiro; Ichihashi, Masamitsu
- The Lancet, Vol. 334, Issue 8659
Preparation of tumor-specific boron compounds. 1. In vitro studies using boron-labeled antibodies and elemental boron as neutron targets
journal, May 1972
- Hawthorne, M. Frederick; Wiersema, Richard J.; Takasugi, Mitsuo
- Journal of Medicinal Chemistry, Vol. 15, Issue 5
Distribution of 10B after infusion of Na210B12H11SH into a patient with malignant astrocytoma: implications for boron neutron capture therapy
journal, January 1989
- Finkel, G. C.; Poletti, C. E.; Fairchild, R. G.
- Neurosurgery, Vol. 24, Issue 1