Triamines and their derivatives as bifunctional chelating agents

Troutner, David E; John, Christy S; Pillai, Maroor R. A.

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Title: Triamines and their derivatives as bifunctional chelating agents

Abstract

A group of functionalized triamine chelants and their derivatives that form complexes with radioactive metal ions are disclosed. The complexes can be covalently attached to a protein or an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes.

Inventors:

Troutner, David E ^[1]; John, Christy S ^[2]; Pillai, Maroor R. A. ^[1]

Columbia, MO
Hovertown, PA

Issue Date:: Wed Jan 01 00:00:00 EST 1992

Research Org.:: Univ. of Missouri, Columbia, MO (United States)

OSTI Identifier:: 868223

Patent Number(s):: 5101041

Application Number:: 07/343,472

Assignee:: Curators of University of Missouri (Columbia, MO)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2123/00 - Preparations for testing in vivo
A61K51/1093 - {conjugates with carriers being antibodies}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
C07C215/50 - with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
C07C251/38 - to carbon atoms of a saturated carbon skeleton

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
C07D207/335 - Radicals substituted by nitrogen atoms not forming part of a nitro radical
C07D213/38 - having only hydrogen, hydrocarbon radicals attached to the substituent nitrogen atom

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F13/005 - {Compounds without a metal-carbon linkage}

Show less

DOE Contract Number:: FG02-86ER60400

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: triamines; derivatives; bifunctional; chelating; agents; functionalized; triamine; chelants; form; complexes; radioactive; metal; disclosed; covalently; attached; protein; antibody; fragment; therapeutic; diagnostic; purposes; bifunctional chelating; radioactive metal; active metal; chelating agents; chelating agent; triamine chelants; antibody fragment; diagnostic purposes; covalently attached; functionalized triamine; form complexes; /999/424/530/

Citation Formats


                    Troutner, David E, John, Christy S, and Pillai, Maroor R. A. Triamines and their derivatives as bifunctional chelating agents.  United States: N. p., 1992. 
        Web.

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                    Troutner, David E, John, Christy S, & Pillai, Maroor R. A. Triamines and their derivatives as bifunctional chelating agents.  United States.

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                    Troutner, David E, John, Christy S, and Pillai, Maroor R. A. Wed .  
        "Triamines and their derivatives as bifunctional chelating agents".  United States.  https://www.osti.gov/servlets/purl/868223.

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@article{osti_868223,

  title        = {Triamines and their derivatives as bifunctional chelating agents},

  author       = {Troutner, David E and John, Christy S and Pillai, Maroor R. A.},

  abstractNote = {A group of functionalized triamine chelants and their derivatives that form complexes with radioactive metal ions are disclosed. The complexes can be covalently attached to a protein or an antibody or antibody fragment and used for therapeutic and/or diagnostic purposes.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Wed Jan 01 00:00:00 EST 1992},

  month        = {Wed Jan 01 00:00:00 EST 1992}

}

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Works referenced in this record:

Cobalt(III) Complexes with 4-Methyldiethylene-triamine[2,2'-Methyliminodi(ethylamine)]: Their Separation, Characterization and Reactions
journal, January 1979

Searle, Gh; Lincoln, Sf; Teague, Sg
Australian Journal of Chemistry, Vol. 32, Issue 3
https://doi.org/10.1071/CH9790519

Formation and stabilities of cobalt(II) chelates of N-benzyl triamine Schiff bases and their dioxygen complexes
journal, February 1984

Motekaitis, Ramunas J.; Martell, Arthur E.; Nelson, David A.
Inorganic Chemistry, Vol. 23, Issue 3
https://doi.org/10.1021/ic00171a005

Synthesis of 1-(p-isothiocyanatobenzyl) derivatives of DTPA and EDTA. Antibody labeling and tumor-imaging studies
journal, July 1986

Brechbiel, Martin W.; Gansow, Otto A.; Atcher, Robert W.
Inorganic Chemistry, Vol. 25, Issue 16
https://doi.org/10.1021/ic00236a024

Some iron(III) complexes with polydentate Schiff base ligands
journal, July 1988

Addison, Anthony W.; Wahlgren, Curtis G.
Inorganica Chimica Acta, Vol. 147, Issue 1
https://doi.org/10.1016/S0020-1693(00)80630-1

Technetium( V ) and rhenium( V ) complexes with Schiff-base ligands containing the ONNNO donor atom set. Crystal structure of [N,N′-3-azapentane-1,5-diylbis(salicylideneiminato)(3–)-O,O′,N,N′,N″]-oxotechnetium( V )
journal, January 1988

Refosco, Fiorenzo; Tisato, Francesco; Mazzi, Ulderico
J. Chem. Soc., Dalton Trans., Issue 3
https://doi.org/10.1039/DT9880000611

Synthesis, plasma clearance, and in vitro stability of protein containing a conjugated indium-111 chelate
journal, September 1980

Paik, C. H.; Herman, D. E.; Eckelman, W. C.
Journal of Radioanalytical Chemistry, Vol. 57, Issue 2
https://doi.org/10.1007/BF02516765

Comparative evaluation of 99mTc-labeled aminothiols as possible brain perfusion imaging agents
journal, January 1988

Chiotellis, E.; Varvarigou, A. D.; Maina, Th.
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, Vol. 15, Issue 2
https://doi.org/10.1016/0883-2897(88)90091-8

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Similar Records

Title: Triamines and their derivatives as bifunctional chelating agents

Abstract

Citation Formats

Cobalt(III) Complexes with 4-Methyldiethylene-triamine[2,2'-Methyliminodi(ethylamine)]: Their Separation, Characterization and Reactions journal, January 1979

Formation and stabilities of cobalt(II) chelates of N-benzyl triamine Schiff bases and their dioxygen complexes journal, February 1984

Synthesis of 1-(p-isothiocyanatobenzyl) derivatives of DTPA and EDTA. Antibody labeling and tumor-imaging studies journal, July 1986

Some iron(III) complexes with polydentate Schiff base ligands journal, July 1988

Technetium( V ) and rhenium( V ) complexes with Schiff-base ligands containing the ONNNO donor atom set. Crystal structure of [N,N′-3-azapentane-1,5-diylbis(salicylideneiminato)(3–)-O,O′,N,N′,N″]-oxotechnetium( V ) journal, January 1988

Synthesis, plasma clearance, and in vitro stability of protein containing a conjugated indium-111 chelate journal, September 1980

Comparative evaluation of 99mTc-labeled aminothiols as possible brain perfusion imaging agents journal, January 1988

Cobalt(III) Complexes with 4-Methyldiethylene-triamine[2,2'-Methyliminodi(ethylamine)]: Their Separation, Characterization and Reactions
journal, January 1979

Formation and stabilities of cobalt(II) chelates of N-benzyl triamine Schiff bases and their dioxygen complexes
journal, February 1984

Synthesis of 1-(p-isothiocyanatobenzyl) derivatives of DTPA and EDTA. Antibody labeling and tumor-imaging studies
journal, July 1986

Some iron(III) complexes with polydentate Schiff base ligands
journal, July 1988

Technetium( V ) and rhenium( V ) complexes with Schiff-base ligands containing the ONNNO donor atom set. Crystal structure of [N,N′-3-azapentane-1,5-diylbis(salicylideneiminato)(3–)-O,O′,N,N′,N″]-oxotechnetium( V )
journal, January 1988

Synthesis, plasma clearance, and in vitro stability of protein containing a conjugated indium-111 chelate
journal, September 1980

Comparative evaluation of 99mTc-labeled aminothiols as possible brain perfusion imaging agents
journal, January 1988