Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents

Jones, Alun G; Davison, Alan; Abrams, Michael J

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Title: Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents

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Abstract

A method for preparing a coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta is disclosed. The method comprises preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal isonitrile salt with a salt comprising said radioactive metal in a suitable solvent to displace said displaceable metal with the radioactive metal thereby forming said coordination. The complex is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.

Inventors:

Jones, Alun G ^[1]; Davison, Alan ^[2]; Abrams, Michael J ^[3]

Newton Centre, MA
Needham, MA
Westchester, PA

Issue Date:: Thu Jan 01 00:00:00 EST 1987

Research Org.:: Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)

OSTI Identifier:: 866429

Patent Number(s):: 4707544

Assignee:: President and Fellows of Harvard College (Cambridge, MA); Massachusetts Institute of Technology (Cambridge, MA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2123/00 - Preparations for testing in vivo
A61K51/0476 - {complexes from monodendate ligands, e.g. sestamibi}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07F - ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
C07F13/00 - Compounds containing elements of Groups 7 or 17 of the Periodic System
C07F3/06 - Zinc compounds

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DOE Contract Number:: AC02-81EV10649

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: metal-isonitrile; adducts; preparing; radionuclide; complexes; labelling; imaging; agents; method; coordination; complex; isonitrile; ligand; tc; ru; mn; pd; nb; disclosed; comprises; soluble; metal; adduct; admixing; salt; displaceable; complete; d-electron; shell; selected; consisting; zn; cd; hg; pb; form; comprising; radioactive; suitable; solvent; displace; forming; useful; diagnostic; agent; liposomes; vesicles; living; cells; containing; lipid; membranes; blood; clots; myocardial; tissue; gall; bladder; etc; radionuclide complexes; radioactive metal; living cells; isonitrile ligand; imaging agents; active metal; suitable solvent; method comprises; soluble metal; cells containing; method comprise; coordination complex; imaging agent; comprises preparing; myocardial tissue; lipid membranes; cells contain; diagnostic agent; /424/999/987/

Citation Formats


                    Jones, Alun G, Davison, Alan, and Abrams, Michael J. Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents.  United States: N. p., 1987. 
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                    Jones, Alun G, Davison, Alan, & Abrams, Michael J. Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents.  United States.

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                    Jones, Alun G, Davison, Alan, and Abrams, Michael J. Thu .  
        "Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents".  United States.  https://www.osti.gov/servlets/purl/866429.

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@article{osti_866429,

  title        = {Metal-isonitrile adducts for preparing radionuclide complexes for labelling and imaging agents},

  author       = {Jones, Alun G and Davison, Alan and Abrams, Michael J},

  abstractNote = {A method for preparing a coordination complex of an isonitrile ligand and radionuclide such as Tc, Ru, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb and Ta is disclosed. The method comprises preparing a soluble metal adduct of said isonitrile ligand by admixing said ligand with a salt of a displaceable metal having a complete d-electron shell selected from the group consisting of Zn, Ga, Cd, In, Sn, Hg, Tl, Pb and Bi to form a soluble metal-isonitrile salt, and admixing said metal isonitrile salt with a salt comprising said radioactive metal in a suitable solvent to displace said displaceable metal with the radioactive metal thereby forming said coordination. The complex is useful as a diagnostic agent for labelling liposomes or vesicles, and selected living cells containing lipid membranes, such as blood clots, myocardial tissue, gall bladder tissue, etc.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Thu Jan 01 00:00:00 EST 1987},

  month        = {Thu Jan 01 00:00:00 EST 1987}

}

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