Sensor array and apparatus for simultaneous observation of tissue electrophysiology, contractility, and growth
Abstract
A sensor array for simultaneously measuring electrophysiological responses and contractility responses of a tissue includes: a substrate; a multi-electrode array (MEA) disposed in or on the substrate; and a plurality of interdigitized electrodes (IDEs) disposed in or on the substrate. The MEA and the IDEs are interpenetrating within a plane substantially parallel to an upper surface of the substrate. Systems for measuring such responses using the sensor array may also include contacts and/or connectors for interfacing with external control devices, electrodes, and cell culture components such as a chamber and lid. Fabrication techniques for making such systems include: forming a sensor array comprising an interpenetrating arrangement of IDEs and electrodes of a MEA in or on a substrate surface; forming a plurality of contacts for interfacing the system with one or more external devices in or on the substrate surface; and forming leads between the plurality of contacts and the sensor array.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1805496
- Patent Number(s):
- 10914722
- Application Number:
- 15/901,766
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12M - APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 02/21/2018
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Qian, Fang, Huang, Chienjin, Ivanovskaya, Anna Nikolaevna, Kulp, Kris, and Wheeler, Elizabeth K. Sensor array and apparatus for simultaneous observation of tissue electrophysiology, contractility, and growth. United States: N. p., 2021.
Web.
Qian, Fang, Huang, Chienjin, Ivanovskaya, Anna Nikolaevna, Kulp, Kris, & Wheeler, Elizabeth K. Sensor array and apparatus for simultaneous observation of tissue electrophysiology, contractility, and growth. United States.
Qian, Fang, Huang, Chienjin, Ivanovskaya, Anna Nikolaevna, Kulp, Kris, and Wheeler, Elizabeth K. Tue .
"Sensor array and apparatus for simultaneous observation of tissue electrophysiology, contractility, and growth". United States. https://www.osti.gov/servlets/purl/1805496.
@article{osti_1805496,
title = {Sensor array and apparatus for simultaneous observation of tissue electrophysiology, contractility, and growth},
author = {Qian, Fang and Huang, Chienjin and Ivanovskaya, Anna Nikolaevna and Kulp, Kris and Wheeler, Elizabeth K.},
abstractNote = {A sensor array for simultaneously measuring electrophysiological responses and contractility responses of a tissue includes: a substrate; a multi-electrode array (MEA) disposed in or on the substrate; and a plurality of interdigitized electrodes (IDEs) disposed in or on the substrate. The MEA and the IDEs are interpenetrating within a plane substantially parallel to an upper surface of the substrate. Systems for measuring such responses using the sensor array may also include contacts and/or connectors for interfacing with external control devices, electrodes, and cell culture components such as a chamber and lid. Fabrication techniques for making such systems include: forming a sensor array comprising an interpenetrating arrangement of IDEs and electrodes of a MEA in or on a substrate surface; forming a plurality of contacts for interfacing the system with one or more external devices in or on the substrate surface; and forming leads between the plurality of contacts and the sensor array.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Feb 09 00:00:00 EST 2021},
month = {Tue Feb 09 00:00:00 EST 2021}
}
Works referenced in this record:
Electrodes, methods, apparatuses comprising micro-electrode arrays
patent, October 2007
- Wilsey, Christopher D.
- US Patent Document 7,276,146
Impedance based devices and methods for use in assays
patent, December 2008
- Xu, Xiao; Wang, Xiaobo
- US Patent Document 7,470,533
Apparatus for measuring the electrophysiological activity of a group of cells
patent, May 2004
- Hänni, Claude; Stoppini, Luc
- US Patent Document 6,730,199