Compositions for therapeutics, targeted PET imaging and methods of their use
Abstract
Described herein is a chelator for radiolabels (e.g., 89Zr) for targeted PET imaging that is an alternative to DFO. In certain embodiments, the chelator for 89Zr is the ligand, 3,4,3-(LI-1,2-HOPO) (“HOPO”), which exhibits equal or superior stability compared to DFO in chemical and biological assays across a period of several days in vivo. As shown in FIG. 1, the HOPO is an octadentate chelator that stabilizes chelation of radiolabels (e.g., 89Zr). A bifunctional ligand comprising p-SCN-Bn-HOPO is shown in FIG. 4 and FIG. 5. Such a bifunctional ligand can eliminate (e.g., 89Zr) loss from the chelate in vivo and reduce uptake in bone and non-target tissue. Therefore, the bifunctional HOPO ligand can facilitate safer and improved PET imaging with radiolabeled antibodies.
- Inventors:
- Issue Date:
- Research Org.:
- Memorial Sloan Kettering Cancer Center, New York, NY (United States); City Univ. of New York (CUNY), New York, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1771572
- Patent Number(s):
- 10821195
- Application Number:
- 15/759,154
- Assignee:
- Memorial Sloan-Kettering Cancer Center (New York, NY); The Research Foundation for The State University of New York (New York, NY)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- SC0001789; SC0002456; TR000457
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 09/09/2016
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Lewis, Jason S., Deri, Melissa, Francesconi, Lynn, and Ponnala, Shashikanth. Compositions for therapeutics, targeted PET imaging and methods of their use. United States: N. p., 2020.
Web.
Lewis, Jason S., Deri, Melissa, Francesconi, Lynn, & Ponnala, Shashikanth. Compositions for therapeutics, targeted PET imaging and methods of their use. United States.
Lewis, Jason S., Deri, Melissa, Francesconi, Lynn, and Ponnala, Shashikanth. Tue .
"Compositions for therapeutics, targeted PET imaging and methods of their use". United States. https://www.osti.gov/servlets/purl/1771572.
@article{osti_1771572,
title = {Compositions for therapeutics, targeted PET imaging and methods of their use},
author = {Lewis, Jason S. and Deri, Melissa and Francesconi, Lynn and Ponnala, Shashikanth},
abstractNote = {Described herein is a chelator for radiolabels (e.g., 89Zr) for targeted PET imaging that is an alternative to DFO. In certain embodiments, the chelator for 89Zr is the ligand, 3,4,3-(LI-1,2-HOPO) (“HOPO”), which exhibits equal or superior stability compared to DFO in chemical and biological assays across a period of several days in vivo. As shown in FIG. 1, the HOPO is an octadentate chelator that stabilizes chelation of radiolabels (e.g., 89Zr). A bifunctional ligand comprising p-SCN-Bn-HOPO is shown in FIG. 4 and FIG. 5. Such a bifunctional ligand can eliminate (e.g., 89Zr) loss from the chelate in vivo and reduce uptake in bone and non-target tissue. Therefore, the bifunctional HOPO ligand can facilitate safer and improved PET imaging with radiolabeled antibodies.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Nov 03 00:00:00 EST 2020},
month = {Tue Nov 03 00:00:00 EST 2020}
}
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