Bis-polymer lipid-peptide conjugates and nanoparticles thereof

Xu, Ting; Dong, He; Shu, Jessica; Dube, Nikhil

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Title: Bis-polymer lipid-peptide conjugates and nanoparticles thereof

Abstract

The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.

Inventors:: Xu, Ting; Dong, He; Shu, Jessica; Dube, Nikhil

Issue Date:: Tue Oct 20 00:00:00 EDT 2020

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1771519

Patent Number(s):: 10806702

Application Number:: 15/961,111

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2300/00 - Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
A61K31/337 - having four-membered rings, e.g. taxol
A61K31/436 - the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K31/704 - attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {
A61K47/42 - Proteins
A61K47/62 - the modifying agent being a protein, peptide or polyamino acid
A61K47/6907 - {the form being a microemulsion, nanoemulsion or micelle}
A61K51/1227 - {Micelles, e.g. phospholipidic or polymeric micelles}
A61K9/1075 - {Microemulsions or submicron emulsions

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DOE Contract Number:: AC02-05CH11231

Resource Type:: Patent

Resource Relation:: Patent File Date: 04/24/2018

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES

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                    Xu, Ting, Dong, He, Shu, Jessica, and Dube, Nikhil. Bis-polymer lipid-peptide conjugates and nanoparticles thereof.  United States: N. p., 2020. 
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                    Xu, Ting, Dong, He, Shu, Jessica, & Dube, Nikhil. Bis-polymer lipid-peptide conjugates and nanoparticles thereof.  United States.

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                    Xu, Ting, Dong, He, Shu, Jessica, and Dube, Nikhil. Tue .  
        "Bis-polymer lipid-peptide conjugates and nanoparticles thereof".  United States.  https://www.osti.gov/servlets/purl/1771519.

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@article{osti_1771519,

  title        = {Bis-polymer lipid-peptide conjugates and nanoparticles thereof},

  author       = {Xu, Ting and Dong, He and Shu, Jessica and Dube, Nikhil},

  abstractNote = {The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Oct 20 00:00:00 EDT 2020},

  month        = {Tue Oct 20 00:00:00 EDT 2020}

}

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