Rhodol fluorophores for near-infrared imaging
Abstract
The present disclosure encompasses embodiments of a novel near-infrared-emitting molecular fluorophore and probes incorporating said fluorophore advantageous for in vitro and in vivo research studies. The fluorophore is robust, photostable, and possesses functionalities for easy bioorthogonal conjugation (e.g., click chemistry, hydrazone formation, Diels Alder, Staudinger ligation, etc.). It is biocompatible and emits at 711 nm in aqueous conditions. These fluorophores may be used to fluorescently tag biological molecules or structures of interest, or used as optical reporters (i.e., activatable molecular probes, fluorescent dyes) for specific biomarkers/analytes as they can be switched from “off” to “on.” This fluorophore is useful for cellular assays and preclinical small animal imaging as the near-infrared emission is highly penetrating, and the photophysical properties are outstanding. As such, the properties of this class of fluorophores could easily be translated for use in clinical applications.
- Inventors:
- Issue Date:
- Research Org.:
- Leland Stanford Junior Univ., Palo Alto, CA (United States); Univ. of Missouri, Columbia, MO (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1650982
- Patent Number(s):
- 10675364
- Application Number:
- 15/738,327
- Assignee:
- The Board of Trustees of the Leland Stanford Junior University (Palo Alto, CA); The Curators of the University of Missouri (Columbia, MO)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- DOE Contract Number:
- SC0008397
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 06/23/2016
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 47 OTHER INSTRUMENTATION
Citation Formats
Hettie, Kenneth, Klockow, Jessica L, Glass, Timothy, and Chin, Frederick T. Rhodol fluorophores for near-infrared imaging. United States: N. p., 2020.
Web.
Hettie, Kenneth, Klockow, Jessica L, Glass, Timothy, & Chin, Frederick T. Rhodol fluorophores for near-infrared imaging. United States.
Hettie, Kenneth, Klockow, Jessica L, Glass, Timothy, and Chin, Frederick T. Tue .
"Rhodol fluorophores for near-infrared imaging". United States. https://www.osti.gov/servlets/purl/1650982.
@article{osti_1650982,
title = {Rhodol fluorophores for near-infrared imaging},
author = {Hettie, Kenneth and Klockow, Jessica L and Glass, Timothy and Chin, Frederick T.},
abstractNote = {The present disclosure encompasses embodiments of a novel near-infrared-emitting molecular fluorophore and probes incorporating said fluorophore advantageous for in vitro and in vivo research studies. The fluorophore is robust, photostable, and possesses functionalities for easy bioorthogonal conjugation (e.g., click chemistry, hydrazone formation, Diels Alder, Staudinger ligation, etc.). It is biocompatible and emits at 711 nm in aqueous conditions. These fluorophores may be used to fluorescently tag biological molecules or structures of interest, or used as optical reporters (i.e., activatable molecular probes, fluorescent dyes) for specific biomarkers/analytes as they can be switched from “off” to “on.” This fluorophore is useful for cellular assays and preclinical small animal imaging as the near-infrared emission is highly penetrating, and the photophysical properties are outstanding. As such, the properties of this class of fluorophores could easily be translated for use in clinical applications.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 09 00:00:00 EDT 2020},
month = {Tue Jun 09 00:00:00 EDT 2020}
}
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