Systems and methods for relay ionization

Cooks, Robert Graham; Li, Anyin; Hollerbach, Adam

Title: Systems and methods for relay ionization

Abstract

The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.

Inventors:: Cooks, Robert Graham; Li, Anyin; Hollerbach, Adam

Issue Date:: Tue Mar 03 00:00:00 EST 2020

Research Org.:: Purdue Univ., West Lafayette, IN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1632639

Patent Number(s):: 10580634

Application Number:: 16/518,291

Assignee:: Purdue Research Foundation (West Lafayette, IN)

Patent Classifications (CPCs):: H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

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H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/00 - Particle spectrometers or separator tubes
H01J49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks
H01J49/0409 - {Sample holders or containers
H01J49/165 - {Electrospray ionisation}
H01J49/167 - {Capillaries and nozzles specially adapted therefor

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DOE Contract Number:: FG02-06ER15807

Resource Type:: Patent

Resource Relation:: Patent File Date: 07/22/2019

Country of Publication:: United States

Language:: English

Subject:: 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

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                    Cooks, Robert Graham, Li, Anyin, and Hollerbach, Adam. Systems and methods for relay ionization.  United States: N. p., 2020. 
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                    Cooks, Robert Graham, Li, Anyin, & Hollerbach, Adam. Systems and methods for relay ionization.  United States.

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                    Cooks, Robert Graham, Li, Anyin, and Hollerbach, Adam. Tue .  
        "Systems and methods for relay ionization".  United States.  https://www.osti.gov/servlets/purl/1632639.

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@article{osti_1632639,

  title        = {Systems and methods for relay ionization},

  author       = {Cooks, Robert Graham and Li, Anyin and Hollerbach, Adam},

  abstractNote = {The invention generally relates to systems and methods for relay ionization of a sample. In certain aspects, the invention provides systems that include an ion source that generates ions, a sample emitter configured to hold a sample, and a mass spectrometer. The system is configured such that the ions generated by the ion source are directed to interact with the sample emitter, thereby causing the sample to be discharged from the sample emitter and into the mass spectrometer.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Mar 03 00:00:00 EST 2020},

  month        = {Tue Mar 03 00:00:00 EST 2020}

}

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Lafrenière, Nelson M.; Shih, Steve CC; Abu-Rabie, Paul
Bioanalysis, Vol. 6, Issue 3
https://doi.org/10.4155/bio.13.311

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Title: Systems and methods for relay ionization

Abstract

Citation Formats

Method and apparatus for electrospray ionization patent, October 2001

Atmospheric pressure ionization mass spectrometry. Corona discharge ion source for use in a liquid chromatograph-mass spectrometer-computer analytical system journal, December 1975

Efficient Separations of Intact Proteins Using Slip-Flow with Nano-Liquid Chromatography–Mass Spectrometry journal, January 2014

Systems and Methods for Analyzing a Sample Using a Mass Spectrometry Probe Configured to Contact the Sample patent-application, September 2014

Analysis of Polycyclic Aromatic Hydrocarbons Using Desorption Atmospheric Pressure Chemical Ionization Coupled to a Portable Mass Spectrometer journal, December 2014

Durable Gold-Coated Fused Silica Capillaries for Use in Electrospray Mass Spectrometry journal, January 1995

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Inkjet-Printed Microfluidic Multianalyte Chemical Sensing Paper journal, September 2008

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Synthesis and Catalytic Reactions of Nanoparticles formed by Electrospray Ionization of Coinage Metals journal, February 2014

Theta-Glass Capillaries in Electrospray Ionization: Rapid Mixing and Short Droplet Lifetimes journal, September 2014

Molecular Beams of Macroions. II journal, May 1970

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Molecular Beams of Macroions journal, September 1968

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Interface solution isoelectric focusing with in situ MALDI-TOF mass spectrometry: Microfluidics and Miniaturization journal, June 2014

Low Temperature Plasma Probe and Methods of Use Thereof patent-application, February 2011

Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation journal, January 2006

Ion Transfer Tube for a Mass Spectrometer System patent-application, June 2012

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Miniaturized Source Devices for Optical and Mass Spectrometry patent-application, September 2005

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Method and apparatus for the mass spectrometric analysis of solutions patent, July 1985

Live single-cell video-mass spectrometry for cellular and subcellular molecular detection and cell classification journal, December 2008

Process and apparatus for changing the energy of charged particles contained in a gaseous medium patent, September 1985

Mass Spectrometry Apparatus patent-application, November 2013

Mass Analyzing Apparatus patent-application, November 2008

Miniaturization and Geometry Optimization of a Polymer-Based Rectilinear Ion Trap journal, October 2007

Paper spray ionization of polar analytes using non-polar solvents journal, January 2011

Current measurements within the electrospray emitter journal, April 2007

Shiga-Like Toxin II Derived from Escherichia coli O157:H7 Modifies Renal Handling of Levofloxacin in Rats journal, May 2002

Method and Apparatus for Multiple Electrospray Emitters in Mass Spectrometry patent-application, June 2011

FLASH: A rapid method for prototyping paper-based microfluidic devices journal, January 2008

Ion generation using wetted porous material patent, October 2014

Surface Acoustic Wave Nebulization Facilitating Lipid Mass Spectrometric Analysis journal, July 2012

Soft Landing of Complex Molecules on Surfaces journal, July 2011

Nucleophilic Addition of Nitrogen to Aryl Cations: Mimicking Titan Chemistry journal, August 2013

Profiling pH Gradients Across Nanocapillary Array Membranes Connecting Microfluidic Channels journal, October 2005

Patterned Paper as a Platform for Inexpensive, Low-Volume, Portable Bioassays journal, February 2007

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Ionization by Droplet Impact patent-application, May 2006

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Enhanced silver cationization of polycyclic aromatic hydrocarbons containing bay regions in molecular secondary ion mass spectrometry journal, January 1989

Discontinuous atmospheric pressure interface patent, November 2012

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Mass Spectrometry Method, Mass Spectrometer, and Mass Spectrometry System patent-application, October 2013

New developments in biochemical mass spectrometry: electrospray ionization journal, May 1990

Laser Ablation Electrospray Ionization for Atmospheric Pressure, in Vivo, and Imaging Mass Spectrometry journal, November 2007

Characterization of dielectric barrier electrospray ionization for mass spectrometric detection journal, May 2010

Field induced ion evaporation from liquid surfaces at atmospheric pressure journal, December 1979

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules journal, November 2014

Enclosed Desorption Electrospray Ionization Probes and Method of Use Thereof patent-application, August 2015

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Method and system for desorption electrospray ionization patent, February 2008

Miniaturization of Mass Spectrometry Analysis Systems journal, December 2010

Electrospray Ionization from Nanopipette Emitters with Tip Diameters of Less than 100 nm journal, August 2013

Time-of-flight ion-scattering spectrometer for scattering and recoiling for electron density and structure patent, November 1991

Electrochemical processes in a wire-in-a-capillary bulk-loaded, nano-electrospray emitter journal, July 2001

Miniature Mass Spectrometers journal, July 2009

Handheld Rectilinear Ion Trap Mass Spectrometer journal, September 2006

Three-dimensional microfluidic devices fabricated in layered paper and tape journal, December 2008

In situ analysis of corrosion inhibitors using a portable mass spectrometer with paper spray ionization journal, January 2013

Electrospray Ionization Using Wooden Tips journal, November 2011

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On the evaporation of small ions from charged droplets journal, January 1976

Ion spray apparatus and method patent, August 1989

The Electrical Discharge from Liquid Points, and a Hydrostatic Method of Measuring the Electric Intensity at Their Surfaces journal, February 1914

Monitoring of Reaction Intermediates in the Gas Phase: Ruthenium-Catalyzed C–C Coupling journal, November 2014

Enhancement of the performance of organic solar cells by electrospray deposition with optimal solvent system journal, February 2014

Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry journal, January 2010

Electrospray ionization for mass spectrometry of large biomolecules journal, October 1989

Method and apparatus for electrospray ionization
patent, October 2001

Atmospheric pressure ionization mass spectrometry. Corona discharge ion source for use in a liquid chromatograph-mass spectrometer-computer analytical system
journal, December 1975

Efficient Separations of Intact Proteins Using Slip-Flow with Nano-Liquid Chromatography–Mass Spectrometry
journal, January 2014

Systems and Methods for Analyzing a Sample Using a Mass Spectrometry Probe Configured to Contact the Sample
patent-application, September 2014

Analysis of Polycyclic Aromatic Hydrocarbons Using Desorption Atmospheric Pressure Chemical Ionization Coupled to a Portable Mass Spectrometer
journal, December 2014

Durable Gold-Coated Fused Silica Capillaries for Use in Electrospray Mass Spectrometry
journal, January 1995

Low temperature plasma probe and methods of use thereof
patent, June 2015

Inkjet-Printed Microfluidic Multianalyte Chemical Sensing Paper
journal, September 2008

Electrospray ion source. Another variation on the free-jet theme
journal, September 1984

Synthesis and Catalytic Reactions of Nanoparticles formed by Electrospray Ionization of Coinage Metals
journal, February 2014

Theta-Glass Capillaries in Electrospray Ionization: Rapid Mixing and Short Droplet Lifetimes
journal, September 2014

Molecular Beams of Macroions. II
journal, May 1970

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journal, March 2009

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journal, February 2006

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journal, September 1968

A novel cold plasma jet generated by atmospheric dielectric barrier capillary discharge
journal, May 2006

Interface solution isoelectric focusing with in situ MALDI-TOF mass spectrometry: Microfluidics and Miniaturization
journal, June 2014

Low Temperature Plasma Probe and Methods of Use Thereof
patent-application, February 2011

Extractive electrospray ionization for direct analysis of undiluted urine, milk and other complex mixtures without sample preparation
journal, January 2006

Ion Transfer Tube for a Mass Spectrometer System
patent-application, June 2012

Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids
journal, January 2005

Miniaturized Source Devices for Optical and Mass Spectrometry
patent-application, September 2005

Capillary Electrophoresis with Electrospray Ionization Mass Spectrometric Detection for Single-Cell Metabolomics
journal, July 2009

Method and apparatus for the mass spectrometric analysis of solutions
patent, July 1985

Live single-cell video-mass spectrometry for cellular and subcellular molecular detection and cell classification
journal, December 2008

Process and apparatus for changing the energy of charged particles contained in a gaseous medium
patent, September 1985

Mass Spectrometry Apparatus
patent-application, November 2013

Mass Analyzing Apparatus
patent-application, November 2008

Miniaturization and Geometry Optimization of a Polymer-Based Rectilinear Ion Trap
journal, October 2007

Paper spray ionization of polar analytes using non-polar solvents
journal, January 2011

Current measurements within the electrospray emitter
journal, April 2007

Shiga-Like Toxin II Derived from Escherichia coli O157:H7 Modifies Renal Handling of Levofloxacin in Rats
journal, May 2002

Method and Apparatus for Multiple Electrospray Emitters in Mass Spectrometry
patent-application, June 2011

FLASH: A rapid method for prototyping paper-based microfluidic devices
journal, January 2008

Ion generation using wetted porous material
patent, October 2014

Surface Acoustic Wave Nebulization Facilitating Lipid Mass Spectrometric Analysis
journal, July 2012

Soft Landing of Complex Molecules on Surfaces
journal, July 2011

Nucleophilic Addition of Nitrogen to Aryl Cations: Mimicking Titan Chemistry
journal, August 2013

Profiling pH Gradients Across Nanocapillary Array Membranes Connecting Microfluidic Channels
journal, October 2005

Patterned Paper as a Platform for Inexpensive, Low-Volume, Portable Bioassays
journal, February 2007

Nano-electrospray ionization mass spectrometry: addressing analytical problems beyond routine
journal, March 2000

Direct monitoring of toxic compounds in air using a portable mass spectrometer
journal, February 2006

Ionization by Droplet Impact
patent-application, May 2006

Using Laser-Induced Acoustic Desorption/Electrospray Ionization Mass Spectrometry To Characterize Small Organic and Large Biological Compounds in the Solid State and in Solution Under Ambient Conditions
journal, February 2009

Enhanced silver cationization of polycyclic aromatic hydrocarbons containing bay regions in molecular secondary ion mass spectrometry
journal, January 1989

Discontinuous atmospheric pressure interface
patent, November 2012

Computer aided flood control modeling and management system
patent, December 1989

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patent-application, October 2013

New developments in biochemical mass spectrometry: electrospray ionization
journal, May 1990

Laser Ablation Electrospray Ionization for Atmospheric Pressure, in Vivo, and Imaging Mass Spectrometry
journal, November 2007

Characterization of dielectric barrier electrospray ionization for mass spectrometric detection
journal, May 2010

Field induced ion evaporation from liquid surfaces at atmospheric pressure
journal, December 1979

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules
journal, November 2014

Enclosed Desorption Electrospray Ionization Probes and Method of Use Thereof
patent-application, August 2015

Combined electrophoretic-separation and electrospray method and system
patent, June 1989

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patent, February 2008

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journal, December 2010

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journal, August 2013

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patent, November 1991

Electrochemical processes in a wire-in-a-capillary bulk-loaded, nano-electrospray emitter
journal, July 2001

Miniature Mass Spectrometers
journal, July 2009

Handheld Rectilinear Ion Trap Mass Spectrometer
journal, September 2006

Three-dimensional microfluidic devices fabricated in layered paper and tape
journal, December 2008

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journal, January 2013

Electrospray Ionization Using Wooden Tips
journal, November 2011

Method and system for desorption electrospray ionization
patent-application, October 2005

In situ generation of copper cations and complexation with tebuconazole in a hyphenation of electrochemistry with mass spectrometry
journal, March 2013

Microfabricated electrospray emitter arrays with integrated extractor and accelerator electrodes for the propulsion of small spacecraft
journal, June 2014

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journal, October 2005

On the evaporation of small ions from charged droplets
journal, January 1976

Ion spray apparatus and method
patent, August 1989

The Electrical Discharge from Liquid Points, and a Hydrostatic Method of Measuring the Electric Intensity at Their Surfaces
journal, February 1914

Monitoring of Reaction Intermediates in the Gas Phase: Ruthenium-Catalyzed C–C Coupling
journal, November 2014

Enhancement of the performance of organic solar cells by electrospray deposition with optimal solvent system
journal, February 2014

Paper Spray for Direct Analysis of Complex Mixtures Using Mass Spectrometry
journal, January 2010

Electrospray ionization for mass spectrometry of large biomolecules
journal, October 1989

Using Ambient Ion Beams to Write Nanostructured Patterns for Surface Enhanced Raman Spectroscopy
journal, September 2014

Low-Cost Printing of Poly(dimethylsiloxane) Barriers To Define Microchannels in Paper
journal, May 2008

Microfluidic capture and release of bacteria in a conical nanopore array
journal, January 2012