Micro fluidic system for single molecule imaging

Schwartz, David C.; Dimalanta, Eileen T.; de Pablo, Juan J.

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A - human necessities
A01 - agriculture
A21 - baking
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B - performing operations
B01 - physical or chemical processes or apparatus in general
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B04 - centrifugal apparatus or machines for carrying-out physical or chemical processes
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D01 - natural or man-made threads or fibres
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Title: Micro fluidic system for single molecule imaging

Abstract

Laminar flow of a carrier liquid and polymeric molecules through micro-channels is used to straighten the polymeric molecules and attach the straightened molecules to a wall of the micro-channel for subsequent treatment and analysis. Micro-channels can be manufactured using an elastic molding material. One micro-channel embodiment provides fluid flow using a standard laboratory centrifuge.

Inventors:: Schwartz, David C.; Dimalanta, Eileen T.; de Pablo, Juan J.

Issue Date:: Tue Mar 27 00:00:00 EDT 2012

Research Org.:: Wisconsin Alumni Research Foundation, Madison, WI (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1531728

Patent Number(s):: 8142708

Application Number:: 10/713,898

Assignee:: Wisconsin Alumni Research Foundation (Madison, WI)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N1/30 - Staining
G01N1/40 - Concentrating samples
G01N1/405 - {by adsorption or absorption}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/25 - including sample preparation

Show less

DOE Contract Number:: FG02-99ER62830; NIH HG00225

Resource Type:: Patent

Resource Relation:: Patent File Date: 2002-10-18

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Schwartz, David C., Dimalanta, Eileen T., and de Pablo, Juan J. Micro fluidic system for single molecule imaging.  United States: N. p., 2012. 
        Web.

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                    Schwartz, David C., Dimalanta, Eileen T., & de Pablo, Juan J. Micro fluidic system for single molecule imaging.  United States.

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                    Schwartz, David C., Dimalanta, Eileen T., and de Pablo, Juan J. Tue .  
        "Micro fluidic system for single molecule imaging".  United States.  https://www.osti.gov/servlets/purl/1531728.

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@article{osti_1531728,

  title        = {Micro fluidic system for single molecule imaging},

  author       = {Schwartz, David C. and Dimalanta, Eileen T. and de Pablo, Juan J.},

  abstractNote = {Laminar flow of a carrier liquid and polymeric molecules through micro-channels is used to straighten the polymeric molecules and attach the straightened molecules to a wall of the micro-channel for subsequent treatment and analysis. Micro-channels can be manufactured using an elastic molding material. One micro-channel embodiment provides fluid flow using a standard laboratory centrifuge.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Mar 27 00:00:00 EDT 2012},

  month        = {Tue Mar 27 00:00:00 EDT 2012}

}

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Works referenced in this record:

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Methods and apparatuses for characterization of single polymers
patent-application, June 2002

Chan, Eugene Y.; Gleich, Lance C.; Wellman, Parris S.
US Patent Application 09/783472; 20020081744
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patent, January 2003

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Integrated active flux microfluidic devices and methods
patent-application, March 2002

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Works referencing / citing this record:

Nanochannel device with three dimensional gradient by single step etching for molecular detection
patent, April 2016

Bai, Jingwei; Lin, Qinghuang; Stolovitzky, Gustavo A.
US Patent Document 9,322,061
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9322061

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Similar Records

Title: Micro fluidic system for single molecule imaging

Abstract

Citation Formats

Electron induced fluorescent method for nucleic acid sequencing patent-application, September 2003

Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action patent, July 2004

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system patent-application, September 2002

Field-inversion gel electrophoresis patent, April 1988

Image processing and analysis of individual nucleic acid molecules patent, February 1998

Method for optically manipulating polymer filaments patent, January 1992

Methods and compositions for the manipulation and characterization of individual nucleic acid molecules patent, May 2006

Gel inserts useful in electrophoresis patent, September 1987

Method for separating nucleic acids and nucleic acid probes patent, October 1991

Unitary microcapiliary and waveguide structure and method of fabrication patent, August 2002

Methods and apparatuses for characterization of single polymers patent-application, June 2002

Image processing and analysis of individual nucleic acid molecules patent, January 2003

Integrated active flux microfluidic devices and methods patent-application, March 2002

Acrylic microchannels and their use in electrophoretic applications patent, April 2000

Non-isotopic in-situ hybridization method for detection of nucleic acids patent, November 1999

Electrophoresis using alternating transverse electric fields patent, September 1984

Image processing and analysis of individual nucleic acid molecules patent, August 2003

Process for aligning macromolecules by passage of a meniscus and applications patent, July 2001

Methods and apparatuses for stretching polymers patent, February 2004

Method for imaging informational biological molecules on a semiconductor substrate patent, May 1994

DNA measuring method patent, October 1994

Nanoelectrode arrays patent, September 2000

Apparatus and method of analyzing nucleic acid molecules patent, September 1989

Polynucleotide reagents containing selectable cleavage sites patent, January 1995

Detection of particular nucleotide sequences patent, August 1988

Nanochannel device with three dimensional gradient by single step etching for molecular detection patent, April 2016

Electron induced fluorescent method for nucleic acid sequencing
patent-application, September 2003

Fluid conduction utilizing a reversible unsaturated siphon with tubarc porosity action
patent, July 2004

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
patent-application, September 2002

Field-inversion gel electrophoresis
patent, April 1988

Image processing and analysis of individual nucleic acid molecules
patent, February 1998

Method for optically manipulating polymer filaments
patent, January 1992

Methods and compositions for the manipulation and characterization of individual nucleic acid molecules
patent, May 2006

Gel inserts useful in electrophoresis
patent, September 1987

Method for separating nucleic acids and nucleic acid probes
patent, October 1991

Unitary microcapiliary and waveguide structure and method of fabrication
patent, August 2002

Methods and apparatuses for characterization of single polymers
patent-application, June 2002

Image processing and analysis of individual nucleic acid molecules
patent, January 2003

Integrated active flux microfluidic devices and methods
patent-application, March 2002

Acrylic microchannels and their use in electrophoretic applications
patent, April 2000

Non-isotopic in-situ hybridization method for detection of nucleic acids
patent, November 1999

Electrophoresis using alternating transverse electric fields
patent, September 1984

Image processing and analysis of individual nucleic acid molecules
patent, August 2003

Process for aligning macromolecules by passage of a meniscus and applications
patent, July 2001

Methods and apparatuses for stretching polymers
patent, February 2004

Method for imaging informational biological molecules on a semiconductor substrate
patent, May 1994

DNA measuring method
patent, October 1994

Nanoelectrode arrays
patent, September 2000

Apparatus and method of analyzing nucleic acid molecules
patent, September 1989

Polynucleotide reagents containing selectable cleavage sites
patent, January 1995

Detection of particular nucleotide sequences
patent, August 1988

Nanochannel device with three dimensional gradient by single step etching for molecular detection
patent, April 2016