Sequestration of carbon dioxide with hydrogen to useful products
Abstract
Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of Georgia, Athens, GA (United States); North Carolina State University, Raleigh, NC (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1525055
- Patent Number(s):
- 10227617
- Application Number:
- 15/410,205
- Assignee:
- University of Georgia Research Foundation, Inc. (Athens, GA); North Carolina State University (Raleigh, NC)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
- DOE Contract Number:
- AR0000081
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2017-01-19
- Country of Publication:
- United States
- Language:
- English
Citation Formats
Adams, Michael W. W., Kelly, Robert M., Hawkins, Aaron B., Menon, Angeli Lal, Lipscomb, Gina Lynette Pries, and Schut, Gerrit Jan. Sequestration of carbon dioxide with hydrogen to useful products. United States: N. p., 2019.
Web.
Adams, Michael W. W., Kelly, Robert M., Hawkins, Aaron B., Menon, Angeli Lal, Lipscomb, Gina Lynette Pries, & Schut, Gerrit Jan. Sequestration of carbon dioxide with hydrogen to useful products. United States.
Adams, Michael W. W., Kelly, Robert M., Hawkins, Aaron B., Menon, Angeli Lal, Lipscomb, Gina Lynette Pries, and Schut, Gerrit Jan. Tue .
"Sequestration of carbon dioxide with hydrogen to useful products". United States. https://www.osti.gov/servlets/purl/1525055.
@article{osti_1525055,
title = {Sequestration of carbon dioxide with hydrogen to useful products},
author = {Adams, Michael W. W. and Kelly, Robert M. and Hawkins, Aaron B. and Menon, Angeli Lal and Lipscomb, Gina Lynette Pries and Schut, Gerrit Jan},
abstractNote = {Provided herein are genetically engineered microbes that include at least a portion of a carbon fixation pathway, and in one embodiment, use molecular hydrogen to drive carbon dioxide fixation. In one embodiment, the genetically engineered microbe is modified to convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof at levels greater than a control microbe. Other products may also be produced. Also provided herein are cell free compositions that convert acetyl CoA, molecular hydrogen, and carbon dioxide to 3-hydroxypropionate, 4-hydroxybutyrate, acetyl CoA, or the combination thereof. Also provided herein are methods of using the genetically engineered microbes and the cell free compositions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Mar 12 00:00:00 EDT 2019},
month = {Tue Mar 12 00:00:00 EDT 2019}
}
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Works referenced in this record:
Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol
patent, September 2010
- Burk, Mark J.; Schilling, Christophe H.; Burgard, Anthony P.
- US Patent Document 7,803,589
Genetic modification of homolactic thermophilic bacilli
patent, July 2013
- Van Kranenburg, Richard; Van Hartskamp, Mariska; Heintz, Eelco Anthonius Johannes
- US Patent Document 8,497,128
Microorganisms and methods for conversion of syngas and other carbon sources to useful products
patent, June 2013
- Trawick, John D.; Burk, Mark J.; Burgard, Anthony P.
- US Patent Document 8,470,566
Method for the combined production of butanol and hydrogen
patent, April 2013
- Claassen, Pieternel A. M.; Budde, Miriam; De Vrije, Geertruida
- US Patent Document 8,420,358
Switchable photosystem-II designer algae for photobiological hydrogen production
patent, January 2010
- Lee, James Weifu
- US Patent Document 7,642,405
Hyperphotosynthetic organisms
patent, August 2010
- Devroe, Eric; Kosuri, Sriram; Berry, David Arthur
- US Patent Document 7,785,861
Microbiological Production of 3-Hydroxyisobutyric Acid
patent-application, March 2010
- Marx, Achim; Poetter, MArkus; Buchholz, Stefen
- US Patent Application 12/303161; 20100068773 A1
Synthesis of protein with an identification peptide
patent, October 1987
- Hopp, Thomas P.; Bektesh, Susan; Conlon, Paul J.
- US Patent Document 4,703,004
Hydrogen production with photosynthetic organisms and from biomass derived therefrom
patent-application, March 2005
- Berzin, Isaac
- US Patent Application 10/924742; 20050064577
Methods and compositions for the recombinant biosynthesis of n-alkanes
patent, September 2010
- Reppas, Nikos Basil; Ridley, Christian Perry
- US Patent Document 7,794,969
Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-HP)
patent-application, October 2011
- Lipscomb, Tanya E. W.; Lynch, Michael D.; Gill, Ryan T.
- US Patent Application 13/055138; 20110244575
Thermophile gene transfer
patent, February 1999
- Weber, J. Mark; Demirjian, David; Casadaban, Malcolm J.
- US Patent Document 5,872,238
Hyperphotosynthetic Organisms
patent-application, August 2009
- Devroe, Eric James; Kosuri, Sriram; Berry, David Arthur
- US Patent Application 12/268406; 20090203070
Gene knockout mesophilic and thermophilic organisms, and methods of use thereof
patent, May 2013
- Hogsett, David A.; Rajgarhia, Vineet
- US Patent Document 8,435,770
Synthesis of protein with an identification peptide, and hybrid polypeptide incorporating same
patent, November 1988
- Hopp, Thomas P.; Bektesh, Susan; Conlon, Paul J.
- US Patent Document 4,782,137
Sequestration of carbon dioxide with hydrogen to useful products
patent, March 2017
- Adams, Michael W. W.; Kelly, Robert M.; Hawkins, Aaron B.
- US Patent Document 9,587,256
Biological and Chemical Process Utilizing Chemoautotrophic Microorganisms for the Chemosythetic Fixation of Carbon Dioxide and or Other Inorganic Carbon Sources into Organic Compounds, and the Generation of Additional Useful Products
patent-application, May 2010
- Reed, John Stuart
- US Patent Application 12/613550; 20100120104
Compositions and methods for 3-hydroxypropionate bio-production from biomass
patent, November 2011
- Lynch, Michael D.
- US Patent Document 8,048,624
Process of purifying recombinant proteins and compounds useful in such process
patent, January 1997
- Sharma, Satish
- US Patent Document 5,594,115
Sporulation-deficient thermophilic microorganisms for the production of ethanol
patent, July 2013
- Atkinson, Anthony; Cripps, Roger; Eley, Kirstin
- US Patent Document 8,486,687
Energy production with hyperthermophilic organisms
patent, October 2012
- Remmereit, Jan; Thomm, Michael
- US Patent Document 8,278,087
Microorganisms and methods for carbon-efficient biosynthesis of MEK and 2-butanol
patent, April 2013
- Osterhout, Robin E.; Niu, Wei; Burgard, Anthony P.
- US Patent Document 8,420,375