Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1

Culiat, Cymbeline T.

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Title: Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1

Abstract

The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.

Inventors:: Culiat, Cymbeline T.

Issue Date:: Tue Mar 20 00:00:00 EDT 2018

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1429850

Patent Number(s):: 9920104

Application Number:: 14/495,942

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/70 - Carbohydrates
A61K35/28 - Bone marrow
A61K38/00 - Medicinal preparations containing peptides
A61K38/1709 - {from mammals}
A61K38/486 - {Elastase

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P17/00 - Drugs for dermatological disorders
A61P17/02 - for treating wounds, ulcers, burns, scars, keloids, or the like
A61P19/00 - Drugs for skeletal disorders
A61P21/00 - Drugs for disorders of the muscular or neuromuscular system
A61P21/04 - for myasthenia gravis
A61P3/10 - for hyperglycaemia, e.g. antidiabetics
A61P9/00 - Drugs for disorders of the cardiovascular system

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/47 - from mammals

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DOE Contract Number:: AC05-00OR22725

Resource Type:: Patent

Resource Relation:: Patent File Date: 2014 Sep 25

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

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                    Culiat, Cymbeline T. Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1.  United States: N. p., 2018. 
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                    Culiat, Cymbeline T. Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1.  United States.

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                    Culiat, Cymbeline T. Tue .  
        "Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1".  United States.  https://www.osti.gov/servlets/purl/1429850.

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@article{osti_1429850,

  title        = {Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1},

  author       = {Culiat, Cymbeline T.},

  abstractNote = {The present invention provides methods for promoting wound healing and treating muscle atrophy in a mammal in need. The method comprises administering to the mammal a Nell1 protein or a Nell1 nucleic acid molecule.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Mar 20 00:00:00 EDT 2018},

  month        = {Tue Mar 20 00:00:00 EDT 2018}

}

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Works referenced in this record:

Quantitative Comparison of Constitutive Promoters in Human ES cells
journal, August 2010

Norrman, Karin; Fischer, Yvonne; Bonnamy, Blandine
PLoS ONE, Vol. 5, Issue 8, Article No. e12413
https://doi.org/10.1371/journal.pone.0012413

Gene therapy for muscular dystrophy: current progress and future prospects
journal, June 2009

Trollet, Capucine; Athanasopoulos, Takis; Popplewell, Linda
Expert Opinion on Biological Therapy, Vol. 9, Issue 7, p. 849-866
https://doi.org/10.1517/14712590903029164

Coagulation dysregulation as a barrier to xenotransplantation in the primate
journal, June 2009

Lin, Chih Che; Cooper, David K. C.; Dorling, Anthony
Transplant Immunology, Vol. 21, Issue 2, p. 75-80
https://doi.org/10.1016/j.trim.2008.10.008

NELL-1 enhanced bone mineralization
patent-application, October 2006

Ting, Kang
US Patent Application 11/392294; 20060228392
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060228392

Expression system of NELL peptide
patent-application, June 2007

Ting, Kang; Kuroda, Shunichi; Wu, Ben
US Patent Application 11/601529; 20070128697
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070128697

Cell-Based Approaches for Cardiac Repair
journal, October 2006

Rubart, M.; Field, L. J.
Annals of the New York Academy of Sciences, Vol. 1080, Issue 1, p. 34-48
https://doi.org/10.1196/annals.1380.004

Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors
journal, January 2001

Maeda, Kenji; Matsuhashi, Sachiko; Tabuchi, Kazuo
Neurologia medico-chirurgica, Vol. 41, Issue 12, p. 582-589
https://doi.org/10.2176/nmc.41.582

Application ofex VivoGene Therapy in the Treatment of Parkinson's Disease
journal, March 1997

Raymon, H. K.; Thode, S.; Gage, F. H.
Experimental Neurology, Vol. 144, Issue 1, p. 82-91
https://doi.org/10.1006/exnr.1996.6392

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994

Ngo, J. Thomas; Marks, Joe; Karplus, Martin
The Protein Folding Problem and Tertiary Structure Prediction, p. 433-506
https://doi.org/10.1007/978-1-4684-6831-1_14

Adenovirus vectors encoding brain natriuretic peptide
patent-application, February 2006

Simari, Robert D.
US Patent Application 11/185327; 20060025367
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060025367

Effect of collagen matrices on dermal wound healing
journal, November 2003

Ruszczak, Z.
Advanced Drug Delivery Reviews, Vol. 55, Issue 12, p. 1595-1611
https://doi.org/10.1016/j.addr.2003.08.003

Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development
journal, May 2006

Zhang, Xinli; Cowan, Catherine M.; Jiang, Xinquan
Laboratory Investigation, Vol. 86, Issue 7, p. 633-644
https://doi.org/10.1038/labinvest.3700430

Nell peptide expression systems and bone formation activity of nell peptide
patent-application, December 2006

Ting, Kang; Kuroda, Shunichi; Wu, Ben
US Patent Application 10/544553; 20060292670
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060292670

Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2
journal, November 1999

Kuroda, Shun'ichi; Oyasu, Miho; Kawakami, Masakatsu
Biochemical and Biophysical Research Communications, Vol. 265, Issue 1, p. 79-86
https://doi.org/10.1006/bbrc.1999.1638

Method to Treat or Prevent a Skin Condition Using a Nell 1 Peptide
patent-application, September 2011

Mitchell, Dora P.; Culiat, Cymbeline T.; Lubit, Beverly W.
US Patent Application 13/011339; 20110236325
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110236325

From cardiac repair to cardiac regeneration – ready to translate?
journal, August 2006

Ott, Harald C.; Taylor, Doris A.
Expert Opinion on Biological Therapy, Vol. 6, Issue 9, p. 867-878
https://doi.org/10.1517/14712598.6.9.867

Ex vivo gene transfer and correction for cell-based therapies
journal, March 2011

Naldini, Luigi
Nature Reviews Genetics, Vol. 12, Issue 5, p. 301-315
https://doi.org/10.1038/nrg2985

In vitro and in vivo induction of bone formation based on ex vivo gene therapy using rat adipose-derived adult stem cells expressing BMP-7
journal, January 2005

Yang, M.; Ma, Q. J.; Dang, G. T.
Cytotherapy, Vol. 7, Issue 3, p. 273-281
https://doi.org/10.1080/14653240510027244

Current Concepts In Intervertebral Disk Restoration
journal, July 2000

Diwan, Ashish D.; Parvataneni, Hari K.; Khan, Safdar N.
Orthopedic Clinics of North America, Vol. 31, Issue 3, p. 453-464
https://doi.org/10.1016/S0030-5898(05)70163-2

Growth Factor Enhancement of Cardiac Regeneration
journal, January 2006

Rosenthal, Nadia; Santini, Maria Paola; Musarò, Antonio
Cell Transplantation, Vol. 15, Issue S1, p. 41-45
https://doi.org/10.3727/000000006783982287

Wound Healing--Aiming for Perfect Skin Regeneration
journal, April 1997

Martin, P.
Science, Vol. 276, Issue 5309, p. 75-81
https://doi.org/10.1126/science.276.5309.75

Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein–Protein Interaction with Protein Kinase C
journal, November 1999

Kuroda, Shun'ichi; Tanizawa, Katsuyuki
Biochemical and Biophysical Research Communications, Vol. 265, Issue 3, p. 752-757
https://doi.org/10.1006/bbrc.1999.1753

Composition for cartilage
patent-application, June 2007

Ting, Kang; Wu, Ben; Soo, Chia
US Patent Application 11/594510; 20070134291
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070134291

BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture
journal, December 2003

Schmitt, Bernhard; Ringe, Jochen; Häupl, Thomas
Differentiation, Vol. 71, Issue 9-10, p. 567-577
https://doi.org/10.1111/j.1432-0436.2003.07109003.x

Additivity of mutational effects in proteins
journal, September 1990

Wells, James A.
Biochemistry, Vol. 29, Issue 37, p. 8509-8517
https://doi.org/10.1021/bi00489a001

Skeletal muscle injury—molecular changes in the collagen during healing
journal, March 1985

Lehto, M.; Sims, T. J.; Bailey, A. J.
Research In Experimental Medicine, Vol. 185, Issue 2, p. 95-106
https://doi.org/10.1007/BF01854894

Nell-1 enhanced bone mineralization
patent-application, May 2006

Ting, Kang
US Patent Application 10/527786; 20060111313
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060111313

Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies
journal, May 2009

Hentze, Hannes; Soong, Poh Loong; Wang, Siew Tein
Stem Cell Research, Vol. 2, Issue 3, p. 198-210
https://doi.org/10.1016/j.scr.2009.02.002

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects
journal, March 2006

Desai, Jayashree; Shannon, Mark E.; Johnson, Mahlon D.
Human Molecular Genetics, Vol. 15, Issue 8, p. 1329-1341
https://doi.org/10.1093/hmg/ddl053

Regulation of bone morphogenetic proteins in early embryonic development
journal, October 2004

Yamamoto, Yukiyo; Oelgeschläger, Michael
Naturwissenschaften, Vol. 91, Issue 11, p. 519-534
https://doi.org/10.1007/s00114-004-0575-z

Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats
journal, December 1996

Watanabe, Takeshi K.; Katagiri, Toyomasa; Suzuki, Mikio
Genomics, Vol. 38, Issue 3, p. 273-276
https://doi.org/10.1006/geno.1996.0628

Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15
journal, January 2002

Rinchik, E. M.; Carpenter, D. A.; Johnson, D. K.
Proceedings of the National Academy of Sciences, Vol. 99, Issue 2, p. 844-849
https://doi.org/10.1073/pnas.022628199

The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals
journal, December 1998

Pettit, Dean K.; Gombotz, Wayne R.
Trends in Biotechnology, Vol. 16, Issue 8, p. 343-349
https://doi.org/10.1016/S0167-7799(98)01186-X

Cranial and vertebral defects associated with loss-of-function of Nell
patent-application, March 2006

Culiat, Cymbeline T.; Rinchik, Eugene M.
US Patent Application 11/192813; 20060053503
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060053503

Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts
journal, March 2007

Cowan, Catherine M.; Jiang, Xinquan; Hsu, Tiffany
Journal of Bone and Mineral Research, Vol. 22, Issue 6, p. 918-930
https://doi.org/10.1359/jbmr.070312

The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD)
journal, June 2004

Tsutsumi, Satoshi; Kamata, Nobuyuki; Vokes, Tamara J.
The American Journal of Human Genetics, Vol. 74, Issue 6, p. 1255-1261
https://doi.org/10.1086/421527

Bone marrow cells for cardiac regeneration and repair: current status and issues
journal, July 2006

Haider, Husnain Kh
Expert Review of Cardiovascular Therapy, Vol. 4, Issue 4, p. 557-568
https://doi.org/10.1586/14779072.4.4.557

The osteoinductive properties of Nell-1 in a rat spinal fusion model
journal, January 2007

Lu, Steven S.; Zhang, Xinli; Soo, Chia
The Spine Journal, Vol. 7, Issue 1, p. 50-60
https://doi.org/10.1016/j.spinee.2006.04.020

Biological and Biomaterial Approaches for Improved Islet Transplantation
journal, June 2006

Narang, Ajit S.; Mahato, Ram I.
Pharmacological Reviews, Vol. 58, Issue 2, p. 194-243
https://doi.org/10.1124/pr.58.2.6

Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
journal, August 2007

Franke, Andre; Hampe, Jochen; Rosenstiel, Philip
PLoS ONE, Vol. 2, Issue 8, Article No. e691
https://doi.org/10.1371/journal.pone.0000691

Effects of Administration Route on Migration and Distribution of Neural Progenitor Cells Transplanted into Rats with Focal Cerebral Ischemia, an MRI Study
journal, November 2009

Li, Lian; Jiang, Quan; Ding, Guangliang
Journal of Cerebral Blood Flow & Metabolism, Vol. 30, Issue 3, p. 653-662
https://doi.org/10.1038/jcbfm.2009.238

The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage
journal, April 1999

Luce, Milson J.; Burrows, Peter D.
Gene, Vol. 231, Issue 1-2, p. 121-126
https://doi.org/10.1016/S0378-1119(99)00093-1

Nell-1 induced bone formation within the distracted intermaxillary suture
journal, January 2006

Cowan, Catherine M.; Cheng, Samson; Ting, Kang
Bone, Vol. 38, Issue 1, p. 48-58
https://doi.org/10.1016/j.bone.2005.06.023

NELL-1 enhanced bone mineralization
patent, May 2006

Ting, Kang
US Patent Document 7,052,856
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7052856

A Study of the Role of Nell-1 Gene Modified Goat Bone Marrow Stromal Cells in Promoting New Bone Formation
journal, October 2007

Aghaloo, Tara; Jiang, Xinquan; Soo, Chia
Molecular Therapy, Vol. 15, Issue 10, p. 1872-1880
https://doi.org/10.1038/sj.mt.6300270

Clinical xenotransplantation: the next medical revolution?
journal, February 2012

Ekser, Burcin; Ezzelarab, Mohamed; Hara, Hidetaka
The Lancet, Vol. 379, Issue 9816, p. 672-683
https://doi.org/10.1016/S0140-6736(11)61091-X

Human NELL-1 Expressed in Unilateral Coronal Synostosis
journal, January 1999

Ting, Kang; Vastardis, Heleni; Mulliken, John B.
Journal of Bone and Mineral Research, Vol. 14, Issue 1, p. 80-89
https://doi.org/10.1359/jbmr.1999.14.1.80

Stem Cell Therapy in Perspective
journal, February 2003

Strauer, B. E.
Circulation, Vol. 107, Issue 7, p. 929-934
https://doi.org/10.1161/01.CIR.0000057525.13182.24

Cells as vehicles for therapeutic genes to treat liver diseases
journal, April 2008

Prieto, J.; Fernandez-Ruiz, V.; Kawa, M. P.
Gene Therapy, Vol. 15, Issue 10, p. 765-771
https://doi.org/10.1038/gt.2008.44

Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development
journal, December 2003

Zhang, Xinli; Carpenter, Dale; Bokui, Nobuyuki
Journal of Bone and Mineral Research, Vol. 18, Issue 12, p. 2126-2134
https://doi.org/10.1359/jbmr.2003.18.12.2126

Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1
patent-application, April 2009

Culiat, Cymbeline T.
US Patent Application 12/284667; 20090087415
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090087415

Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
journal, June 2001

Orlic, Donald; Kajstura, Jan; Chimenti, Stefano
Annals of the New York Academy of Sciences, Vol. 938, Issue 1, p. 221-230
https://doi.org/10.1111/j.1749-6632.2001.tb03592.x

A new function of Nell-1 protein in repressing adipogenic differentiation
journal, July 2011

James, Aaron W.; Pan, Angel; Chiang, Michael
Biochemical and Biophysical Research Communications, Vol. 411, Issue 1, p. 126-131
https://doi.org/10.1016/j.bbrc.2011.06.111

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
journal, January 2004

Lecker, Stewart H.; Jagoe, R. Thomas; Gilbert, Alexander
The FASEB Journal, Vol. 18, Issue 1, p. 39-51
https://doi.org/10.1096/fj.03-0610com

Nell-1-Induced Bone Regeneration in Calvarial Defects
journal, September 2006

Aghaloo, Tara; Cowan, Catherine M.; Chou, Yu-Fen
The American Journal of Pathology, Vol. 169, Issue 3, p. 903-915
https://doi.org/10.2353/ajpath.2006.051210

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Title: Methods for promoting wound healing and muscle regeneration with the cell signaling protein nell1

Abstract

Citation Formats

Quantitative Comparison of Constitutive Promoters in Human ES cells journal, August 2010

Gene therapy for muscular dystrophy: current progress and future prospects journal, June 2009

Coagulation dysregulation as a barrier to xenotransplantation in the primate journal, June 2009

NELL-1 enhanced bone mineralization patent-application, October 2006

Expression system of NELL peptide patent-application, June 2007

Cell-Based Approaches for Cardiac Repair journal, October 2006

Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors journal, January 2001

Application ofex VivoGene Therapy in the Treatment of Parkinson's Disease journal, March 1997

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox book, January 1994

Adenovirus vectors encoding brain natriuretic peptide patent-application, February 2006

Effect of collagen matrices on dermal wound healing journal, November 2003

Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development journal, May 2006

Nell peptide expression systems and bone formation activity of nell peptide patent-application, December 2006

Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2 journal, November 1999

Method to Treat or Prevent a Skin Condition Using a Nell 1 Peptide patent-application, September 2011

From cardiac repair to cardiac regeneration – ready to translate? journal, August 2006

Ex vivo gene transfer and correction for cell-based therapies journal, March 2011

In vitro and in vivo induction of bone formation based on ex vivo gene therapy using rat adipose-derived adult stem cells expressing BMP-7 journal, January 2005

Current Concepts In Intervertebral Disk Restoration journal, July 2000

Growth Factor Enhancement of Cardiac Regeneration journal, January 2006

Wound Healing--Aiming for Perfect Skin Regeneration journal, April 1997

Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein–Protein Interaction with Protein Kinase C journal, November 1999

Composition for cartilage patent-application, June 2007

BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture journal, December 2003

Additivity of mutational effects in proteins journal, September 1990

Skeletal muscle injury—molecular changes in the collagen during healing journal, March 1985

Nell-1 enhanced bone mineralization patent-application, May 2006

Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies journal, May 2009

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects journal, March 2006

Regulation of bone morphogenetic proteins in early embryonic development journal, October 2004

Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats journal, December 1996

Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15 journal, January 2002

The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals journal, December 1998

Cranial and vertebral defects associated with loss-of-function of Nell patent-application, March 2006

Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts journal, March 2007

The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD) journal, June 2004

Bone marrow cells for cardiac regeneration and repair: current status and issues journal, July 2006

The osteoinductive properties of Nell-1 in a rat spinal fusion model journal, January 2007

Biological and Biomaterial Approaches for Improved Islet Transplantation journal, June 2006

Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene journal, August 2007

Effects of Administration Route on Migration and Distribution of Neural Progenitor Cells Transplanted into Rats with Focal Cerebral Ischemia, an MRI Study journal, November 2009

The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage journal, April 1999

Nell-1 induced bone formation within the distracted intermaxillary suture journal, January 2006

NELL-1 enhanced bone mineralization patent, May 2006

A Study of the Role of Nell-1 Gene Modified Goat Bone Marrow Stromal Cells in Promoting New Bone Formation journal, October 2007

Clinical xenotransplantation: the next medical revolution? journal, February 2012

Human NELL-1 Expressed in Unilateral Coronal Synostosis journal, January 1999

Stem Cell Therapy in Perspective journal, February 2003

Cells as vehicles for therapeutic genes to treat liver diseases journal, April 2008

Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development journal, December 2003

Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1 patent-application, April 2009

Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice journal, June 2001

A new function of Nell-1 protein in repressing adipogenic differentiation journal, July 2011

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression journal, January 2004

Nell-1-Induced Bone Regeneration in Calvarial Defects journal, September 2006

Quantitative Comparison of Constitutive Promoters in Human ES cells
journal, August 2010

Gene therapy for muscular dystrophy: current progress and future prospects
journal, June 2009

Coagulation dysregulation as a barrier to xenotransplantation in the primate
journal, June 2009

NELL-1 enhanced bone mineralization
patent-application, October 2006

Expression system of NELL peptide
patent-application, June 2007

Cell-Based Approaches for Cardiac Repair
journal, October 2006

Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors
journal, January 2001

Application ofex VivoGene Therapy in the Treatment of Parkinson's Disease
journal, March 1997

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994

Adenovirus vectors encoding brain natriuretic peptide
patent-application, February 2006

Effect of collagen matrices on dermal wound healing
journal, November 2003

Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development
journal, May 2006

Nell peptide expression systems and bone formation activity of nell peptide
patent-application, December 2006

Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2
journal, November 1999

Method to Treat or Prevent a Skin Condition Using a Nell 1 Peptide
patent-application, September 2011

From cardiac repair to cardiac regeneration – ready to translate?
journal, August 2006

Ex vivo gene transfer and correction for cell-based therapies
journal, March 2011

In vitro and in vivo induction of bone formation based on ex vivo gene therapy using rat adipose-derived adult stem cells expressing BMP-7
journal, January 2005

Current Concepts In Intervertebral Disk Restoration
journal, July 2000

Growth Factor Enhancement of Cardiac Regeneration
journal, January 2006

Wound Healing--Aiming for Perfect Skin Regeneration
journal, April 1997

Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein–Protein Interaction with Protein Kinase C
journal, November 1999

Composition for cartilage
patent-application, June 2007

BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture
journal, December 2003

Additivity of mutational effects in proteins
journal, September 1990

Skeletal muscle injury—molecular changes in the collagen during healing
journal, March 1985

Nell-1 enhanced bone mineralization
patent-application, May 2006

Teratoma formation by human embryonic stem cells: Evaluation of essential parameters for future safety studies
journal, May 2009

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects
journal, March 2006

Regulation of bone morphogenetic proteins in early embryonic development
journal, October 2004

Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats
journal, December 1996

Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15
journal, January 2002

The development of site-specific drug-delivery systems for protein and peptide biopharmaceuticals
journal, December 1998

Cranial and vertebral defects associated with loss-of-function of Nell
patent-application, March 2006

Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts
journal, March 2007

The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD)
journal, June 2004

Bone marrow cells for cardiac regeneration and repair: current status and issues
journal, July 2006

The osteoinductive properties of Nell-1 in a rat spinal fusion model
journal, January 2007

Biological and Biomaterial Approaches for Improved Islet Transplantation
journal, June 2006

Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
journal, August 2007

Effects of Administration Route on Migration and Distribution of Neural Progenitor Cells Transplanted into Rats with Focal Cerebral Ischemia, an MRI Study
journal, November 2009

The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage
journal, April 1999

Nell-1 induced bone formation within the distracted intermaxillary suture
journal, January 2006

NELL-1 enhanced bone mineralization
patent, May 2006

A Study of the Role of Nell-1 Gene Modified Goat Bone Marrow Stromal Cells in Promoting New Bone Formation
journal, October 2007

Clinical xenotransplantation: the next medical revolution?
journal, February 2012

Human NELL-1 Expressed in Unilateral Coronal Synostosis
journal, January 1999

Stem Cell Therapy in Perspective
journal, February 2003

Cells as vehicles for therapeutic genes to treat liver diseases
journal, April 2008

Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development
journal, December 2003

Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1
patent-application, April 2009

Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
journal, June 2001

A new function of Nell-1 protein in repressing adipogenic differentiation
journal, July 2011

Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
journal, January 2004

Nell-1-Induced Bone Regeneration in Calvarial Defects
journal, September 2006