Site-specific incorporation of redox active amino acids into proteins
Abstract
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.
- Inventors:
- Issue Date:
- Research Org.:
- The Scripps Research Inst., La Jolla, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1398985
- Patent Number(s):
- 9783798
- Application Number:
- 13/344,436
- Assignee:
- The Scripps Research Institute
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
- DOE Contract Number:
- FG03-00ER45812
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 Jan 05
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Alfonta, Lital, Schultz, Peter G., and Zhang, Zhiwen. Site-specific incorporation of redox active amino acids into proteins. United States: N. p., 2017.
Web.
Alfonta, Lital, Schultz, Peter G., & Zhang, Zhiwen. Site-specific incorporation of redox active amino acids into proteins. United States.
Alfonta, Lital, Schultz, Peter G., and Zhang, Zhiwen. Tue .
"Site-specific incorporation of redox active amino acids into proteins". United States. https://www.osti.gov/servlets/purl/1398985.
@article{osti_1398985,
title = {Site-specific incorporation of redox active amino acids into proteins},
author = {Alfonta, Lital and Schultz, Peter G. and Zhang, Zhiwen},
abstractNote = {Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Oct 10 00:00:00 EDT 2017},
month = {Tue Oct 10 00:00:00 EDT 2017}
}
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