Positive modulator of bone morphogenic protein-2
Abstract
Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1361549
- Patent Number(s):
- 9670258
- Application Number:
- 15/240,977
- Assignee:
- Brookhaven Science Associates, LLC
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
- DOE Contract Number:
- ACO2-98CH1086
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2016 Aug 18
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Zamora, Paul O., Pena, Louis A., Lin, Xinhua, and Kazuyuki, Takahashi. Positive modulator of bone morphogenic protein-2. United States: N. p., 2017.
Web.
Zamora, Paul O., Pena, Louis A., Lin, Xinhua, & Kazuyuki, Takahashi. Positive modulator of bone morphogenic protein-2. United States.
Zamora, Paul O., Pena, Louis A., Lin, Xinhua, and Kazuyuki, Takahashi. Tue .
"Positive modulator of bone morphogenic protein-2". United States. https://www.osti.gov/servlets/purl/1361549.
@article{osti_1361549,
title = {Positive modulator of bone morphogenic protein-2},
author = {Zamora, Paul O. and Pena, Louis A. and Lin, Xinhua and Kazuyuki, Takahashi},
abstractNote = {Compounds of the present invention of formula I and formula II are disclosed in the specification and wherein the compounds are modulators of Bone Morphogenic Protein activity. Compounds are synthetic peptides having a non-growth factor heparin binding region, a linker, and sequences that bind specifically to a receptor for Bone Morphogenic Protein. Uses of compounds of the present invention in the treatment of bone lesions, degenerative joint disease and to enhance bone formation are disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jun 06 00:00:00 EDT 2017},
month = {Tue Jun 06 00:00:00 EDT 2017}
}
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